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Human Polyclonal GRIK5 Primary Antibody pour IHC, ELISA - ABIN1002381
Tanaka: Functions of glutamate transporters in the brain. dans Neuroscience research 2000
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Human Polyclonal GRIK5 Primary Antibody pour IHC (p), WB - ABIN541329
Herb, Burnashev, Werner, Sakmann, Wisden, Seeburg: The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. dans Neuron 1992
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Rat (Rattus) Polyclonal GRIK5 Primary Antibody pour IHC, WB - ABIN1742375
Marrocco, Mairesse, Ngomba, Silletti, Van Camp, Bouwalerh, Summa, Pittaluga, Nicoletti, Maccari, Morley-Fletcher: Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
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Cow (Bovine) Polyclonal GRIK5 Primary Antibody pour ELISA - ABIN451808
Fotheringham, Williams, Akhyani, Jacobson: Human herpesvirus 6 (HHV-6) induces dysregulation of glutamate uptake and transporter expression in astrocytes. dans Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2008
Authors present evidence that the ER retention signals in the kainate receptors containing GluK5 impose a requirement for sorting into local dendritic secretory pathways in neurons, as opposed to traversing the somatic Golgi apparatus.
The AA genotype of GRIK5 had a protective effect against chronic obstructive pulmonary disease.
CaMKII-dependent phosphorylation of GluK5 is responsible for synaptic depression by untrapping of KARs from the PSD and increased diffusion away from synaptic sites.
characterization the trafficking and surface expression of KA2
GRIK 5 gene is linked to rapid-onset dystonia-parkinsonism.
Functional dysregulation of glutamate uptake was associated with early increases in mRNA and protein expression of the glial glutamate transporter EAAT-2 followed by a sustained decrease in mRNA expression in astrocytes infected with both HHV-6A & HHV-6B.
This study demonistrated that Grik5 gene expression in mouse dorsal raphe nucleus
Postsynaptic and presynaptic mossy-fiber kainate receptor function is altered in neurons from KA2-/- mice; presynaptic facilitatory autoreceptor had a reduced affinity for exogenous agonists and synaptic glutamate
Association between COPI proteins and KA2 subunits was significantly reduced upon alanine substitution of this signal in the cytoplasmic tail of KA2.
Trafficking motifs in both intracellular loop and C terminus regulate KA2 surface expression; however, in neurons, GluR6 oligomerization is required for egress of KA2 from endoplasmic reticulum and transport to cell surface.
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.
excitatory amino acid receptor 2
, glutamate receptor KA-2
, glutamate receptor KA2
, glutamate receptor ionotropic, kainate 5
, glutamate receptor, ionotropic, kainate 5
, kainate type glutamate receptor 6
, glutamate receptor, ionotropic, kainate 2
, glutamate receptor ionotropic kainate 5
, glutamate receptor, ionotropic kainate 5
, glutamate receptor, ionotropic kainate 2
, ionotropic glutamate receptor subunit KA2
, gluR gamma-2
, glutamate receptor gamma-2