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Human Polyclonal PDE4D Primary Antibody pour CM, ICC - ABIN2747152
Farooqui, Al-Bagdadi, Houslay, Bolger, Stout, Specian, Cherry, Conti, ODonnell: Surgically induced cryptorchidism-related degenerative changes in spermatogonia are associated with loss of cyclic adenosine monophosphate-dependent phosphodiesterases type 4 in abdominal testes of rats. dans Biology of reproduction 2001
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Human Polyclonal PDE4D Primary Antibody pour ELISA, WB - ABIN185530
Houslay: The long and short of vascular smooth muscle phosphodiesterase-4 as a putative therapeutic target. dans Molecular pharmacology 2005
Show all 3 Pubmed References
These results indicate that Phosphodiesterase-4D overexpression may be involved in the development of surgery-induced cognitive dysfunction in mice.
The effect of dobutamine as a positive inotrope is impaired in mice with cecal ligation and puncture-induced sepsis without changes in cardiac beta1-adrenoceptor signaling as a result of cAMP breakdown achieved by upregulated phosphodiesterase 4D
In vivo knockdown of (Montrer FN1 Anticorps) PDE4D5 inhibited inflammation at athero-prone sites (Montrer TWIST1 Anticorps)
Results indicate that the cyclic AMP (Montrer TMPRSS5 Anticorps) (cAMP) increase is caused by the attenuation of phosphodiesterase (PDE (Montrer TWIST1 Anticorps)) activity adrenal cortex-derived Y-1 cell line.
The authors demonstrate that the Attention Deficit Disorder with Hyperactivity phenotype depends on a dysregulation of CREB (Montrer CREB1 Anticorps) signaling exerted by a kinase-independent PI3Kgamma (Montrer PIK3CG Anticorps)-PDE4D interaction in the noradrenergic neurons of the locus coeruleus.
SIK1 (Montrer SIK1 Anticorps) serves as a part of a self-regulatory circuit to modulate insulin (Montrer INS Anticorps) secretion from pancreatic beta-cells by controlling cAMP concentration through modulation of PDE4D activity.
Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle, contributing to colonic dysmotility during inflammation.
the loss of function of either DISC1 (Montrer DISC1 Anticorps) or ATF4 (Montrer ATF4 Anticorps) increases PDE4D9 transcription, and the association of DISC1 (Montrer DISC1 Anticorps) with the PDE4D9 locus requires ATF4 (Montrer ATF4 Anticorps)
these results suggest that Pde4d might serve specific biological functions in regulating the development process of the mouse embryo, and that CpG methylation of the Pde4d promoter may play an important role in regulating Pde4d at a transcriptional level.
Calcineurin regulates degradation of phosphodiesterase 3B (Montrer PDE3B Anticorps), in addition to phosphodiesterase 4D.
SNP 83 of PDE4D gene may increase the risk for developing ischemic stroke whereas SNP 87 and SNP45 of PDE4D may not be associated with the risk of ischemic stroke in the North Indian population
Results provide new information concerning the mechanism whereby the mutations identified in the ACRDYS2 dysregulate PDE4D activity, and give insights into rare diseases involving the cAMP signaling pathway.
This supports PDE4D5 and RACK1 as potential regulators of cell adhesion, spreading and migration through the non-classical exchange protein activated by cyclic AMP (EPAC1)/Rap1 signalling route
PDE4D isoform composition is altered in localized prostate cancer and it can be used both as a diagnostic as well as a prognostic biomarker.
Genetic analysis identified the identical, novel heterozygous missense mutation of the PDE4D gene c.569C>T (p.Ser190Phe) in two patients in same family. This case illustrates the significant phenotypic variability of acrodysostosis even within one family with identical mutations.
Screening of PRKAR1A (Montrer PRKAR1A Anticorps) and PDE4D in a Large Italian Series of Patients Clinically Diagnosed With Albright Hereditary Osteodystrophy and/or Pseudohypoparathyroidism
p53 (Montrer TP53 Anticorps) induced the transcription of miR (Montrer MLXIP Anticorps)-139-5p, which in turn suppressed the protein levels of phosphodiesterase 4D (PDE4D), an oncogenic protein involved in multiple tumor promoting processes.
High PDE4D expression is associated with melanoma.
cells on fibronectin (Montrer FN1 Anticorps) suppressed cAMP via enhanced phosphodiesterase (PDE (Montrer ALDH7A1 Anticorps)) activity, through direct binding of integrin alpha5 to phosphodiesterase-4D5
we performed a meta-analysis of 15 studies, involving 8731 IS patients and 10,756 controls. The results showed nonsignificant association between PDE4D SNP56 and IS risk (T vs. A: OR=1.01, 95%CI=0.88-1.15, P=0.90). Similarly, in the subgroup analysis by ethnicity, no significant association was observed in Asian (T vs. A: OR=1.08, 95%CI=0.80-1.44, P=0.62) or European (T vs. A: OR=0.96, 95%CI=0.86-1.08, P=0.54) population.
demonstrate the presence of PDE4D transcript and protein, but also show an active enzyme, suggesting a functional role of PDE4D in bovine mammary gland
This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.
phosphodiesterase E3 dunce homolog, Drosophila
, phosphodiesterase 4D, cAMP-specific
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D-like
, phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
, cAMP-specific 3',5'-cyclic phosphodiesterase 4D
, cAMP-specific phosphodiesterase 4D
, cyclic AMP specific phosphodiesterase PDE4D5A
, cAMP-specific phosphodiesterase PDE4D6
, Phosphodiesterase 4D cAMP-specific (dunce
, Phosphodiesterase 4D, cAMP-specific (dunce
, cAMP-specific phosphodiesterase PDE4D
, cAMP-specific phosphodiesterase splice variant PDE4D8
, phosphodiesterase 4D, cAMP specific
, hypothetical protein