anti-Chien AIRE anticorps pour Enzyme Immunoassay

Recommended AIRE Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Autoimmune Regulator (AIRE) Anticorps
  • AIRE1
  • APECED
  • APS1
  • APSI
  • PGA1
  • autoimmune regulator
  • autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
  • AaeL_AAEL013794
  • CpipJ_CPIJ001208
  • CpipJ_CPIJ001209
  • AIRE
  • Aire
Épitope
Internal Region, Isoform 1
36
18
17
15
10
10
5
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivité
Chien, Humain, Rat (Rattus)
147
71
29
10
9
8
5
4
4
2
1
Hôte
Chèvre
97
56
18
1
Clonalité
Polyclonal
Conjugué
Cet anticorp AIRE est non-conjugé
8
6
5
5
5
5
2
2
2
2
2
2
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
146
85
40
35
18
18
13
6
5
4
2
1
1
1
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N° du produit ABIN5553212
$ 455.40
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN372242 EIA IHC (p) WB Goat IgG Internal Region Connectez-vous pour afficher Polyclonal 0

General

Antigène Autoimmune Regulator (AIRE) Anticorps
Épitope Internal Region, Isoform 1
(36), (18), (17), (15), (10), (10), (5), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Chien, Humain, Rat (Rattus)
(147), (71), (29), (10), (9), (8), (5), (4), (4), (2), (1)
Hôte Chèvre
(97), (56), (18), (1)
Clonalité
Polyclonal
Conjugué Cet anticorp AIRE est non-conjugé
(8), (6), (5), (5), (5), (5), (2), (2), (2), (2), (2), (2), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(146), (85), (40), (35), (18), (18), (13), (6), (5), (4), (2), (1), (1), (1)
Fournisseur Connectez-vous pour afficher

Détail du produit anti-AIRE anticorps

Détail du antigène AIRE Information d'application Stockage Images
Séquence C-KDVDLSQPRK GRKP
Specificité This antibody is expected to recognise isoform 1 (NP_000374.1) only.
Réactivité croisée (Details) Species reactivity (expected):Rat, Canine and Cow.
Species reactivity (tested):Human.
Purification Ammonium sulphate precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Immunogène Peptide with sequence from the internal region of the protein sequence according to NP_000374.1.

Détail du antigène AIRE

Détail du produit anti-AIRE anticorps Information d'application Stockage Images Haut de la page
Antigène
Autre désignation AIRE / APECED (AIRE Antibody Extrait)
Sujet AIRE is a transcriptional regulator that is thought to be important in controlling tissue-specific expression of genes in the thymus. The precise function of the protein is not well defined. It contains zinc finger motifs and isoform 1 is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described. The longer AIRE1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE3 includes the same exon 1-8-9 sequences as found in AIRE2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized. The resulting protein products of these splice variants differ significantly. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).Synonyms: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, Autoimmune regulator
ID gène 326, 9606
UniProt O43918
Pathways Chromatin Binding

Information d'application

Détail du produit anti-AIRE anticorps Détail du antigène AIRE Stockage Images Haut de la page
Indications d'application Peptide ELISA: 1/32000. Western blot: 0.5-1.0 μg/mL. Immunohistochemistry: 2.5 μg/mL. In paraffin embedded Human Thymus shows nuclear staining in select thymocytes.
Restrictions For Research Use only

Stockage

Détail du produit anti-AIRE anticorps Détail du antigène AIRE Information d'application Images Haut de la page
Concentration 0.5 mg/mL
Buffer Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freezing and thawing.
Stock 4 °C/-20 °C
Stockage commentaire Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.