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Zebrafish larvae lacking beta1AR (Montrer ADRB1 Protéines) expression by morpholino knockdown displayed lower heart rates than control fish, whereas larvae deficient in both beta2aAR and beta2bAR expression exhibited significantly higher heart rates than controls.
Here, the mechanism by which norepinephrine (NE)regulates prostate cancer DTCs in the marrow is explored. NE directly stimulated prostate cancer cell proliferation through beta2-adrenergic receptors (ADRB2).. NE also altered prostate cancer proliferation in the marrow niche by indirectly downregulating the secretion of the dormancy inducing molecule growth arrest specific-6 (GAS6 (Montrer GAS6 Protéines)) expressed by osteoblasts.
Adrenergic Receptor beta-2 signaling in the airway epithelium promotes eosinophilic inflammation, mucous metaplasia, and airway contractility.
the present study demonstrated that cardiac contractility/relaxation and heart rate is increased in beta1AR (Montrer ADRB1 Protéines) TG and beta2AR TG mice, and indicated that this increase may be related to the overexpression of G proteins and Gproteinassociated proteins.
S1928A KI mice failed to induce long-term potentiation in response to prolonged theta-tetanus (PTT-LTP (Montrer SCP2 Protéines)), a form of synaptic plasticity that requires Cav1.2 (Montrer CACNA1C Protéines) and enhancement of its activity by the beta2-adrenergic receptor (beta2AR)-cAMP-PKA cascade.
activation of beta2AR decreased cerebral amyloid plaques through the up-regulation of alpha-secretase activity and by decreasing the phosphorylation of APP (Montrer APP Protéines) at Thr668
Together, these data indicate that high-fat diet promotes phosphorylation of the beta2 AR, contributing to impairment of cardiac contractile reserve before cardiac structural and functional remodelling, suggesting that early intervention in the insulin (Montrer INS Protéines)-adrenergic signalling network might be effective in prevention of cardiac complications in diabetes
beta2-AR deletion is associated to selective hepatic insulin (Montrer INS Protéines) resistance and preserved skeletal muscle insulin (Montrer INS Protéines) sensitivity.
The diurnal variation of the humoral immune response was dependent on beta2AR-mediated neural signals and was diminished when lymphocyte recirculation through lymph nodes was stopped.
knocking out of the beta1/2 (Montrer TFAP2B Protéines) receptor significantly diminished the ST25 acupuncture-induced inhibition of gastric motility and jejunal motility without significantly altering the enhancement of colonic motility induced by acupuncture at ST25.
The authors show that phosphorylation of S1928 displaces the beta-2 adrenergic receptor from Cav1.2 (Montrer CACNA1C Protéines) upon beta-adrenergic stimulation rendering Cav1.2 (Montrer CACNA1C Protéines) refractory for several minutes from further beta-adrenergic stimulation.
These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor (Montrer NR3C1 Protéines) with neonatal glucose and lipid metabolism.
ADRb2 shows lipid scrambling activity.
relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R (Montrer OXTR Protéines)) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle
This study provided proof that SNPs within ADRB2 is significantly associated with the susceptibility to and the prognosis of cervical vertigo, so that NPY (Montrer NPY Protéines) and NA might serve as the precise diagnostic marker and treatment target of cervical vertigo.
A functional SNP (rs12654778), upstream of ADRB2, was significantly associated with increased risk for COPD (Montrer ARCN1 Protéines).
Data indicate clustering of beta-2 adrenergic receptor (beta2AR) variants based on their signaling profiles.
We found that polymorphic Arg16Gly in the ADRB2 gene and Ala54Thr in the FABP2 (Montrer FABP2 Protéines) gene had a discernible effect on the renal function in Chinese type 2 DN. Our data further revealed that homozygous Gly16 allele and Thr54 allele concomitantly conferred a significantly higher risk in the eGFR (Montrer EGFR Protéines) reduction.
decreased beta2AR functionality in patients with OA and LC was independent of patient's beta2AR genotype.
Phosphorylation of the C-terminal region of ADRB2 allosterically alters the conformation around M215(5.54) and M279(6.41), located on transemembrane helices 5 and 6.
Downregulation of the expression of DUSP1 or protein phosphatase 1 led to a decline in the beta2adrenergic receptormediated dephosphorylation of ERK1/2.
In vitro studies confirmed that activation of b2AR can promote epithelial mesenchymal transition in Tongue squamous cell carcinoma (TSCC) by initiating an interleukin6/Stat3 (Montrer STAT3 Protéines)/Snail1 (Montrer SNAI1 Protéines) pathway. These results suggest that b2AR has an oncogenic role in TSCC and may be a potential therapeutic target in TSCC.
Study analyzed dynamic behavior of 16 important residues in the binding pockets of beta2-adrenergic receptor bound with a variety of ligands, among which D1133.32 and N3127.39 are essential for ligand binding. The polar interactions with residues in TM5, particularly S2035.42 and S2075.46, are related to the agonistic properties, whereas hydrophobic interactions with residues in TM5 and TM6 help stabilize the receptor.
SNPs at codon 16 of the ADRB2 plays a role in the oxidative metabolic demand during exercise.
The Galphas (Montrer GNAS Protéines) and Galphaq (Montrer GNAQ Protéines) peptides adopt different orientations in beta2-AR and V1AR (Montrer AVPR1A Protéines), respectively. The beta2-AR/Galphas (Montrer GNAS Protéines) peptide interface is dominated by electrostatic interactions, whereas the V1AR (Montrer AVPR1A Protéines)/Galphaq (Montrer GNAQ Protéines) peptide interactions are predominantly hydrophobic.
A persistent B2R (Montrer BDKRB2 Protéines)-beta2AR heterodimer was confirmed in bradykinin-stimulated and non-stimulated left ventricular myocardium. BK transactivation of beta2AR enhanced beta2AR-mediated release of tPA (Montrer PLAT Protéines).
Prolactin (Montrer PRL Protéines) infusion brought about the inhibition of a vasodilatory beta(2)-adrenergic receptor-mediated effect related to the NO intracellular pathway
Intracoronary intermedin (Montrer ADM2 Protéines) 1-47 augments cardiac perfusion and function in anesthetized pigs: role of calcitonin (Montrer CALCA Protéines) receptors and beta-adrenoreceptor-mediated nitric oxide release.
The results imply ADRB-2-mediated actions in the development of primate follicles
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes.
adrenergic receptor beta-2
, adrenergic, beta-2-, receptor, surface
, beta-2 adrenergic receptor
, beta-2b-adrenergic receptor
, beta-2 adrenoceptor
, beta-2 adrenoreceptor
, beta 2-AR
, adrenergic receptor beta 2
, adrenergic, beta-2, receptor, surface
, catecholamine receptor
, beta2-adrenergic receptor
, Adrenergic beta 2- receptor surface
, adrenergic receptor, beta 2
, Beta-2 adrenergic receptor
, Beta-2 adrenoceptor
, Beta-2 adrenoreceptor
, beta 2 adrenergic receptor
, beta-2-adrenergic receptor