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SORBS1 suppresses tumor metastasis and improves the sensitivity of breast cancer cells to antineoplastic agents.
association between common SORBS1 genetic variations and blood pressure, presence of hypertension, and age at onset of hypertension
data suggest that SORBS1 might be a gene involved in diabetic nephropathy.
Our NMR and ITC data indicate that the SH3a and SH3b domains of CAP simultaneously bind to a long proline-rich region of vinculin with different binding specificities
Sequestration of the ponsin splice variant R85FL by the polyglutamine-expanded Atx7 in cell is mediated by the specific SH3C-PRR interaction, which is implicated in the pathogenesis of spinocerebellar ataxia 7.
a novel signaling network containing FRS2, CAP and flotillin-1
The novel ponsin isoform and its interaction with Nck1/2 provide exciting insight into the convergence of signalling pathways at the costameres, and its crucial role for skeletal muscle differentiation and re-generation.
regulates cytoskeletal organization and signal transduction--review
preliminary results indicate the depot-specific differential expression of sorbin and SH3 domain-containing-1(SORBS1) in relation to body mass index
SORBS1 polymorphism does not play a major role in premature pubarche, hyperandrogenism, and/or polycystic ovary syndrome in children and adolescent girls.
A novel isoform was identified in a yeast two-hybrid screen for A-kinase anchoring proteins expressed in the heart.
Soluble intracellular domain of teneurin-1 binds to the cell membrane enriched in CAP/ponsin
analysis of paxillin and ponsin interaction in nascent costameres of muscle cells
AA genotype of SORBS1 T228A polymorphism may play a role in lacunar infarction in the Japanese population.
These results suggest that SORBS1 and GCK are susceptibility loci for hypertension in Japanese women and that WISP1 is such a locus in men.
Mutation of Tyr326 altered the function of CAP during cell spreading.
Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
The first SNP rs29972765 is located in a gene desert on chromosome 18, about 72 kb upstream of Skor2 . The second SNP rs30415957 resides in the intron of Plce1.The remaining two SNPs (rs30768258 and rs31216810) are close to each other on chromosome 19, in the vicinity of Sorbs1. Knockdown of Sorbs1 by siRNA attenuates the induction of differentiation marker gene Prl8a2
The study screened CrkL binding proteins using RNA interference (RNAi) and identified Sorbs1 and Sorbs2 as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro.
Suggest a novel modulatory role for CAP in the heart as a key protein stabilizing antiviral type I interferon production, while protecting from excessive cytotoxic responses in CVB3 mediated endocarditis.
Low- and high-dose ursolic acid can improve the glycometabolism and differentiation of 3T3-L1 adipocytes with insulin resistance by up-regulating the expression of CAP.
CAP, Cbl iso-forms, and CrkII are not required components of insulin signaling to GLUT4 transporters
Bone marrow-specific Sorbs1 (Cap) gene deletion protects against high-fat diet-induced insulin resistance.
These data provide a mechanism for the lipid raft localization of TrkA and establish the importance of the CAP adaptor protein for nerve growth factor activation of the extracellular signal-regulated kinase and neuronal differentiation.
CAP provides another link between the myofibril cytoskeleton and the plasma membrane of muscle cells, and it may play a dynamic role in the regulation and maintenance of muscle structural integrity
Polymorphisms in promoter regions of PDHB, SORBS1, and EDG1 genes showing marbling-associated expression changes.
Plays a role in tyrosine phosphorylation of CBL by linking CBL to the insulin receptor. Required for insulin- stimulated glucose transport. Involved in formation of actin stress fibers and focal adhesions.
Fas-ligand associated factor 2
, SH3 domain protein 5
, SH3-domain protein 5 (ponsin)
, c-Cbl associated protein
, c-Cbl-associated protein
, sorbin and SH3 domain-containing protein 1