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Human Monoclonal HAP1 Primary Antibody pour ICC, FACS - ABIN259097
Chan, Nasir, Gutekunst, Coleman, Maclean, Maas, Metzler, Gertsenstein, Ross, Nagy, Hayden: Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. dans Human molecular genetics 2002
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Human Polyclonal HAP1 Primary Antibody pour IHC, ELISA - ABIN1002402
Borrell-Pagès, Zala, Humbert, Saudou: Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies. dans Cellular and molecular life sciences : CMLS 2006
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Monoclonal HAP1 Primary Antibody pour IHC (fro), IP - ABIN534035
Gutekunst, Torre, Sheng, Yi, Coleman, Riedel, Bujo: Stigmoid bodies contain type I receptor proteins SorLA/LR11 and sortilin: new perspectives on their function. dans The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2003
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Human Polyclonal HAP1 Primary Antibody pour ELISA, WB - ABIN188689
Takeshita, Fujinaga, Zhao, Yanai, Shinoda: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. dans Human molecular genetics 2006
HAP1 (Montrer APEX1 Anticorps) is expressed in endocrine cells of the human gut (Montrer GUSB Anticorps).
data fully support that HAP1 (Montrer APEX1 Anticorps) is a GKAP (Montrer DLGAP1 Anticorps), anchoring specifically to the cGMP-dependent protein kinase (Montrer CDK7 Anticorps) isoform Ibeta, and provide further evidence that also PKG (Montrer PRKG1 Anticorps) spatiotemporal signaling is largely controlled by anchoring proteins
HAP1 (Montrer APEX1 Anticorps) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity
Overexpression of HAP1 (Montrer APEX1 Anticorps) reduced in vitro cell growth in breast cancer cell lines.
The results of this study found no association was found between the HAP1 (Montrer APEX1 Anticorps) T441M polymorphism and the age at onset of Huntington's disease .
The results of this study suggested that HAP1 (Montrer APEX1 Anticorps) co-localizes and associates with APP (Montrer APP Anticorps) in physiological conditions of mouse and human brain.
WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1).
HAP1 (Montrer APEX1 Anticorps)/stigmoid body interacts with the normal ataxin-3 (Montrer ATXN3 Anticorps) through Josephin (Montrer ATXN3 Anticorps) domain
sortilin (Montrer SORT1 Anticorps) stabilizes the proBDNF.HAP1 complex
ADORA2A (Montrer ADORA2A Anticorps), but not HAP1 (Montrer APEX1 Anticorps) or OGG1 (Montrer OGG1 Anticorps), may have a role in age at onset in Huntington's disease
Depleting Huntingtin-associated protein 1 (Hap1) promoted the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A (Montrer DYRK1A Anticorps))-DDB1 and CUL4 associated factor 7 (Dcaf7 (Montrer DCAF7 Anticorps)) interaction and increased the DYRK1A (Montrer DYRK1A Anticorps) protein level.
This study also validated the interaction between HAP1 and Sec23A (Montrer SEC23A Anticorps) using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins
HAP1 co-localizes with synapsin I (Montrer SYN1 Anticorps) in cortical neurons as discrete puncta
findings suggest that Hap1 is important for insulin (Montrer INS Anticorps) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (Montrer CACNA1C Anticorps), providing new insight into the mechanisms that regulate insulin (Montrer INS Anticorps) release from pancreatic beta-cells.
Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.
Hap1 interacts with Bcr (Montrer BCR Anticorps) on microtubules to regulate neuronal differentiation.
HAP1 regulates exocytosis by influencing the morphological docking of vesicles at the plasma membrane, the ability of vesicles to be released rapidly upon stimulation, and the early stages of fusion pore formation.
these studies identify htt (Montrer HTT Anticorps) and HAP1 as regulators of autophagosome transport in neurons
In the absence of HAP1, postnatal hypothalamic neurons exhibited reduced receptor tropomyosin-related kinase B (TRKB (Montrer NTRK2 Anticorps)) levels.
Hap1-Tsc1 (Montrer TSC1 Anticorps) interaction regulates neuronal mTORC1 signaling and neuronal morphogenesis.
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, huntingtin-associated protein 2
, neuroan 1
, huntingtin-associated protein 1 (neuroan 1)