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Human Polyclonal MC1 Receptor Primary Antibody pour IF (p), IHC (p) - ABIN686287
Schmitz, Botte, Sotto, Borba, Bonfa, de Mello: Increased corticotropin-releasing hormone (CRH) expression in cutaneous lupus lesions. dans Lupus 2015
R151C MC1R is associated with an increased risk of melanoma in a Russian population of Eastern Siberia.
Melanocortin 1 receptor polymorphisms is associated with increased melanoma risk.
This review briefly discusses the role of paracrine factors, focusing on alpha-melanocortin (alpha-melanocyte stimulating hormone; alpha-MSH), in regulating melanogenesis and the response of melanocytes to UV, and describes a chemoprevention strategy based on targeting the melanocortin 1 receptor (MC1R) by analogs of its physiological agonist alpha-MSH. [review]
the association between particular MC1R alleles and the risk of skin cancers, was investigated.
there is an association between TERT promoter mutations and MC1R variants in melanoma patients
with regard to cutaneous malignant melanoma risk, no association found in the combination of GSTP1 Ile105Val with MC1R RHC-variant alleles [meta-analysis]
In familial melanoma patients, the presence of MC1R R variants was associated with an increased prevalence of environmental risk factors and features associated with UV radiation-induced damage.
In melanomas and for somatic C>T mutations, a signature linked to sun exposure, the expected single-nucleotide variant count associated with the presence of an R allele is estimated to be 42% (95% CI, 15-76%) higher than that among persons without an R allele.
These data clearly show a new and hitherto unsuspected role for MC1R in noncutaneous solid tissues before birth.
In both melanoma cell lines, alphaMSH determined the reduction of proliferation through the PI(4,5)P2/PLC pathway, employing PPARgamma as an effector element. These evidence could offer perspectives for new therapeutic approaches for melanoma.
Carriage of any MC1R variant, one variant and two or more variants, compared with not having such variants was significantly associated with fair hair color, skin type I/II, and presence of freckles.
key molecular events driving MC1R-mediated enhancement of genome maintenance and MC1R-induced pigment induction in melanocytes are distinct
amino acid residue 128 in Transmembrane 3 (TM3) of MC1R, or amino acid residue L133 in TM3 of the MC4R, play crucial roles in ligand des-Trp(9)-NDP-alpha-MSH selectivity at MC1R or MC4R.
In a heterologous expression system, MC1R-dependent Arrestins B ubiquitination was enhanced by overexpression of MGRN1 and was impaired by siRNA-mediated MGRN1 knockdown thus pointing to MGRN1 as the responsible E3-ligase.
POMC and MC1R were significantly lower in vitiligo lesional skin than in non-lesional skin as well as in controls and they were significantly higher in non-lesional skin than in the skin of the controls.
MC1R gene could modify the age of onset in Spanish Huntington's disease patients.
results highlight a central role for MC1R palmitoylation in pigmentation and protection against melanoma
MC1R variant p.V92M (rs2228479) was present in 72 (14%) patients and 15 (9%) controls and confers increased risk of developing late-onset Alzheimer's disease, especially in those patients whose genetic risk could not be explained by APOE genotype. This association remains and even increased in the subset of 69 patients with typical AD cerebrospinal fluid profile. No association was found between p.V92M and age of onset.
MC1RR163Q is associated with a lower risk of complicated sepsis after trauma. Therapeutic targeting of MC1R may be beneficial for trauma patients at risk for complicated sepsis
This study evaluated the association of perceived facial age with multiple single nucleotide polymorphisms in the MC1R gene.
Deficiency in MC1-R signaling exacerbates atherosclerosis by disturbing cholesterol handling and by increasing arterial monocyte accumulation.
Collectively, our findings suggest that melanocortin therapy confers a proteinuria reducing and podoprotective effect in proteinuric glomerulopathies via MC1R-independent mechanisms.
We conclude that MC1R plays an important role in regulating melanoma growth and morphology
Activation of Mc1r prevents cholesterol uptake and confers protection against macrophage foam cell formation.
MC1-mediated effects were reduced, and MC3 anti-inflammatory circuits predominated. Mice bearing a nonfunctional MC1 displayed a transient exacerbation of neutrophil recruitment after global I/R, which diminished by 2 hours.
MR importantly contributes to diabetes-associated vascular dysfunction by inducing oxidative stress and by increasing the activity of redox-sensitive proteins
MC1 has an endogenous regulatory function in collagen synthesis and controls the extent of fibrotic stress responses of the skin.
A melanin-independent interaction between Mc1r and Met signaling pathways is required for hepatocyte growth factor-dependent melanoma.
In summary, we have identified a new alpha-MSH-MC1R physiologic pathway that reduces HO-induced RPE cell damage, and might minimize the risk of developing AMD.
Absence of Mc1r does not impair the inflammatory response to UV radiation or the generation of immunosuppression.
MC1R decrease the inflammation in vitro and vivo, and might be part of a signaling pathway in inflammatory diseases.
Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice.
MC1R regulates melanoma cell migration via inhibition of syndecan-2 expression.
Spatiotemporal localization of MC1R and alpha-MSH in cutaneous wounds warrants future investigation into the role of MC1R/alpha-MSH signaling in the inflammatory and fibroproliferative responses to cutaneous injury.
Data show RNA interference that targets Ube3a in P19 cells caused downregulation of Mc1r and Nr4a2, whereas overexpression of Ube3a results in the upregulation of Mc1r and Nr4a2.
MC1R contributes to pain of inflammatory origin.
MC1R protects by a combination of pigmentary and non-pigmentary effects in vivo and when MC1R function is compromised the melanin type in skin is still protective against UVR
The pigmentation of atopic dermatitis is related to increased levels of alpha-MSH, MC1R (in the skin) and MC3R (in intestines).
Evolution of mc1r in zebrafish is reported.
This study demonstrated a direct role for mc1r in zebrafish melanosome dispersal in response to background, and used chemical modification of this pathway to uncover a possible new layer of regulation in melanosome dispersal in zebrafish.
Considering that mRNA for MC2R and the MC1R variants are present in head kidney cells, the authors hypothesized that MC2R activity is modulated in part by different binding affinities of the MC1R variants for MRAP.
variation in MC1R, ASIP, and MATP genes in horse coat color
no significant relationship with behavior at the MC1R locus
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
, melanocyte-stimulating hormone receptor
, melanotropin receptor
, extension recessive yellow
, melanocortin receptor 1
, melanocortin-1 receptor
, tobacco darkening
, melanocortin 1 receptor
, Melanotropin receptor
, Melanocortin receptor 1
, Melanocyte-stimulating hormone receptor
, alpha melanocyte stimulating hormone receptor
, tubulin, beta 3 class III