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The C (minor) allele decreased EPHA2 transcriptional activity relative to the T allele by reducing the binding affinity of PAX2 to the EPHA2 promoter region.
PAX2 is dispensable for mesenchymal-to-epithelial transition of nephron progenitors, but is required for morphological development of glomerular parietal epithelial cells, during nephron formation from human iPS cells in vitro.
Our data suggested that high expression of PAX2 could be associated with better survival in estrogen receptor positive tamoxifen-treated breast carcinoma patients.
During the ensuing weeks, the PAX2/FOXA1 boundary progressively extended cranially such that by 21 weeks the entire vaginal epithelium was FOXA1-reactive and PAX2-negative. This observation supports Bulmer's proposal that human vaginal epithelium derives solely from urogenital sinus epithelium
PAX2 is involved in the carcinogenesis of endometrial cancer by stimulating cell growth and promoting cell motility; the overexpression of PAX2 in endometrial cancer is regulated by promoter hypermethylation and the transcription factor MZF1
This case unravels a previously unrecognized phenotype of camptodactyly due to a significant skeletal deformity of Papillorenal syndrome with a heterogeneous PAX2 mutation of hexanucleotide duplication.
Mutant p53 and PTEN loss negatively regulated PAX2 and PAX2 re-expression in high-grade serous ovarian cancer cells induced cell death.
The polymorphism rs12266644 of PAX2 might be a risk factor for mullerian duct anomalies in Chinese Han females
PAX2, PAX8, CDX2 immunostains was preformed to the TMA slides.
we demonstrated that miR-497 is decreased in human ovarian cancer tissues and cells, and acts as a tumor suppressor. We also confirmed PAX2 is a target gene of miR-497
Vimentin, Nestin and WT1. Sox2 was expressed by the stem/progenitor cells of the ventricular zone, whereas the postmitotic neurons of the cortical plate were immunostained by PAX2 and NSE.
PAX2 and PAX5 are useful biomarker in the differential diagnosis of lung cancer
a substantial minority of solitary fibrous tumors express nuclear PAX8 and PAX2
PAX2 gene silencing can significantly inhibit the process of epithelial-mesenchymal transition (EMT) of renal tubular cells in rats with advanced fibrosis.
The results of this study identify several new mutations of PAX2, and sequence variants in four additional genes, including a novel potentially pathogenic mutation in KIF26B, which may play a role in the pathogenesis of Renal Coloboma Syndrome.
data suggested the differential regulation of hDAO expression by two promoters whose activities may be modulated by the binding of PAX2 and PAX5
Homozygosity for the risk alleles of RET and PAX2 was not seen in the late onset group in primary hyperoxaluria type 1 patients.
PAX2 and PAX8 are useful biomarker in the differential diagnosis of ovarian serous and mucinous tumors
The 798C>T/909A>C PAX2 genotype did not increase the susceptibility to HenochSchonlein purpura (HSP), but it was likely to increase the susceptibility of kidney involvement in HSP patients.
Novel PAX2 targets included multiple genes encoding proteins with predicted functions in the epididymis epithelium.
High fat diet-caused renal injury involved the inactivation of Pax2 and Ampk, and the activation of soluble epoxide hydrolase (sEH), in a murine model.
Pax2 (and Sox2) are both expressed in the prosensory cells, the developing hair cells of the vestibular and auditory sensory organs.
Paired box protein Pax-2 (Pax2)EGFP expression indicates the location of hair cells at the organoid region.
results identify the LSD1/NuRD complex as a previously unrecognized modulator for Pax2-mediated neuronal differentiation in the inner ear
Demonstrate the stepwise emergence of hitherto undescribed, differently Pax2/Pax8- coded anterior and posterior subdomains in the posterior placodal area of mice.
Pax2 function maintains nephron progenitor cells by repressing a renal interstitial cell program.
Pax2-regulated ISL1 overexpression increases the embryonic ISL1(+) domain and induces accelerated nerve fiber extension and branching in E12.5 embryos.
PAX2 may not be a classical oncogene or tumor suppressor but instead can act in either role by differential regulation of COX2 and/or HTRA1.
Dicer ablation in the early metanephric mesenchyme results in severe renal dysgenesis despite normal initial specification of nephron progenitors and ureteric bud outgrowth.
Pax2 specifies the intermediate mesoderm and renal epithelial cells through epigenetic mechanisms and in part by repressing paraxial mesodermal fate.
Data indicate hyperproliferation, impaired differentiation and increased apoptosis of neural progenitors in the cerebellum of lethal giant larvae homolog 1 (Lgl1)-Pax2 protein knockout embryos.
a core regulatory subcircuit composed of Pax2/8, Gata3 and Lim1 turns on a deeper layer of transcriptional regulators while activating effector genes responsible for cell signaling and tissue organization.
the role of Pax2 protein levels in determining correct renal architecture and cell fate in urogenital development.
cross-talk between p53 and Pax2 provides a transcriptional platform that promotes nephrogenesis, thus contributing to nephron endowment
Hnf1b and Pax2 operate to control kidney morphogenesis and ureter differentiation.
Hyperactivated Wnt signaling increased expression of the transcription factor Pax2 in the cells lining cysts in autosomal dominant polycystic kidney disease.
Pax2 is essential for mouse development and regulates prostatic ductal growth, branching, and lobe-specific identitiy.
These results suggest that PAX2 is a strong candidate gene for cases in which human patients have optic disc coloboma not associated with renal dysplasia.
A high incidence of urinary tract anomalies in Pax2;Emx2 were found in compound heterozygous mice that are not found in single heterozygous mice.
Pax2 is required after the establishment of the tubule pronephric anlage, for the expression of several terminal differentiation markers of the pronephric tubule.
pax2 transcription factor cooperates in patterning the Xenopus brain.
Pax2a and Pax8 regulate cell differentiation during sensory placode formation
Pax2 regulates a fadd-dependent molecular switch that drives tissue fusion during eye development
pax8 works with related genes pax2a/pax2b to downregulate otic expression of foxi1, a necessary step for further otic development
wnt1 and wnt10b are required to maintain threshold levels of Pax2.1 and Fgf8 at the midbrain-hindbrain boundary.
hhex, nk2.1a, and pax2.1 regulate thyroid growth and differentiation downstream of Nodal-dependent transcription factors.
Pax2.1 is not only involved in initiating but also in maintaining the identity of midbrain and isthmus cells to prevent them from assuming a forebrain or hindbrain fate.
Pax2a and Pax8 are the main effectors downstream of Fgf signals in ear formation
pax8 is initially required for normal otic induction, and subsequently pax8, pax2a and pax2b act redundantly to maintain otic fate
Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons.
PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor supressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.
paired box homeotic gene 2
, paired box protein Pax-2
, optic disc coloboma
, paired box gene 2
, paired box protein Pax-2-A
, no isthmus protein
, paired box gene 2.1
, paired box homeotic gene 2a
, paired box protein Pax-2a