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anti-Human Fibronectin Anticorps:
anti-Mouse (Murine) Fibronectin Anticorps:
anti-Rat (Rattus) Fibronectin Anticorps:
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Chicken Monoclonal Fibronectin Primary Antibody pour ICC, IHC (fro) - ABIN3043242
Zhang, Chen, Qi, Wang, Xiao, Zhu: Inhibition of calcium-calmodulin-dependent kinase II suppresses cardiac fibroblast proliferation and extracellular matrix secretion. dans Journal of cardiovascular pharmacology 2010
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Human Monoclonal Fibronectin Primary Antibody pour FACS, ELISA - ABIN969520
Ryschich, Khamidjanov, Kerkadze, Büchler, Zöller, Schmidt: Promotion of tumor cell migration by extracellular matrix proteins in human pancreatic cancer. dans Pancreas 2009
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Human Monoclonal Fibronectin Primary Antibody pour FACS, IHC - ABIN969149
Huang, Zhang, Kim, Ge, Annis, Mosher, Greenspan: Fibronectin binds and enhances the activity of bone morphogenetic protein 1. dans The Journal of biological chemistry 2009
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Human Monoclonal Fibronectin Primary Antibody pour FACS - ABIN4898545
Purushothaman, Bandari, Liu, Mobley, Brown, Sanderson: Fibronectin on the Surface of Myeloma Cell-derived Exosomes Mediates Exosome-Cell Interactions. dans The Journal of biological chemistry 2016
Injection of alpha5beta1 protein rescued the Fibronectin layer and then the myocardial precursor migration in snai1b knockdown embryos.
Fibronectin, a main component of the extracellular matrix, is induced and deposited after cardiac damage
Fibronectin deficiency resulted in a dramatic reduction of mesoderm accompanied by endodermal expansion in zebrafish embryos.
Data indicate that focal adhesion kinase (FAK) activity may be a mediator of the integrin alpha5/Fn1 interaction during zebrafish lens fiber morphogenesis.
reduction of fn1 function enables rescue of cardiac fusion in hand2 (Montrer HAND2 Anticorps) mutants
Fibronectin regulates epithelial organization during myocardial migration in zebrafish.
EGF (Montrer EGF Anticorps) and TNFalpha (Montrer TNF Anticorps) cooperatively promoted the motility of HCC (Montrer FAM126A Anticorps) cells mainly through NF-kappaB (Montrer NFKB1 Anticorps)/p65 (Montrer GORASP1 Anticorps) mediated synergistic induction of FN in vitro. These findings highlight the crosstalk between EGF (Montrer EGF Anticorps) and TNFalpha (Montrer TNF Anticorps) in promoting HCC (Montrer FAM126A Anticorps), and provide potential targets for HCC (Montrer FAM126A Anticorps) prevention and treatment.
RT-PCR together with Sanger sequencing verified the presence of the FN1-ALK (Montrer ALK Anticorps) fusion transcripts
Fibronectin is readily modified by ONOOH at low (physiologically-relevant) molar ratios of oxidant to protein.
The 45 kDa gelatin-binding domain of fibronectin is responsible for the binding to TGM2 (Montrer TGM2 Anticorps).
Proteomics study showed a strong association of FN1, A2M (Montrer A2M Anticorps), C4BPA (Montrer C4BPA Anticorps) and CFB (Montrer CFB Anticorps) in molecular subtypes of breast cancer. The findings also revealed the altered level expressions of these selected proteins could classify BC subtypes through plasma and tissue based expression analysis
FN1/CCL2 (Montrer CCL2 Anticorps) levels are elevated in the bronchoalveolar lavage fluid from pulmonary sarcoidosis patients.
Cancer-associated fibroblasts organize the fibronectin matrix and promote directional prostate cancer cell migration.
FN1 mutations that cause defective fibronectin secretion are found in SMD.
FN1 overexpression is an important determinant of thyroid cancer aggressiveness.
Thyroid hormone (Montrer PTH Anticorps) T3 induces fibronectin and HIF-1alpha (Montrer HIF1A Anticorps) synthesis via PI3K (Montrer PIK3CA Anticorps)/AKT (Montrer AKT1 Anticorps) signaling pathway.
Factor XIII (Montrer UGDH Anticorps)-A and TG2 (Montrer TGM2 Anticorps) regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow.
we disclosed the role of chemotaxis and apoptosis in the fibrotic microenvironment-enhanced seeding of tumor cells and identified the fibroblast-derived FN1 and SPP1 (Montrer SPP1 Anticorps) as the central mediators in these processes
PD increased CKIP-1 and Nrf2 (Montrer NFE2L2 Anticorps) levels in the kidney tissues as well as improved the anti-oxidative effect and renal dysfunction of diabetic mice, which eventually reversed the up-regulation of FN and ICAM-1 (Montrer ICAM1 Anticorps)
Histone methyltransferase Suv39h1 (Montrer SUV39H1 Anticorps) attenuates high glucose-induced fibronectin and p21(WAF1 (Montrer CDKN1A Anticorps)) in mesangial cells
fibronectin has a critical role in tissue morphogenesis and the development of tissue heterogeneities
The aged stem cell niche in skeletal muscle contains reduced levels of FN, leading to detrimental consequences for the function and maintenance of muscle stem cells (MuSCs). FN is a preferred adhesion substrate for MuSCs and integrin-mediated signaling via focal adhesion kinase and the p38 MAPK (Montrer MAPK14 Anticorps) pathway is strongly de-regulated in MuSCs from aged mice because of insufficient attachment to the niche.
analysis of novel functions for two fibronectin isoforms and the mediating receptors in osteoblast differentiation
scleraxis (Montrer SCX Anticorps) was required for TGFbeta (Montrer TGFB1 Anticorps)-induced fibronectin expression: TGFbeta (Montrer TGFB1 Anticorps) lost its ability to induce fibronectin expression following scleraxis (Montrer SCX Anticorps) knockdown.
The results very comprehensively demonstrate distinct signaling pathways that regulate microfilament organization, lamellipodial structures, spreading, and movement of cells plated on galectin-3 (Montrer LGALS3 Anticorps) as opposed to fibronectin.
Thus, similarly to growth factor signaling, fibronectin matrix assembly during early development can be both autocrine and paracrine.
plasma FN assembly into bone matrix in vitro requires FXIIIA transglutaminase activity making pFN assembly an active, osteoblast-mediated process.
Fetal and adult human skin fibroblasts retain their differential proliferative response to TGF-beta (Montrer TGFB1 Anticorps) when cultured in the presence of fibronectin and unpolymerized or polymerized collagen.
Putative function of fibronectin and its receptor (integrin alpha(5 (Montrer ITGA5 Anticorps))beta(1)) in male and female gametes during bovine fertilization in vitro.
These results highlight a crucial role for caveolin-1 (Montrer CAV1 Anticorps) in negative regulation of membrane microdomain mobility, thereby affecting endocytosis of bacteria-engaged integrins.
P. multocida-Fn interaction may play a role in the bacterium adherence to host cells, and this may be mediated by bacterial surface proteins with preferential affinity for the Hep-1 binding domain of Fn
The expression of extracellular matrix molecules fibronectin and osteopontin (Montrer SPP1 Anticorps) in vitreous and retina samples in autoimmune uveitis was investigated.
The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process.
The relationship between hyaluronan synthesis and levels of versican (Montrer Vcan Anticorps), fibronectin and several other extracellular matrix components in trabecular meshwork cells from the anterior segment of the eye was investigated.
fibronectin has a cryptic binding site for tenascin (Montrer TNC Anticorps)
Transplantation experiments demonstrate a tissue-autonomous role for DS epimerase (Montrer DSE Anticorps)-1 in cranial neural crest (NC) cell migration in vivo Cranial NC explant and single-cell cultures indicate a requirement of DS epimerase (Montrer DSE Anticorps)-1 in cell adhesion, spreading and extension of polarized cell processes on fibronectin.
This gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Fibronectin is involved in cell adhesion and migration processes including embryogenesis, wound healing, blood coagulation, host defense, and metastasis. The gene has three regions subject to alternative splicing, with the potential to produce 20 different transcript variants. However, the full-length nature of some variants has not been determined.
, gene C
, cold-insoluble globulin
, migration-stimulating factor
, cumulus cell-specific fibronectin 1 transcript
, embryo-specific fibronectin 1 transcript
, fibronectin ED-A- region
, fibronectin variable region