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Mutations in residues S4/S5 and S17/E18 retained MC5R at the ER/Golgi complex and did not affect MC5R homodimerization.
melanocortin receptors MC2R, MC3R and MC5R are most abundantly expressed in glandular epithelium of the endometrium
MC2R and MC1R signals are consecutively required for the regulation of EPO signal transduction in erythroblast differentiation, and MC5R signal transduction is required to induce enucleation.
D115 and D119 in TM3, F195 in TM5, and F254 in TM6 may form a binding pocket for NDP-alpha-MSH binding.
Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and beta-arrestins 1/2.
Data suggest that antagonists of MC1R and MC5R could be effective inhibitors of sebaceous gland differentiation and the production of sebum-specific lipids.
Outlining the ligand recognition sites in the melanocortin receptors.
Variations in the melanocortin 5 receptor gene are unlikely to confer susceptibility to bipolar disorder in this sample.
Further structure-activity studies of lactam derivatives of MT-II and SHU-9119 were made at MC5R.
MC5R signals through a PI3K-regulated Akt-independent pathway leading to downstream activation of ERK1/2
importance for MC5r and A2Ar expression in EAU to promote the induction of protective regulatory immunity, and the expression of MC5r and A2Ar on human immune cells, suggests that it may be possible to utilize the melanocortin-adenosinergic pathways to induce protective immunity in uveitic patients
MC5r-dependent regulatory immunity increased CD11b(+)F4/80(+)Ly-6C(low)Ly-6G(+)CD39(+)CD73(+) APCs in the spleen of post-experimental autoimmune uveoretinitis mice.
In 3T3-L1 adipocytes, alpha-MSH-activated MC5-R signals through the cAMP/PKA and MAPK/ERK1/2 pathways.
Melanocortin receptors 1 and 5 might mediate inhibitory effects of alpha-melanocyte-stimulating hormone on antigen-induced chronic allergic skin inflammation in IgE transgenic mice.
Dependence on MC5r expression promotes or selectively activates IRBP-specific FoxP3+ TGF-beta+ CD25+CD4+ Treg cells in the spleens of experimental uveitis-recovered mice.
melanocortin 2 receptor and melanocortin 5 receptor are lipolytic mediators in differentiated 3T3-L1 adipocytes
Data show that melanocortins regulate Il6 gene expression and production in 3T3-L1 adipocytes through melanocortin receptors 2 and 5.
causes excretion of urinary pheromones that delay aggressive responses by other males
The results establish that MRAP forms stable complexes with two different melanocortin receptors, facilitating surface expression of MC2 receptor but disrupting dimerization and surface localization of MC5 receptor.
This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation.
melanocortin receptor 5
, melanocortin-5 receptor
, melanocortin 5-receptor
, G-protein-coupled receptor
, melanocortin 5 receptor
, melanocortin 1 receptor Mc1r
, melanocortin 5b receptor