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anti-Human PAF1 Anticorps:
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Human Polyclonal PAF1 Primary Antibody pour WB - ABIN153212
Lin, Czapiga, Nini, Zhang, Simonds: Nuclear localization of the parafibromin tumor suppressor protein implicated in the hyperparathyroidism-jaw tumor syndrome enhances its proapoptotic function. dans Molecular cancer research : MCR 2007
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Human Polyclonal PAF1 Primary Antibody pour ICC, IF - ABIN153213
Chipumuro, Henriksen: The ubiquitin hydrolase USP22 contributes to 3'-end processing of JAK-STAT-inducible genes. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
These results reveal ubiquitin-proteasome system regulation of Paf1 (Montrer PEX2 Anticorps) and suggest downregulation of ubiquitin-proteasome system in elevating Paf1 (Montrer PEX2 Anticorps)'s abundance in poorly differentiated cancers.
High PAF1 (Montrer PEX2 Anticorps) expression is associated with ovarian cancer.
Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma.
Propose that degradation of MYC (Montrer MYC Anticorps) limits the accumulation of MYC (Montrer MYC Anticorps)/PAF1C complexes during transcriptional activation.
Mechanistic studies indicated that PAF1C could promote lung cancer cell proliferation through regulating c-MYC (Montrer MYC Anticorps) transcription.
CNOT4 (Montrer CNOT4 Anticorps) controls the degradation of chromatin-unbound PAF1 (Montrer PEX2 Anticorps) via the 26S proteasome (Montrer Psmd4 Anticorps).
this study found that Pol II-associated factor 1 (PAF1 (Montrer PEX2 Anticorps)) is a critical regulator of paused Pol II release, that positive transcription elongation factor b (P-TEFb (Montrer CDK9 Anticorps)) directly regulates the initial recruitment of PAF1 (Montrer PEX2 Anticorps) complex (PAF1C) to genes, and that the subsequent recruitment of CDK12 (Montrer CRKRS Anticorps) is dependent on PAF1C.
This study reveals an evolutionarily conserved role for PAF1 (Montrer PEX2 Anticorps) as a regulator of promoter-proximal pausing by RNA Pol II in all metazoans, including human.
PD2 is a novel cancer stem cell (CSC) maintenance protein, loss of which renders the CSCs more susceptible to drug-induced cell death.
Together, these results indicate that human adenovirus E1A (Montrer BCKDHA Anticorps) uses hBre1 (Montrer RNF20 Anticorps) to recruit the hPaf1 complex in order to optimally activate viral early transcription by enhancing transcriptional elongation.
link Paf1C with PolII elongation and RNA processing indicates that Paf1C subunits could play roles in controlling transcript length through suppression of PolII accumulation at transcription start site (TSS (Montrer RPL38 Anticorps))-proximal pA sites
The PAF1 (Montrer PEX2 Anticorps) complex is required for mammalian development, likely through regulation of H3K36me3, indicating a functional conservation of the PAF1 (Montrer PEX2 Anticorps) complex from yeast to mammals in vivo.
As part of a cell-intrinsic transcriptional pathway, Paf1 (Montrer PEX2 Anticorps) regulates neuronal migration in the brain.
MLL (Montrer MLL Anticorps) interacts directly with the polymerase associated factor complex (PAFc) via Paf1 (Montrer PEX2 Anticorps) and CTR9 (Montrer CTR9 Anticorps). PAFc augments MLL (Montrer MLL Anticorps) and MLL (Montrer MLL Anticorps)-AF9 (Montrer MLLT3 Anticorps) mediated transcriptional activation of Hoxa9 (Montrer HOXA9 Anticorps) and their interaction is essential for leukemogenesis.
show that Paf1/PD2 is overexpressed in mouse embryonic stem cells (ESCs (Montrer NR2E3 Anticorps)) and is involved in the maintenance of mouse ESCs (Montrer NR2E3 Anticorps).
The PAF1 complex differentially regulates cardiomyocyte specification.
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
RNA polymerase II-associated factor 1 homolog
, pancreatic differentiation protein 2
, PD2-like protein
, paf1, RNA polymerase II associated factor, homolog, like
, Paf1, RNA polymerase II associated factor, homolog