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prostacyclin regulates bone growth via the Epac/Rap1 pathway
cAMP binds Xepac protein enabling it to activate the Ca2 (Montrer CA2 Anticorps)+ pathway, which is necessary to start and maintain X. laevis vitellogenin (Montrer VTG Anticorps) uptake.
Cyclic AMP (Montrer APRT Anticorps) (cAMP), a secondary messenger responsible for various physiological processes regulates cell metabolism by activating Protein kinase A (PKA) and by targeting exchange protein directly activated by cAMP (EPAC). EPAC is present in two isoforms EPAC1 and EPAC2 (Montrer RAPGEF4 Anticorps), which exhibit different tissue distribution and is involved in GDP/GTP (Montrer AK3 Anticorps) exchange along with activating Rap1 (Montrer RABGEF1 Anticorps)- and Rap2 (Montrer RAP2A Anticorps)-mediated signaling pathways.
These data reveal a MAPK pathway-independent switch in response to cAMP signaling during melanoma progression.Implications: The prosurvival mechanism involving the cAMP-EPAC-RAP1 signaling pathway suggest the potential for new targeted therapies in melanoma.
Authors show that blockade of cAMP signaling using MDL12330A led to an increase in PUMA (Montrer BBC3 Anticorps) transcript levels, but not p21 (Montrer CDKN1A Anticorps) in melanoma cells. Results suggest that transcriptional repression is one of the functions of the cAMP-Epac signaling pathway.
Results show that Epac1 binds to importin beta1 which prevents its accumulation in plasma membrane and, uncover a cAMP-independent function of Epac1 at the plasma membrane in the regulation of neurite outgrowth.
Data show that the Epac-Rap1 signaling axis is involved in triapine resistance.
This study indicates a novel role for Epac1 in PGE2-induced epithelial-to-mesenchymal transition and subsequent activation of beta-catenin (Montrer CTNNB1 Anticorps)
EPAC1 and EPAC2 (Montrer RAPGEF4 Anticorps) expression levels were significantly lower in bladder cancer tissue than in normal bladder tissue. In addition, bladder cancer cell lines showed reduced EPAC1 mRNA expression. Furthermore, EPAC1 overexpression in bladder cancer cell lines induced morphologic changes and markedly suppressed cell migration without affecting cell viability.
study suggests for the first time the mechanistic insights of mode of action of a primary cAMP-dependent sensor, Exchange protein activated by cAMP 1 (EPAC1), via its interaction with A-kinase anchoring protein (Montrer AKAP13 Anticorps) 9 (AKAP9 (Montrer AKAP9 Anticorps)).
We show that hematopoietic cell generation requires cAMP signaling through the Exchange proteins activated by cAMP (cAMP-Epac) axis..in hematopoietic progenitor and stem-like cells, cAMP induction mitigated oxidative stress, created a redox-state balance, and enhanced C-X-C chemokine receptor type 4 (CXCR4 (Montrer CXCR4 Anticorps)) expression, benefiting the maintenance of these primitive cells
No significant association was observed between RAPGEF3 SNPs and the risk of Alzheimer's disease or neuropsychiatric inventory scores.
Epac activation reduces inflammation and microvascular permeability in an acute lung injury model.
studies indicate that Epac1 plays important roles in promoting VSMC proliferation and phenotypic switch in response to vascular injury, therefore, representing a therapeutic target for vascular proliferative diseases.
These data indicate that Epac1 may be protective to the retina through inhibition of key inflammatory mediators.
Arrhythmic effects of Epac-mediated ryanodine receptor (Montrer RYR3 Anticorps) activation in Langendorff-perfused murine hearts
In retinopathy, EPAC-1 expression is decreased in a microRNA-7-mediated manner, contributing to endothelial dysfunction.
Epac1 exerts a tonic inhibition of in vivo basal microvascular permeability
In behavioral tests, Epac1-/- mice exhibited similar phenotype to those of WT mice.
2-arachidonoylglycerol (2-AG) is an endogenous cannabinoid that depresses synaptic transmission through stimulation of CB1 (Montrer CNR1 Anticorps) receptors. Among the six isoforms of phospholipase C (PLC (Montrer PLC Anticorps); PLCbeta, PLCgamma, PLCdelta, PLCepsilon (Montrer PLCE1 Anticorps), PLCzeta (Montrer PLCz1 Anticorps), PLCeta), only PLCbeta has been linked to 2-AG synthesis. Here we demonstrate that 8-CPT (Montrer DHDDS Anticorps)-2Me-cAMP, a selective agonist of the cAMP sensor protein Epac, enhances 2-AG-mediated synaptic depress...
Data suggest that Epac1 reduces formation of the NLRP3 (Montrer NLRP3 Anticorps) inflammasome to reduce inflammatory responses in the retinal vasculature.
Results demonstrate that Epac1 plays an important role in regulating energy balance and glucose homeostasis by promoting leptin (Montrer LEP Anticorps) expression and secretion in white adipose tissue.
binds cAMP and activates the Ras superfamily guanine nucleotide binding protein (Rap1A)in a PKA-independent manner
Rap guanine nucleotide exchange factor (GEF) 3
, RAP guanine-nucleotide-exchange factor 3
, exchange protein directly activated by cAMP 1
, rap guanine nucleotide exchange factor 3
, Rap1 guanine-nucleotide exchange factor
, rap guanine nucleotide exchange factor 3-like
, EPAC 1
, Rap1 guanine-nucleotide-exchange factor directly activated by cAMP
, cAMP-regulated guanine nucleotide exchange factor I
, exchange factor directly activated by cAMP 1
, cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI)
, epac 1