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Pig (Porcine) Polyclonal CIITA Primary Antibody pour WB - ABIN97339
Koues, Dudley, Mehta, Greer: The 19S proteasome positively regulates histone methylation at cytokine inducible genes. dans Biochimica et biophysica acta 2009
Show all 2 Pubmed References
Human Polyclonal CIITA Primary Antibody pour IHC (p), WB - ABIN4886541
Sun, Huang, Yu, Zhang, Xu, Zhang, Li, Dong, Guo, Wang: Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation. dans Cell death & disease 2016
Low CIITA expression is associated with cancer.
This study provided evidence that CIITA is required for alpha-syn-induced MHCII expression and subsequent infiltration of peripheral immune cells in to the midbrain.
study found that CIITA exerts a highly restricted control over only the MHCII, H2-DO and H2-DM genes, in DC1 and DC2 cDC subsets, but not over other proposed targets
Decreasing CIITA expression in allogeneic MSCs abolished MHC II induction during myogenic differentiation and prevented immunorejection of these cells from the infarcted myocardium, which enhanced beneficial functional effects of MSC implantation on myocardial repair.
this study shows that genetic polymorphisms in the type I promoter of C2ta regulate MHC-II expression and T-cell responses but do not necessarily have a strong impact on autoimmune diseases
CIITA interacted with and recruited PRMT5 to the MHC II promoter and mediated the synergy between PRMT5 and ASH2/WDR5 to activate MHC II transcription
NLRC5 and CIITA thus emerge as paradigms for a novel class of transcriptional regulators dedicated for transactivating extremely few, phylogenetically related genes.
Data suggest that class II transactivator CIITA expression is likely mediated in hematopoietic cells by common elements with promoter accessibility having a part in promoter choice.
Transfection of CIITA in poorly immunogenic PDA cells resulted in increased expression levels of the MHC class II molecule. CIITA-tumor cells were rejected in 80% to 100% of injected mice.
IFN-gamma exerts a critical anti-inflammatory function in the intestine which protects against colitis by inducing MHCII expression on intestinal epithelial cells.
tumor cell lines with a defective expression of CIITA transcripts lack MHC class II expression
study provides compelling genetic evidence that CIITA, the molecular switch of antigen presentation, plays a novel, unexpected function in skeletal homeostasis, independent of MHC Class II expression and T cells
Data indicate that during Mycobacterium bovis BCG infection, iNOS/NO responsive KLF4 induces EZH2 and miR-150 functions to regulate CIITA expression.
CIITA isoform I is dispensable for proper T-cell development.
Mutated major histocompatibility complex class II transactivator up-regulates interleukin-33-dependent differentiation of Th2 subset through Nod2 binding for NLR (NOD-like receptor) signaling initiation.
Mice lacking conventional class Ia and class II MHC molecules H2-Kb, H-2Db, and CIITA mediate partial but incomplete virus clearance during acute lymphocytic choriomeningitis virus infection. Clearance is incomplete and chronic infection follows.
Data reveal how IFN-gamma modulates myogenesis and demonstrates a key role for CIITA in this process.
CIITA mutations alter the immune response without affecting fibrosis
Findings indicate that activation of CIITA pIII plays an important role in MHC class II expression in mast cells.
The results showed that PR8 selectively affects IFN-gamma induced MHC-II and iNOS expression in both the murine macrophage-like cell line, Raw264.7, and in primary alveolar macrophages.
data reveal a novel role for CIITA in endothelial cells and present SUV39H1 as a druggable target in the intervention of endothelial dysfunction
CIITA expression is higher when carried by FP single recombinants than when combined with FPgp or FPenv constructs and can induce HLA-DR cell surface expression. However, in-vivo experiments did not show any significant increase in the humoral response. As CIITA already proved to elicit immunogenicity by improving antigen presentation, further in-vivo experiments should be performed to increase the immune responses
Therefore, our data identify HIC1 as a novel factor involved in B cell differentiation acting as an epigenetic repressor of CIITA transcription.
B. abortus lipoproteins via IL-6 inhibit the expression of IFN regulatory factor 1 (IRF-1), a critical regulatory transcription factor for CIITA induction.
Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison.
CLPTM1L and TERT have been implicated in cancers, and CIITA is considered as the "master control factor" for the expression of NPC-associated MHC class II genes. These suggested that both SNPs might be functional. Altogether, our findings expand our understanding of the genetic contribution to NPC risk and provide novel biological insights into NPC pathogenesis.
When mouse pDCs and CAL-1 cells were stimulated by GM-CSF, mRNA levels of PU.1, pIII-driven CIITA, total CIITA, MHC class II, and the amount of PU.1 binding to pIII were significantly increased
the MHC2TA -168 A/G polymorphism is not associated with susceptibility to rheumatoid arthritis in Caucasians [meta-analysis]
Observed no association between the MHC2TA or FCRL3 SNPs and rheumatoid arthritis in Mexican patients.
CIITA acts as a general restriction factor against HIV-1 not only in T cells but also in myeloid cells.
CIITA gene alterations are a common mechanism of immune escape through reduction of MHC class II expression in primary mediastinal large B cell lymphoma.
CIITA Isoform III interacts more efficiently with components of the transcription machinery and MHC-II promoter binding proteins.
The dimerization region of Epstein-Barr virus Zta is not required to mediate host CIITA repression.
Thus, CIITA inhibits cytoplasmic and nuclear steps of human T cell lymphotropic virus type 1 Tax-1-mediated NF-kappaB activation.
FOXP1 represents a novel regulator of genes targeted by the class II MHC transactivator CIITA and CD74.
Lys(63) ubiquitinated CIITA is concentrated in the cytoplasm and following activation of ERK1/2, CIITA phosphorylation occurs and Lys=ubiquitinated CIITA translocates to the nucleus.
Genomic alterations underlying immune privilege in malignant lymphomas prominently include structural genomic changes of the CIITA and CD274 loci. (Review)
19S ATPases have nonproteolytic roles in transcription of CIITApIV genes
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction.
class II, major histocompatibility complex, transactivator
, class II transactivator-like
, class II transactivator
, MHC class II transactivator-like
, MHC class II transactivator
, MHC class II transactivator type III
, NLR family, acid domain containing
, nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
, MHC class II transactivator type IV