Aperçu des produits pour anti-HAP1 (HAP1) Anticorps

Human Huntingtin Associated Protein 1 (HAP1) interaction partners

1. HAP1 (Montrer APEX1 Anticorps) is expressed in endocrine cells of the human gut (Montrer GUSB Anticorps).

2. data fully support that HAP1 (Montrer APEX1 Anticorps) is a GKAP (Montrer DLGAP1 Anticorps), anchoring specifically to the cGMP-dependent protein kinase (Montrer CDK7 Anticorps) isoform Ibeta, and provide further evidence that also PKG (Montrer PRKG1 Anticorps) spatiotemporal signaling is largely controlled by anchoring proteins

3. HAP1 (Montrer APEX1 Anticorps) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity

4. Overexpression of HAP1 (Montrer APEX1 Anticorps) reduced in vitro cell growth in breast cancer cell lines.

5. The results of this study found no association was found between the HAP1 (Montrer APEX1 Anticorps) T441M polymorphism and the age at onset of Huntington's disease .

6. The results of this study suggested that HAP1 (Montrer APEX1 Anticorps) co-localizes and associates with APP (Montrer APP Anticorps) in physiological conditions of mouse and human brain.

7. WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1).

8. HAP1 (Montrer APEX1 Anticorps)/stigmoid body interacts with the normal ataxin-3 (Montrer ATXN3 Anticorps) through Josephin (Montrer ATXN3 Anticorps) domain

9. sortilin (Montrer SORT1 Anticorps) stabilizes the proBDNF.HAP1 complex

10. ADORA2A (Montrer ADORA2A Anticorps), but not HAP1 (Montrer APEX1 Anticorps) or OGG1 (Montrer OGG1 Anticorps), may have a role in age at onset in Huntington's disease

Mouse (Murine) Huntingtin Associated Protein 1 (HAP1) interaction partners

1. Depleting Huntingtin-associated protein 1 (Hap1) promoted the dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A (Montrer DYRK1A Anticorps))-DDB1 and CUL4 associated factor 7 (Dcaf7 (Montrer DCAF7 Anticorps)) interaction and increased the DYRK1A (Montrer DYRK1A Anticorps) protein level.

2. This study also validated the interaction between HAP1 and Sec23A (Montrer SEC23A Anticorps) using co-immunoprecipitation experiments with endogenous proteins. This manuscript also reports on the high confidence interacting partners of HAP1 identified by the non-biased approach used in this study, which interestingly, consists of predominantly trafficking-related proteins

3. HAP1 co-localizes with synapsin I (Montrer SYN1 Anticorps) in cortical neurons as discrete puncta

4. findings suggest that Hap1 is important for insulin (Montrer INS Anticorps) secretion of pancreatic beta-cells via regulating the intracellular trafficking and plasma membrane localization of Cav1.2 (Montrer CACNA1C Anticorps), providing new insight into the mechanisms that regulate insulin (Montrer INS Anticorps) release from pancreatic beta-cells.

5. Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.

6. Hap1 interacts with Bcr (Montrer BCR Anticorps) on microtubules to regulate neuronal differentiation.

7. HAP1 regulates exocytosis by influencing the morphological docking of vesicles at the plasma membrane, the ability of vesicles to be released rapidly upon stimulation, and the early stages of fusion pore formation.

8. these studies identify htt (Montrer HTT Anticorps) and HAP1 as regulators of autophagosome transport in neurons

9. In the absence of HAP1, postnatal hypothalamic neurons exhibited reduced receptor tropomyosin-related kinase B (TRKB (Montrer NTRK2 Anticorps)) levels.

10. Hap1-Tsc1 (Montrer TSC1 Anticorps) interaction regulates neuronal mTORC1 signaling and neuronal morphogenesis.