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These results showed that difference in the expression pattern and location of miR (Montrer MYLIP Protéines)-126-3p occurred at different stages of the bovine corpus luteum and that miR (Montrer MYLIP Protéines)-126-3p is an important regulator of talin2 (TLN2).
The central role of talin and vinculin (Montrer VCL Protéines) in cell adhesions suggests that the disintegration of the tissue in atherosclerosis could be partially driven by downregulation of these genes, leading to loosening of cell-ECM (Montrer MMRN1 Protéines) interactions and remodeling of the tissue.
data suggest a potential molecular link between TLN2 and camptodactyly pathogenesis.
Both TLN-1 (Montrer TLN1 Protéines) and TLN-2 levels correlate with tumorigenicity in human HCC (Montrer FAM126A Protéines), indicating that these molecules constitute important molecular targets for the diagnosis and/or treatment of hepatocellular carcinoma .
Data indicate the role of vinculin (Montrer VCL Protéines) in inducing the talin mediated integrin activation.
Talin1 has unique expression versus talin 2 in the heart and modifies the hypertrophic response to pressure overload.
Data show that SCGB3A1 (Montrer SCGB3A1 Protéines) was down-regulated in invasive compared with DCIS, whereas talin 2 (TLN2) and PTGS1 (Montrer PTGS1 Protéines) were up-regulated in invasive compared with DCIS.
This review discusses the general function of talin 1 (Montrer TLN1 Protéines) and talin 2, as well as vinculin (Montrer VCL Protéines)/metavinulin, with emphasis on what is understood about their role in the cardiac myocyte and in whole heart.
the differential concentration of CSF (Montrer CSF2 Protéines) and serum-talin 2 in the drug-refractory postencephalitic epilepsy group is an intractability-related phenomenon that might be involved in the development of RPEE
The F-actin binding capacity of Talin 2 is regulated by intrasteric occlusion of primary actin-binding determinants within the talin I/LWEQ module.
Talin2 may serve as the link between integrins and the sarcomeric cytoskeletonin stable adhesion complexes in mature striated (Montrer NSDHL Protéines) muscle.
Loss of all Tln (Montrer TLN1 Protéines) forms from the heart-muscle cell leads to myocyte instability and a dilated cardiomyopathy.
Binding of vinculin (Montrer VCL Protéines) to the R1-R3 region of the talin rod is important for focal adhesion stability.
Data indicate that talin mechanics are isoform specific so that expression of either talin-1 (Montrer TLN1 Protéines) or talin-2 modulates extracellular rigidity sensing.
Tln2(cd/cd (Montrer CTSD Protéines)) mice showed no major difference in body mass or the weight of the major organs compared to wild-type, although they displayed a mildly dystrophic phenotype.
Talin1 was concentrated in peripheral focal adhesions while talin2 was observed in both focal and fibrillar adhesions, and knock-down of talin2 compromised fibronectin (Montrer FN1 Protéines) fibrillogenesis
Fxr1 knockout hearts exhibit an up-regulation of desmoplakin and talin2 proteins, which is accompanied by severe disruption of desmosome as well as costamere architecture and composition in the heart
Depletion of talin2 in talin1-null cells did not affect the initiation of matrix-activated spreading or Src (Montrer SRC Protéines) family kinase activation, but abolished the extracellular matrix-integrin-cytoskeleton linkage, sustained cell spreading and adhesion.
demonstrate that testis and kidney express truncated talin 2 isoforms that lack the N-terminal half of the protein, and provide evidence for the developmentally regulated expression of the short testis-specific (Montrer AIF1 Protéines) talin 2 isoform in elongating spermatids
This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. This protein has a different pattern of expression compared to talin 1 but, like talin 1, is thought to associate with unique transmembrane receptors to form novel linkages between extracellular matrices and the actin cytoskeleton.