Profil protéine

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with GRM2

• glutamate metabotropic receptor 2 (GRM2) anticorps
• glutamate receptor, metabotropic 2 (Grm2) anticorps
• glutamate metabotropic receptor 2 (Grm2) anticorps

• 4930441L02Rik anticorps
• GLUR2 anticorps
• Gprc1b anticorps
• mGlu2 anticorps
• mGluR2 anticorps
• Afficher tous les alias de synonymes
• mGluR7 anticorps

Protein level used designations for GRM2

glutamate metabotropic receptor 2 , glutamate receptor homolog , metabotropic glutamate receptor 2 , G protein coupled receptor, family C, group 1, member B , G protein-coupled receptor, family C, group 1, member B , mGluR2