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Human Laminin alpha 5 Kit ELISA pour Sandwich ELISA - ABIN417805
Laudanski, Charkiewicz, Kuzmicki, Szamatowicz, ?wi?tecka, Mroczko, Niklinski: Profiling of selected angiogenesis-related genes in proliferative eutopic endometrium of women with endometriosis. dans European journal of obstetrics, gynecology, and reproductive biology 2013
Show all 2 Pubmed References
Both in cell lines and in mouse model, the extracellular matrix receptors including the integrin ( ITGA3 (Montrer ITGA3 Kits ELISA) and ITGA2B), collagen ( COL5A1 (Montrer COL5A1 Kits ELISA)), and laminin ( LAMA5) were significantly inhibited by curcumin at messenger RNA and protein levels.
The Laminin-511 consists of alpha5, beta1, and gamma1 chains, of which three laminin globular domains of the alpha5 chain (alpha5/LG1-3) and a Glu (Montrer DCTN1 Kits ELISA) residue in the C-terminal tail of chain gamma1 (gamma1-Glu1607) are required for binding to integrins.
The association of LAMA5 rs4925386 alleles with both inter-individual differences in height and in longevity suggests that laminins may be among the factors linking stature and cancer susceptibility.
disruption of the LAMA5 gene dramatically reduced hPSC self-renewal and increased apoptosis without affecting the expression of pluripotency markers.
Gal-1 (Montrer LGALS1 Kits ELISA) decreased the expression of collagen genes COL3A1 (Montrer COL3A1 Kits ELISA) and COL5A1 (Montrer COL5A1 Kits ELISA) but increased the expression of fibronectin (Montrer FN1 Kits ELISA) and laminin 5.
Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM (Montrer BCAM Kits ELISA)), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes.
mechanistic role of laminin-511 in tissue homeostasis
Polymorphisms in LN5 were associated with a reduced level of hemoglobin and neutropenia in non-small cell lung cancer.
PDGF (Montrer PDGFA Kits ELISA)-BB is not superior to laminin as a potential marker of advanced CP.
Data indicate that the function-blocking antibody against Lu/B-CAM (Montrer BCAM Kits ELISA) should be useful for not only investigating cell adhesion to laminin alpha5 but also for developing drugs to inhibit sickle cell vaso-occlusion.
The authors show that the integral endothelial basement membrane component, laminin 511 (laminin alpha5), is central to shear detection and mechanotransduction and its elimination at this site results in ablation of dilation in response to increased shear stress.
According to the results, it seems that maternal nicotine exposure may induce abnormal laminin alpha 5 expression which may cause defects in kidney function during life time.
Data suggest that the proper expression of laminin-332 (Lamb3 (Montrer LAMB3 Kits ELISA)) and laminin-511 (lama5) may regulate appropriate hair morphogenesis.
Laminin alpha 5 (Lama5) mRNA expressions in the lung of newborn in the nicotine treated Exp D1 decreased by 0.63 fold.
crystal structure of laminin alpha5LN-LE1-2 fragment shows the LN domain is a beta (Montrer SUCLA2 Kits ELISA)-jelly roll with several elaborate insertions; surface loop is required for stable ternary association with the beta- and gamma-short arms in the laminin network
Data provides support for a primary role of laminin-511 and integrin beta-1 (Montrer ITGB1 Kits ELISA) promoting hair follicle epithelial downgrowth without affecting dermal primary cilia and Shh (Montrer SHH Kits ELISA) target gene induction.
Downregulation of laminin-511 is important for hair regression.
several peptides of Laminin alpha 5 had cell attachment activity and the ability to promote neurite outgrowth.
Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.
, laminin subunit alpha-5
, unm m538
, laminin, alpha 5
, laminin subunit alpha-5-like
, laminin alpha-5 chain
, laminin-10 subunit alpha
, laminin-11 subunit alpha
, laminin-15 subunit alpha