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Brain tumor expression of nectin-1 may be a useful biomarker to predict patient response to oHSV.
Breast cancer patients with lower expression levels of either PRR11 or SKA2, along with wild type p53, exhibited better disease-free survival compared to others with p53 mutations and/or higher expression levels of either PRR11 or SKA2. Study indicates that the PRR11 and SKA2 transcription unit might be an oncogenic contributor.
Study provides evidence that high expression of Nectin-1 in breast neoplasm was associated with lymph node metastasis, advanced disease stage (UICC III and IVA) and significant higher rates of disease recurrence or death regardless of TN stage, grade of tumor differentiation, metastasis, vascular, and perineural invasion.
this is the first report showing an association between nectin1 expression and histological subtypes of gastric cancer
Pseudorabies virus infects host cells via both human and swine nectin-1.
In a transgenic mouse line with high expression of nectin-1Ig, significant protection from the infection with 30 and 300 MLD50 was observed .
nectin-1 is expressed in human hair follicles and there is a p63-responsive element in the NECTIN1 promoter
The viral entry receptor Nectin-1 is also internalized during HSV-1 infection in a Cbl-dependent mechanism, and that increases the opportunity of the virus to spread to uninfected cells.
HSV gD is able to disrupt intercellular homophilic trans-interaction of nectin-1 and induce a rapid redistribution of nectin-1 from cell junctions.
PVRL1 variants make a contribution to non syndromic Cleft Lip with/without Cleft palate in Turkish patients.
PDZD11 forms a complex with nectin-1 and nectin-3, and its PDZ domain interacts directly with the PDZ-binding motif of nectin-1.
mutations in exons 2 and 5 of PVRL1, and T334A, A391T, G1183A in the alpha-spliced transcript, and G1082T in the beta-spliced transcript do not participate in the development of non-syndromic cleft of the lip and/or palate in patients from Guangdong.
data suggests that E-cadherin regulates assembly of nectin junctions through alpha-catenin-induced remodeling of the actin cytoskeleton around the cadherin clusters.
The results showed that the interface between the BV gD and nectin-1 molecule is not geometrically complementary.
These data provided solid structural and functional evidence that herpes simplex virus 1 and herpes simplex virus 2 gD proteins recognize nectin-1 via the same binding mode.
Authors show that the same key residues in the BC and FG loops of nectin-4 govern binding to the measles virus attachment protein hemagglutinin (H) and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1.
Host nectin-1 is required for efficient Chlamydia trachomatis serovar E development.
These results suggest that HVEM might play more important roles than CD28 in ConA-mediated T cell proliferation
We identified new supportive evidence that the association between PVRL1 gene and nsCL/P in Turkish patients.
Glycoprotein D (gD) epitope core structure maps to the external surface of herpesvirus (HSV) gD, corresponding to the binding sites of two receptors, herpesvirus entry mediator (HVEM) and nectin-1, which mediate HSV infection.
finding suggests that necroptosis is responsible for GalN/LPS-induced liver injury through DAMP-activated PRR signaling.
Nectin-1 promotes chlamydial infection in the female genital tract but does not appear to contribute to rectal infection in male mice.
nectin-1 regulates the neuronal activities in the CA3 region of the hippocampus.
Novel type of cell adhesion apparatus is mediated by Nectin-1 and Nectin-4. It's implicated in prolactin receptor signaling for mammary gland development.
The synergistic action of nectins generates mosaic pattern, which cannot be achieved by a single mechanism.
These results indicate that the nectin-1 spots regulate the branching of mitral cell dendrites in the deep sub-lamina of the EPL and suggest that the nectin-1 spots are required for odor information processing in the olfactory bulb.
Results indicate that the nectin-1 spots constitute a novel adhesion apparatus that tethers mitral cell dendrites in a dendritic meshwork structure of the developing mouse olfactory bulb
results demonstrate a role for both nectin-1 and HVEM as receptors and suggest a further receptor which appears much less efficient.
Pvrl1 is a bona fide target gene of the transcription factor p63, whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6
In summary, herpes simplex virus 1 entry into epidermis was shown to strongly depend on the presence of nectin-1, but the restricted presence of HVEM can potentially replace nectin-1 as a receptor.
This study demonstrated that nectin1- and nectin3-mediated interactions between Cajal-Retzius cells cells and migrating neurons are critical for radial migration
PRR1 nectin-1 plays a role in the formation of intimal thickening after carotid artery ligation.
Nectin-1-specific entry of herpes simplex virus 1 is sufficient for infection of the cornea and viral spread to the trigeminal ganglia.
These results suggest that differences in nectin-1 and HVEM receptor expression between adults and newborns may partially explain differences in susceptibility to herpes simplex 2.
Loss of presenilin 1/gamma-secretase activity delays processing of nectin-1 and causes accumulation of its full-length and carboxyl-terminal fragments.
The authors report that either HVEM or nectin-1 must be present for HSV-1 infection of the cornea.
hair cells and supporting cells express nectin-1 and -3, respectively; their interaction mediates the heterotypic adhesion between these 2 cell types; nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia
Results suggest that heterophilic interaction between nectin-1 and nectin-3 recruits desmosomal junctions, and that these are required for proper enamel formation.
Nectins asymmetrically localize at puncta adherentia junctions and at synaptic junctions. Inhibition of the nectin-based adhesion by an inhibitor of nectin results in a decrease in synapse size and a concomitant increase in synapse number.
Nectin-1alpha is an immunoglobulin-like receptor involved in the formation of synapses and is a substrate for presenilin/gamma-secretase-like intramembrane proteolytic activity
Contribution of the second and third Ig-like domains of nectin-1 was analysed by generating transgenic mice expressing the entire ectodomain of nectin-1 fused to the porcine Fc portion.
Results demonstrate that a soluble form of the first domain of porcine nectin-1 is able to exert a significant antiviral effect against pseudorabies virus infection.
This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.
ectodermal dysplasia 4 (Margarita Island type)
, herpes virus entry mediator C
, herpesvirus Ig-like receptor
, nectin 1
, poliovirus receptor-like 1
, poliovirus receptor-related protein 1
, poliovirus receptor-related 1 (herpesvirus entry mediator C; nectin)
, poliovirus receptor-related 1 (herpesvirus entry mediator C)
, Poliovirus receptor-related protein 1
, herpesvirus entry mediator C
, nectin-1 alpha
, nectin-1 delta
, poliovirus receptor-related 1 (herpesvirus entry mediator C
, poliovirus receptor-related 1
, poliovirus receptor related protein
, nectin 2
, nectin cell adhesion molecule 2 L homeolog
, poliovirus receptor-related 2 (herpesvirus entry mediator B) L homeolog