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anti-Human CX3CR1 Anticorps:
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Human Polyclonal CX3CR1 Primary Antibody pour CyTOF, FACS - ABIN4900502
Fan, Xiong, Zhang, Yan, Jian, Xu, Zhao: MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. dans Journal of the American Heart Association 2016
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Human Polyclonal CX3CR1 Primary Antibody pour ELISA, FACS - ABIN4301023
Aoyama, Inokuchi, Brenner, Seki: CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. dans Hepatology (Baltimore, Md.) 2010
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Mouse (Murine) Polyclonal CX3CR1 Primary Antibody pour FACS - ABIN4897825
Wattananit, Tornero, Graubardt, Memanishvili, Monni, Tatarishvili, Miskinyte, Ge, Ahlenius, Lindvall, Schwartz, Kokaia: Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2016
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Human Polyclonal CX3CR1 Primary Antibody pour FACS, IHC - ABIN110594
Held-Feindt, Hattermann, Mueerkoester, Wedderkopp, Knerlich-Lukoschus, Ungefroren, Mehdorn, Mentlein: CX3CR1 promotes recruitment of human glioma-infiltrating microglia/macrophages (GIMs). dans Experimental cell research 2010
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Human Polyclonal CX3CR1 Primary Antibody pour EIA, FACS - ABIN5554726
Wei, Cao, Yu, Liu, Wang: Overexpression of CX3CR1 is associated with cellular metastasis, proliferation and survival in gastric cancer. dans Oncology reports 2015
Human Monoclonal CX3CR1 Primary Antibody pour ELISA, WB - ABIN560540
Nevo, Sagi-Assif, Meshel, Ben-Baruch, Jöhrer, Greil, Trejo, Kharenko, Feinmesser, Yron, Witz: The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells. dans Cancer letters 2008
Human Polyclonal CX3CR1 Primary Antibody pour WB - ABIN411456
Kim, Rooper, Xie, Kajdacsy-Balla, Barbolina: Fractalkine receptor CX(3)CR1 is expressed in epithelial ovarian carcinoma cells and required for motility and adhesion to peritoneal mesothelial cells. dans Molecular cancer research : MCR 2012
Human Monoclonal CX3CR1 Primary Antibody pour FACS - ABIN4896932
Falk, Singh, Faber, Nissen, Hviid, Sørensen: CX3CL1/CX3CR1 and CCL2/CCR2 chemokine/chemokine receptor complex in patients with AMD. dans PLoS ONE 2014
Mouse (Murine) Polyclonal CX3CR1 Primary Antibody pour FACS - ABIN4897821
Arieta Kuksin, Gonzalez-Perez, Minter: CXCR4 expression on pathogenic T cells facilitates their bone marrow infiltration in a mouse model of aplastic anemia. dans Blood 2015
The results indicated that the absence of CX3CR1/CX3CL1 signaling in the central nervous system (CNS) may worsen neurodegeneration. The CX3CL1/CX3CR1 communication system has anti-inflammatory and neuroprotective effects and plays an important role in maintaining autophagy activity.
Study shows that homozygocity of the M280 polymorphism in CX3CR1 is a potentially novel population-based genetic factor that influences human monocyte signaling.
the roles of CX3CR1 in hepatic macrophages and liver injury, are reported.
In OvCa cells, CX3CR1 was upregulated in a process involving hypoxia-mediated regulation of HIF-1alpha. The elevated levels of CX3CR1, which were sensitive to CX3CL1, increased EMT markers that led to the progression and metastasis of OvCa.
Whisker lesioning induces microglia-mediated synapse elimination. This is dependent on signaling by CX3CR1, the receptor for microglial fractalkine.
CX3CR1 and CX3CL1 may have roles in deep vein thrombosis-associated endothelial dysfunction
cytokines up-regulate CX3CR1 expression on human monocytes by different intracellular mechanisms.
CX3CR1 role in renal diseases.[review]
This study shows that CX3CR1 T280M polymorphism does not affect the incidence of Acute Coronary Syndrome the Egyptian population.
We found that common variants of the CX3CR1 gene influence amyotrophic lateral sclerosis survival. Our data provide further evidence for the role of neuroinflammation in amyotrophic lateral sclerosis
CX3CR1 genetic variants represent new modifying factors of pathology progression and age of onset in late-onset Alzheimer's disease.
Study demonstrated that CX3CL1/CX3CR1 was overexpressed in prostate cancer tissues with spinal metastasis compared with primary tumors. Overexpression of CX3CR1 increased cell proliferation, migration and invasion. Also, study observed that EGFR/Src/FAK pathway was activated by CX3CL1/CX3CR1.
CX3CR1 major allele carriers V249 and T280 are significantly associated with an increased total arterial blood volume of the whole brain, especially around the bilateral precuneus, left posterior cingulate cortex, and left posterior parietal cortex.
investigated the association of CX3CR1 839C/T, CX3CR1 745G/A, polymorphisms with Age-Related Macular Degeneration (AMD) risk. These associated with an increased AMD risk (CX3CR1 839C/T, additive model: aOR=2.682, 95% CI=1.119-5.709, P=0.022, recessive model: aOR=2.729, 95% CI=1.141-6.048, P=0.010; CX3CR1 745G/A, additive model: aOR=2.614, 95% CI=1.231-6.012, P=0.020, recessive model: aOR=2.340, 95% CI=1.227-5.993, P=0.011
CX3CR1 regulated chondrocyte proliferation.
We detected a statistically significant association between the variant Ala55Thr in CX3CR1 with schizophrenia and autism spectrum disorder phenotypes
This study shown that CX3CR1 expression in both Microglia and Astrocytes in hippocampus in affected by stroke, Alzheimer's disease, and Lewy body dementia.
The US28 gene product has maintained the function of the ancestral gene and has the ability to bind and signal in response to human CX3CL1, the natural ligand for CX3CR1.
Our findings demonstrate that motility, invasion, and contact-independent growth of PDAC cells all increase following CX3CL1 exposure, and that antagonism of CX3CR1 by the inhibitor JMS-17-2 reduces each of these phenotypes and correlates with a downregulation of AKT phosphorylation.
in Crohn's disease patients, a missense mutation in the gene encoding CX3CR1 was identified and found to be associated with impaired antifungal responses
These findings suggest an essential role of the CX3CR1/NRF2 axis in microglial function and in tauopathies. Therefore, polymorphisms with loss of function in CX3CR1 or NRF2 have to be taken into account for the development of therapeutic strategies.
In experimental autoimmune encephalomyelitis, OVA-specific T cells exacerbate outcome in Cnp-OVA mice but ameliorate EAE in Nes-OVA mice in a CX3CR1-dependent manner. Despite similar levels of peripheral antigen sampling, CNS antigen-specific T cells differentially influence neuroinflammatory disease depending on the location of cognate antigens and the presence of CX3CL1/CX3CR1 signaling.
Loss of the microglial Cx3cr1 signaling pathway resulted in specific alterations in the cilium, a key structure in photoreceptor outer segment elongation
CX3CR1 exerts protective properties by modulating the invasion of inflammatory cells in hypertensive renal injury.
Microglial repopulation was regulated by CX3CL1-CX3CR1 signaling.
lungs of CX3CR1-deficient mice expressed higher levels of IL-1beta mRNA and protein, and blockade of IL-1beta signaling using IL-1 receptor antagonist significantly reduced the number of IL-17+ gammadelta T cells in the lungs of infected mice
findings demonstrate that lactate and pyruvate, which are produced in the intestinal lumen in a bacteria-dependent manner, contribute to enhanced immune responses by inducing GPR31-mediated dendrite protrusion of intestinal CX3CR1(+) cells
The findings of this study suggested that impaired CX3CR1 function in the cochlea may worsen the degeneration of SGNs after hair cell injury and that macrophages appear to play a neuroprotective role in the damaged cochlea.
CX3CR1 might be an important regulator for MHC-II expressions on APCs, playing a beneficial role in EAE.
Preterm labor (PTL) was suppressed in Cx3cr1-/- mice and immunoneutralization of CX3CL1 in WT mice. From immunohistochemical and the gene expression analyses, the CX3CL1-CX3CR1 axis has detrimental roles in PTL through intrauterine recruitment of macrophages and the enhancement of macrophage-derived inflammatory mediators.
Authors observed that female CX3CR1-/- mice exhibit a hyperactive, anxiolytic-like and depressive-like phenotype. These data shed light on novel aspects of the regulation of adult hippocampal neurogenesis by microglia that could be highly relevant for research into mood disorders.
In the presence of the normal microbiota, intestinal antigen-presenting cells (APCs) expressing chemokine receptor CX3CR1 reduce expansion of intestinal microbe-specific T helper 1 (Th1) cells and promote generation of regulatory T cells responsive to food antigens and the microbiota. Disruption of the microbiota results in CX3CR1(+) APC-dependent inflammatory Th1 cell responses with increased pathology after infection.
CXCR1 mediates neuronal apoptotic cell death in ischemia.
These data implicate sex differences in microglial activation in the modulation of energy homeostasis and identify CX3CR1 signalling as a potential therapeutic target for the treatment of obesity.
Using the Theiler's virus model of encephalitis in C57BL/6 mice study shows that CCR2 as well as CX3CR1 plays a key role in the accumulation of myeloid cells in the CNS and activation of hippocampal myeloid cells upon infection.
Ang II up-regulates CX3CR1 expression in VSMCs via NADPH oxidase/ROS/p38 MAPK pathway and the CX3CL1/CX3CR1 axis contributes to the proliferative and pro-inflammatory effects of Ang II in VSMCs.
CX3CR1 ablation enhanced the neurotrophic action of microglia in Mecp2KO mice
These findings indicate that emotional and cognitive stress resilience involves CX3CR1-dependent basal and stress-induced alterations in hippocampal transcription
The effect of CX3CR1 deletion on murine acetabular development provides suggestive evidence of a susceptibility inducing role of the CX3CR1 gene on developmental dysplasia of the hip.
Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene.
, CX3C chemokine receptor 1
, G protein-coupled receptor 13
, G-protein coupled receptor 13
, beta chemokine receptor-like 1
, chemokine (C-C) receptor-like 1
, chemokine (C-X3-C) receptor 1
, fractalkine receptor
, CX3C chemokine receptor 1-like
, Fractalkine receptor
, chemokine receptor 1
, chemokine (C-X3-C motif) receptor 1