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anti-Human ABCA1 Anticorps:
anti-Rat (Rattus) ABCA1 Anticorps:
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Chicken Polyclonal ABCA1 Primary Antibody pour ChIP, ELISA - ABIN152883
Krimbou, Denis, Haidar, Carrier, Marcil, Genest: Molecular interactions between apoE and ABCA1: impact on apoE lipidation. dans Journal of lipid research 2004
Show all 259 Pubmed References
Chicken Polyclonal ABCA1 Primary Antibody pour ELISA, ICC - ABIN268847
Burgess, Kiss, Zheng, Zachariah, Marcel: Trypsin-sensitive and lipid-containing sites of the macrophage extracellular matrix bind apolipoprotein A-I and participate in ABCA1-dependent cholesterol efflux. dans The Journal of biological chemistry 2002
Show all 13 Pubmed References
Chicken Polyclonal ABCA1 Primary Antibody pour ELISA, IHC (fro) - ABIN268848
Murthy, Born, Mathur, Field: LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells. dans Journal of lipid research 2002
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Mouse (Murine) Monoclonal ABCA1 Primary Antibody pour IHC (p), WB - ABIN268899
Zhou, Choi, Li, Xu, Herz: LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export. dans PLoS ONE 2009
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Human Monoclonal ABCA1 Primary Antibody pour CyTOF, FACS - ABIN4277133
Wang, Zhang, Chou, Liang, Gu, Ma: Cyclosporine stimulates the renal epithelial sodium channel by elevating cholesterol. dans American journal of physiology. Renal physiology 2009
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Human Polyclonal ABCA1 Primary Antibody pour WB - ABIN3043773
Shang, Yu, Wang, Chen, Fang, Yang, Zhou, Nie, Zhou, Zhou: Fibroblast growth factor 21 enhances cholesterol efflux in THP-1 macrophage-derived foam cells. dans Molecular medicine reports 2014
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Human Polyclonal ABCA1 Primary Antibody pour WB - ABIN3044206
Chen: Effects of Chinese Herbal Compound "Xuemai Ning"on Rabbit Atherosclerosis Model and Expression of ABCA1. dans International journal of biomedical science : IJBS 2013
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Chicken Polyclonal ABCA1 Primary Antibody pour ELISA, FACS - ABIN446266
Ingram, Crowther, Little, Freeman, Harliwong, Veleva, Hassall, Remke, Taylor, Hallahan: ABC transporter activity linked to radiation resistance and molecular subtype in pediatric medulloblastoma. dans Experimental hematology & oncology 2013
Human Polyclonal ABCA1 Primary Antibody pour IF (p), IHC (p) - ABIN732188
Jia, Song, Yang, Ma, Li, Lu, Cao, Zhang, Zhu, Wang, Leng, Cao, Du, Xu: Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats. dans Molecular medicine reports 2016
Mouse (Murine) Monoclonal ABCA1 Primary Antibody pour FACS, IF - ABIN2477218
Zarubica, Trompier, Chimini: ABCA1, from pathology to membrane function. dans Pflügers Archiv : European journal of physiology 2007
identified HuR (Montrer ELAVL1 Anticorps) as a novel posttranscriptional regulator of ABCA1 expression and cellular cholesterol homeostasis, thereby opening new avenues for increasing cholesterol efflux from atherosclerotic foam macrophages and raising circulat-ing HDL (Montrer HSD11B1 Anticorps) cholesterol levels.
Hepatic ABCA1 deficiency results in increased hepatic triglyceride and ANGPTL3 (Montrer ANGPTL3 Anticorps) secretion, potentially underlying the elevated plasma triglyceride levels in Tangier disease patients.
ABCA1-derived nascent high-density lipoprotein-apolipoprotein AI (Montrer APOA1 Anticorps) and lipids metabolically segregate.
Hepatic free cholesterol content was significantly increased in NASH (Montrer SAMSN1 Anticorps) as compared to non-NASH (Montrer SAMSN1 Anticorps) subjects, while ABCA1 and ABCG1 (Montrer ABCG1 Anticorps) protein levels significantly decreased with NASH (Montrer SAMSN1 Anticorps) and fibrosis progression. The relative expression of miR (Montrer MLXIP Anticorps)-33a and miR (Montrer MLXIP Anticorps)-144 correlated inversely with ABCA1 but not with ABCG1 (Montrer ABCG1 Anticorps) protein levels. miR (Montrer MLXIP Anticorps)-33a/144 and their target gene ABCA1 may contribute to the pathogenesis of NASH (Montrer SAMSN1 Anticorps) in morbidly obese subjects.
Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC (Montrer ABCB6 Anticorps) transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases
ABCA1 was mainly located on trophoblast membranes. Decreased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.01). while increased ABCA1 expression in trophoblasts reduced the cholesterol efflux of trophoblasts (P < 0.05). ABCA1 was uniformly expressed on the cell membrane, cytoplasm, and nucleus of macrophages.
AMPK (Montrer PRKAA1 Anticorps) activates LXRalpha (Montrer NR1H3 Anticorps) and ABCA1 expression in human macrophages
Microparticles are lipoprotein-sized structures created by the ABCA1 transporter, and contribute approximately 30% of ABCA1-and apoA-I (Montrer APOA1 Anticorps) mediated cholesterol efflux. MPs release from cells consists, in part, of exosomes and depends on the same pathway used for HDL (Montrer HSD11B1 Anticorps) biogenesis.
there is an NFATc1 (Montrer NFATC1 Anticorps)/ABCA1-dependent mechanism in which local TNF (Montrer TNF Anticorps) is sufficient to cause free cholesterol-dependent podocyte injury irrespective of TNF (Montrer TNF Anticorps), TNFR1 (Montrer TNFRSF1A Anticorps), or TNFR2 (Montrer TNFRSF1B Anticorps) serum levels
Reduced platelet count, but no major platelet function abnormalities, are associated with loss-of-function ATP-binding cassette-1 gene mutations.
our results highlight the importance of the LXR (Montrer NR1H3 Anticorps)/ABCA1 system in brain pericytes and suggest a new role for these cells in brain cholesterol homeostasis.
The expression and distribution of the bovine ABCA1 transporter using quantitative PCR and the sequencing of the entire ABCA1 coding region, including the proximal promoter region, are reported.
Aortic endothelial cells transcytose high-density lipoproteins by mechanisms that involve either SR-BI (Montrer SCARB1 Anticorps) or ABCG1 (Montrer ABCG1 Anticorps) but not ABCA1.
ABCA1 promoter variants affect transcription activity and plasma HDL (Montrer HSD11B1 Anticorps) level in pigs
ABCA1 was up-regulated in monocytes of hypercholesterolemic pigs via oxidized-LDL and prior to development coronary atherosclerosis.
Both region-specific and ubiquitous (ABCA1) phenotype changes were identified as early prelesional responses of the endothelium to hypercholesterolemia
CSL112 elevation of ABCA1-dependent efflux may target atherosclerotic plaque for cholesterol removal.
demonstrates behavior deficits caused by Abca1 deletion in APP (Montrer APP Anticorps)/PS1DeltaE9 mouse model at an early stage of amyloid pathology. The basal deficits of Abca1ko, manifested by diminished cognitive performance, prevent them from coping with additional stressors, which is in part due to the impairment of neurite morphology in the hippocampus.
Rutaecarpine was identified to be a candidate that protected ApoE (Montrer APOE Anticorps)(-/-) mice from developing atherosclerosis through preferentially promoting activities of ABCA1 and SR-BI (Montrer SCARB1 Anticorps) within RCT (Montrer FOXE3 Anticorps).
Abca1 has a protective role in atherosclerosis, it exerts detrimental effects on cardiac function after myocardial infarction
Caveolin-1 (Montrer CAV1 Anticorps) enhances internalization and degradation of ABCA1 by its association with ABCA1
an important role for hepatic ABCA1 in regulating secretory trafficking and modulating VLDL expansion during the TG accretion phase of hepatic lipoprotein particle assembly
These studies showed that following brain ischemia, reactive astrocytes become phagocytic and engulf debris via the ABCA1 pathway.
PCSK9 (Montrer PCSK9 Anticorps) plays a direct role on Abca1-mediated cholesterol efflux through a downregulation of Abca1 gene and Abca1 protein expression. This extrahepatic effect may influence relevant steps in the pathogenesis of atherosclerosis, such as foam cell formation.
apoA-I (Montrer APOA1 Anticorps)/ABCA1-mediated cholesterol efflux without STAT3 (Montrer STAT3 Anticorps) activation can reduce proinflammatory cytokine expression in macrophages.
Our data indicate that a combination of vildagliptin and pravastatin significantly induces the expression of LXR (Montrer NR1H3 Anticorps)-ABCA1/ABCG1 (Montrer ABCG1 Anticorps) cascade and improves cholesterol efflux (P > 0.05) in adipocytes. Our data may explain, at least in part, the improvement in HDL (Montrer HSD11B1 Anticorps)-C levels observed in patients receiving both medications
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency.
ATP-binding cassette sub-family A member 1
, ATP-binding cassette transporter A1
, cholesterol efflux regulatory protein
, ATP-binding cassette, sub-family A (ABC1), member 1
, ATP-binding cassette, sub-family A member 1
, ATP-binding cassette transporter 1
, Cholesterol efflux regulatory protein
, ATP-binding cassette transporter
, ATP-binding cassette, sub-family A member 1-like
, ATP-binding cassette sub-family A member 1-like
, ATP-binding cassette 1