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anti-Mouse (Murine) DEFa3 Anticorps:
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results indicate that alpha-defensin 1 (Montrer DEFA1 Anticorps), 2, and 3 collectively account for much of the anti-HIV-1 activity of CD8 (Montrer CD8A Anticorps) antiviral factor (CAF (Montrer KAT2B Anticorps)) that is not attributable to beta-chemokines
these results demonstrate that HNPs1-3 may be potent inhibitors of ADAMTS13 (Montrer ADAMTS13 Anticorps) activity, likely by binding to the central A2 domain of VWF (Montrer VWF Anticorps) and physically blocking ADAMTS13 (Montrer ADAMTS13 Anticorps) binding.
we found that DEFA1A3 is expressed in renal epithelium and not restricted to myeloid-derived cells, such as neutrophils. In conclusion, low DEFA1A3 copy number associated with recurrent urinary tract infections in subjects in the RIVUR Study randomized to prophylactic antibiotics, providing evidence that copy number polymorphisms in an antimicrobial peptide (Montrer cAMP Anticorps) associate with urinary tract infection risk
High HNP3 expression is associated with IgA Nephropathy.
RTD-1 reduced the secretion of tumor necrosis factor-alpha (TNF-alpha (Montrer TNF Anticorps)), interleukin (IL)-1beta (Montrer IL1B Anticorps), and IL-8 (Montrer IL8 Anticorps) in lipopolysaccharide (LPS (Montrer IRF6 Anticorps))-stimulated human blood monocytes and THP-1 (Montrer GLI2 Anticorps) macrophages
Elevated DEFA3 levels in diabetes are independent of DEFA3 copy numbers.
DEFA3 encodes an antibacterial peptide that is bacteriocidal against S. aureus, E. coli, and P. aeruginosa.
A decrease in salivary HNP 1 (Montrer DEFA1 Anticorps)-3 levels might be a biological factor for predisposition to oral ulcers in patients with Behcet disease and oral infection in healthy patients.
Results indicate that the gene expression of DEFA 1 (Montrer DEFA1 Anticorps)/3 and 4 was significantly increased in all tumours - except for a significant decrease of DEFA 4 (Montrer DEFA4 Anticorps) gene expression in pleomorphic adenomas.
DEFA1A3 copy numbers did not differ significantly between systemic lupus erythematosus patients and controls. DEFA1A3 copy numbers ranged from 3 to 11 in Han Chinese in Beijing and 4 to 16 in Japanese in Tokyo.
MMP-7 (Montrer MMP7 Anticorps)-dependent procryptdin activation in vivo provides mouse Paneth cells with functional peptides for apical secretion into the small intestine lumen
cryptdin 3 forms anion-selective channels on the cytoplasmic membrane of HEK (Montrer EPHA3 Anticorps) cells and that the kinetics of one such channel are affected by its interaction with other such channels.
Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.
neutrophil defensin 3
, Paneth cell-specific alpha-defensin 3
, alpha-defensin 3, neutrophil-specific
, alpha-defensin 3
, defensin, alpha, 27
, defensin-related cryptdin-3
, defensin 3, neutrophil-specific
, neutrophil peptide 3