Aperçu des produits pour anti-HAP1 (HAP1) Anticorps

Mouse (Murine) Huntingtin Associated Protein 1 (HAP1) interaction partners

1. AOM (Montrer COL2A1 Anticorps), a colorectal cancer carcinogen, generates damage to the mitochondrial genome, and the BER enzyme APE1 (Montrer APEX1 Anticorps) is required to maintain its integrity.

2. This study also validated the interaction between HAP1 and Sec23A (Montrer SEC23A Anticorps) using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins

3. findings provide evidence that endogenous APE1 (Montrer APEX1 Anticorps) protects against ischemic infarction in both gray and white matter and facilitates the functional recovery of the central nervous system after mild stroke injury

4. HAP1 co-localizes with synapsin I (Montrer SYN1 Anticorps) in cortical neurons as discrete puncta

5. Suppression of Ape1/Ref-1 (Montrer APEX1 Anticorps) redox function leads to an increased cell surface retention of IL-12 (Montrer IL12A Anticorps) and enhances Th1 (Montrer HAND1 Anticorps) responses.

6. findings suggest that Hap1 is important for insulin (Montrer INS Anticorps) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (Montrer CACNA1C Anticorps), providing new insight into the mechanisms that regulate insulin (Montrer INS Anticorps) release from pancreatic beta-cells.

7. Is closely associated with upregulation of the Ref1 (Montrer THOC4 Anticorps)/Nrf2 (Montrer NFE2L2 Anticorps) signalling pathway.

8. Results show the stimulatory effect of PARP-1 (Montrer PARP1 Anticorps) on APE1 (Montrer APEX1 Anticorps)-dependent base excision repair (BER). PARP-1 (Montrer PARP1 Anticorps) and APE1 (Montrer APEX1 Anticorps) appear to have a functional interaction in BER since PARP-1 (Montrer PARP1 Anticorps) can stimulate the strand incision activity of APE1 (Montrer APEX1 Anticorps).

9. Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.

10. Hap1 interacts with Bcr (Montrer BCR Anticorps) on microtubules to regulate neuronal differentiation.

Human Huntingtin Associated Protein 1 (HAP1) interaction partners

1. HAP1 (Montrer APEX1 Anticorps) is expressed in endocrine cells of the human gut (Montrer GUSB Anticorps).

2. data fully support that HAP1 (Montrer APEX1 Anticorps) is a GKAP (Montrer DLGAP1 Anticorps), anchoring specifically to the cGMP-dependent protein kinase (Montrer CDK7 Anticorps) isoform Ibeta, and provide further evidence that also PKG (Montrer PRKG1 Anticorps) spatiotemporal signaling is largely controlled by anchoring proteins

3. HAP1 (Montrer APEX1 Anticorps) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity

4. Overexpression of HAP1 (Montrer APEX1 Anticorps) reduced in vitro cell growth in breast cancer cell lines.

5. The results of this study found no association was found between the HAP1 (Montrer APEX1 Anticorps) T441M polymorphism and the age at onset of Huntington's disease .

6. The results of this study suggested that HAP1 (Montrer APEX1 Anticorps) co-localizes and associates with APP (Montrer APP Anticorps) in physiological conditions of mouse and human brain.

7. WT HTT (Montrer HTT Anticorps) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (Montrer PCM1 Anticorps)).

8. HAP1 (Montrer APEX1 Anticorps)/stigmoid body interacts with the normal ataxin-3 (Montrer ATXN3 Anticorps) through Josephin (Montrer ATXN3 Anticorps) domain

9. sortilin (Montrer SORT1 Anticorps) stabilizes the proBDNF.HAP1 complex

10. ADORA2A (Montrer ADORA2A Anticorps), but not HAP1 (Montrer APEX1 Anticorps) or OGG1 (Montrer OGG1 Anticorps), may have a role in age at onset in Huntington's disease