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anti-Human ACTN1 Anticorps:
anti-Mouse (Murine) ACTN1 Anticorps:
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Mouse (Murine) Polyclonal ACTN1 Primary Antibody pour IHC, WB - ABIN3021587
Zhang, Xu, Xu, Wei, Xu: Protein kinase A inhibitor, H89, enhances survival and clonogenicity of dissociated human embryonic stem cells through Rho-associated coiled-coil containing protein kinase (ROCK) inhibition. dans Human reproduction (Oxford, England) 2016
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Human Polyclonal ACTN1 Primary Antibody pour IHC, WB - ABIN6672562
Zhang, Xu, Xu, Wei, Xu: Protein kinase A inhibitor, H89, significantly enhances survival rate of dissociated human embryonic stem cells following cryopreservation. dans Cell proliferation 2017
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Human Monoclonal ACTN1 Primary Antibody pour ELISA, WB - ABIN559761
Quick, Skalli: Alpha-actinin 1 and alpha-actinin 4: contrasting roles in the survival, motility, and RhoA signaling of astrocytoma cells. dans Experimental cell research 2010
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Human Monoclonal ACTN1 Primary Antibody pour ICC, IF - ABIN4279827
Shen, Soibam, Benham, Xu, Chopra, Peng, Yu, Bao, Liang, Azares, Liu, Gunaratne, Mercola, Cooney, Schwartz, Liu: miR-322/-503 cluster is expressed in the earliest cardiac progenitor cells and drives cardiomyocyte specification. dans Proceedings of the National Academy of Sciences of the United States of America 2016
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Human Monoclonal ACTN1 Primary Antibody pour IF, IHC - ABIN2715972
Shuliang, Lei, Guangwu, Changjie: Involvement of ubiquitin-conjugating enzyme E2C in proliferation and invasion of prostate carcinoma cells. dans Oncology research 2014
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Human Polyclonal ACTN1 Primary Antibody pour IHC (p), IHC - ABIN442543
Hosseinibarkooie, Peters, Torres-Benito, Rastetter, Hupperich, Hoffmann, Mendoza-Ferreira, Kaczmarek, Janzen, Milbradt, Lamkemeyer, Rigo, Bennett, Guschlbauer, Büschges, Hammerschmidt, Riessland, Kye et al.: The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype. ... dans American journal of human genetics 2016
Dog (Canine) Polyclonal ACTN1 Primary Antibody pour IHC, IHC (p) - ABIN4279828
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. dans Nature methods 2013
EFA6A recruits alpha-actinin 1 (ACTN1) through direct binding.
ACTN1 mutations lead to a benign form of platelet macrocytosis not always associated with thrombocytopenia.
During sperm capacitation, the F-actin severing proteins gelsolin and cofilin are inactive and they undergo activation prior to the acrosomal exocytosis. (Review)
Recent discoveries highlight that a small but rapidly growing set of actin nucleators and related proteins, i.e. factors that have the power to promote the formation of new actin filaments in cells, are tightly controlled by the Ca2+ sensor protein CaM. (Review)
By means of next-generation sequencing, two missense variants in cis in the ACTN1 gene of affected family members with familial macrothrombocytopenia were identified, both of unknown significance
these results indicate that increased alpha-actinin-1 expression destabilizes E-cadherin-based adhesions, which is likely to promote the migratory potential of breast cancer cells. Furthermore, our results identify a-actinin-1 as a candidate prognostic biomarker in basal-like breast cancer.
These results demonstrate that both actinin-1 and actinin-4 participate in the assembly of F-actin at invadopodia. Additionally, actinin-4 may have a selective advantage in accelerating invadopodia-mediated invasion of carcinoma cells.
provide a structural model of regulation of the actin crosslinking activity of alpha-actinin-1 where calcium induced structural stabilisation causes fastening of the juxtaposed actin binding domain, leading to impaired capacity to crosslink actin
our 11 patients with macrothrombocytopenia related to ACTN1 mutation are characterized by an isolated autosomal dominant mild thrombocytopenia, with low bleeding tendency.
Calcium modulates calmodulin-ACTN1 interaction with and agonist-dependent internalization of the adenosine A2A receptor.
Actinin-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression
This suggests that a precise dosage of PC2 is necessary for an adequate mechanosensitive alpha-actinin recruitment at junctions.
The present study identified a de novo mutation in ACTA1 (c.350A>G; p.Asn117Ser) in a Chinese patient using targetcapture sequencing of a panel containing 125 known causal genes for inherited muscle diseases.
Drp1 is in dynamic equilibrium on mitochondria in a fission-independent manner, and that fission factors such as actin filaments target productive oligomerization to fission sites.
Host cortactin, PKD1 and actin are recruited by Trypanosoma cruzi extracellular amastigotes based on experiments in fixed and live cells by time lapse confocal microscopy.
The authors show that the microtubule binding protein EB1 (end-binding protein 1), a key regulator of microtubule dynamics, can bind directly to filamentous actin (F-actin) F-actin.
Several dominantly inherited congenital macrothrombocytopenia-associated mutations that are located within the actinin-1 actin-binding domain cause increased binding of actinin-1 to actin filaments and enhance filament bundling in vitro.
Data indicate that alpha-actinin (110 kDa) autoantibody was characterized as a major target in lupus nephritis (LN) patients positive for Anti-membrane autoantibodies (MbA).
ACTN1 determines the motility of keratinocytes by regulating the organization of the actin cytoskeleton, focal adhesion, and hemidesmosome proteins complexes, thereby modulating cell speed, lamellipodial dynamics, and directed migration
ArgBP2 interaction with alpha-actinin and actin stress fibers inhibits cell migration
The data point to a surprising scenario where local assembly and biased polymerization generate the slow axonal transport of actin without involvement of microtubules (MTs) or MT-based motors.
NIK is an essential post-transcriptional regulator of T-cell activation affecting F-actin dynamics and TCR signaling.
It is shown that TNF-alpha signaling regulates the phosphorylation of serine-5 and -7 in L-plastin which increases the actin bundling capacity of L-plastin and hence the formation of nascent sealing zones in mouse osteoclasts.
The data suggested that Daam1 affected actin assembly during oocyte meiotic division via the regulation of fascin expression.
Interactions with phosphatidylinositol 4,5-bisphosphate decrease the actin polymerizing activity of Ig domain 3 of palladin (Palld-Ig3).
Furthermore, this F-actin mesh network attached to the synaptic ribbons directly influences the efficiency of otoferlin-dependent exocytosis and its sensitivity to intracellular hydrostatic pressure.
These findings evidence alpha-actinin involvement in sarcomeric development, suggesting for this protein an important role in stabilizing the muscle contractile apparatus.
The C-terminal polybasic region of CYTH2 participates in interacting directly with the EFh2 domain of ACTN1.
Actn1 differential methylation occurs in diverse mouse tissues. Authors have found no indication of an imprinted effect on gene expression of Actn1 in mice.
alpha-actinin has a role in adhesion maturation through integrin-dependent force transmission to the extracellular matrix
Alpha-actinin interaction with syndecan-4 has a role in stabilising cell-matrix adhesion.
the SRF-cofilin-actin signaling axis modulates neuronal mitochondrial function
vinculin engagement of adhesion receptors first activates talin or alpha-actinin, by provoking structural changes that allow their vinculin binding sites to swing out, which are then sufficient to bind to and activate vinculin
EFA6A may form a protein complex with alpha-actinin and activate ARF6 in close proximity of the actin cytoskeleton and membrane proteins in the dendritic spines
there is an alpha-actinin-1-dependent mGlu(5b) receptor association with the actin cytoskeleton modulating receptor cell surface expression and functioning
Surface biotinylation and flow cytometry assays revealed that L-type calcium channel alpha(1C) channels composed of the corresponding alpha-actinin-binding-deficient mutants result in a 35-40% reduction in surface expression compared to that of wild-type channels.
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
actinin, alpha 1
, alpha actinin
, F-actin cross-linking protein
, actinin 1 smooth muscle
, alpha-actinin cytoskeletal isoform
, non-muscle alpha-actinin-1
, alpha actinin 1a
, non-muscle alpha-actinin 1
, alpha-actinin 1