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prostacyclin regulates bone growth via the Epac/Rap1 pathway
cAMP binds Xepac protein enabling it to activate the Ca2 (Montrer CA2 Anticorps)+ pathway, which is necessary to start and maintain X. laevis vitellogenin (Montrer VTG Anticorps) uptake.
Data show that the Epac-Rap1 signaling axis is involved in triapine resistance.
This study indicates a novel role for Epac1 in PGE2-induced epithelial-to-mesenchymal transition and subsequent activation of beta-catenin (Montrer CTNNB1 Anticorps)
EPAC1 and EPAC2 (Montrer RAPGEF4 Anticorps) expression levels were significantly lower in bladder cancer tissue than in normal bladder tissue. In addition, bladder cancer cell lines showed reduced EPAC1 mRNA expression. Furthermore, EPAC1 overexpression in bladder cancer cell lines induced morphologic changes and markedly suppressed cell migration without affecting cell viability.
study suggests for the first time the mechanistic insights of mode of action of a primary cAMP-dependent sensor, Exchange protein activated by cAMP 1 (EPAC1), via its interaction with A-kinase anchoring protein (Montrer AKAP13 Anticorps) 9 (AKAP9 (Montrer AKAP9 Anticorps)).
We show that hematopoietic cell generation requires cAMP signaling through the Exchange proteins activated by cAMP (cAMP-Epac) axis..in hematopoietic progenitor and stem-like cells, cAMP induction mitigated oxidative stress, created a redox-state balance, and enhanced C-X-C chemokine receptor type 4 (CXCR4 (Montrer CXCR4 Anticorps)) expression, benefiting the maintenance of these primitive cells
No significant association was observed between RAPGEF3 SNPs and the risk of Alzheimer's disease or neuropsychiatric inventory scores.
This review focus is on the function of Epac in the heart. Accumulating evidence has revealed that both Epac1 and Epac2 (Montrer RAPGEF4 Anticorps) play important roles in the structure and function of the heart under physiological and pathological conditions. [review]
This interaction is promoted by EPAC1 activation, triggering its translocation to the plasma membrane and binding to NHERF1 (Montrer SLC9A3R1 Anticorps). Our findings identify a new CFTR (Montrer CFTR Anticorps)-interacting protein and demonstrate that cAMP activates CFTR (Montrer CFTR Anticorps) through two different but complementary pathways - the well-known PKA-dependent channel gating pathway and a new mechanism regulating endocytosis that involves EPAC1.
The contribution of EGFR (Montrer EGFR Anticorps), EPAC, and Ca(2 (Montrer CA2 Anticorps)+) in CDCA-induced activation of CFTR (Montrer CFTR Anticorps)-dependent Cl(-) secretion.
Microtubule stabilization was further suggested by the finding that ascorbate increased the amount of Epac1 bound to alpha-tubulin (Montrer TUBA4A Anticorps).
studies indicate that Epac1 plays important roles in promoting VSMC proliferation and phenotypic switch in response to vascular injury, therefore, representing a therapeutic target for vascular proliferative diseases.
These data indicate that Epac1 may be protective to the retina through inhibition of key inflammatory mediators.
Arrhythmic effects of Epac-mediated ryanodine receptor (Montrer RYR3 Anticorps) activation in Langendorff-perfused murine hearts
In retinopathy, EPAC-1 expression is decreased in a microRNA-7-mediated manner, contributing to endothelial dysfunction.
Epac1 exerts a tonic inhibition of in vivo basal microvascular permeability
In behavioral tests, Epac1-/- mice exhibited similar phenotype to those of WT mice.
2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 (Montrer CNR1 Anticorps) receptors. Among the six isoforms of phospholipase C (PLC (Montrer PLC Anticorps); PLCbeta, PLCgamma, PLCdelta, PLCepsilon (Montrer PLCE1 Anticorps), PLCzeta (Montrer PLCz1 Anticorps), PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT (Montrer DHDDS Anticorps)-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress...
Data suggest that Epac1 reduces formation of the NLRP3 (Montrer NLRP3 Anticorps) inflammasome to reduce inflammatory responses in the retinal vasculature.
Results demonstrate that Epac1 plays an important role in regulating energy balance and glucose homeostasis by promoting leptin (Montrer LEP Anticorps) expression and secretion in white adipose tissue.
data demonstrate that endogenous PGE2, EP2 (Montrer SPAG11A Anticorps) receptors, and EPAC are prerequisites for maximal LPS (Montrer TLR4 Anticorps)-induced IL-33 (Montrer IL33 Anticorps) expression and that exogenous PGE2 can amplify IL-33 (Montrer IL33 Anticorps) production via EP2 (Montrer SPAG11A Anticorps) and EP4 (Montrer PTGER4 Anticorps) receptors.
binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner
Rap guanine nucleotide exchange factor (GEF) 3
, RAP guanine-nucleotide-exchange factor 3
, exchange protein directly activated by cAMP 1
, rap guanine nucleotide exchange factor 3
, Rap1 guanine-nucleotide exchange factor
, rap guanine nucleotide exchange factor 3-like
, EPAC 1
, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
, cAMP-regulated guanine nucleotide exchange factor I
, exchange factor directly activated by cAMP 1
, cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI)
, epac 1