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Human Polyclonal CENPA Primary Antibody pour DB, ICC - ABIN2668362
Logsdon, Barrey, Bassett, DeNizio, Guo, Panchenko, Dawicki-McKenna, Heun, Black: Both tails and the centromere targeting domain of CENP-A are required for centromere establishment. dans The Journal of cell biology 2015
H4K5ac and H4K12ac, mediated by RbAp46 (Montrer RBBP7 Anticorps)/48, facilitates efficient CENP-A deposition into centromeres.
Collectively, these studies clarify how CENP-N (Montrer CENPN Anticorps) and CENP-C (Montrer CENPC1 Anticorps) decode and stabilize the non-canonical CENP-A nucleosome to enforce epigenetic centromere specification and kinetochore assembly.
the SGT1 (Montrer SUGT1 Anticorps)-HSP90 (Montrer HSP90 Anticorps) complex contributes to the E3 ligase activity of the CUL4A (Montrer CUL4A Anticorps) complex that is necessary for CENP-A ubiquitylation and CENP-A deposition at the centromere.
during the CENP-A/H4 deposition process, the chaperone HJURP (Montrer HJURP Anticorps) protects various substructures of the dimer, serving both as a folding and binding chaperone
This study provides insights into how overexpression of CENP-A may contribute to CIN (Montrer PDXP Anticorps) in cancers and underscore the importance of understanding the pathways that prevent CENP-A mislocalization for genome stability.
Findings indicate the role of the amino-terminus of centromere protein A (CENP-A) in localization.
Levels of centromere aberrations increase upon depletion of CENP-A, CENP-C (Montrer CENPC1 Anticorps), and CENP-T (Montrer CENPT Anticorps)/W, during replicative senescence, and in cancer cells.
findings demonstrate the involvement of consensus Cdk1 (Montrer CDK1 Anticorps) phosphorylation sites on Mis18 complex assembly and thus provide a rationale for cell cycle-regulated timing of Mis18 assembly and CENP-A deposition
Upon cross-linking, the entire CENPA/CENPB (Montrer CENPB Anticorps)/CENPC (Montrer CENPC1 Anticorps)/CENPT (Montrer CENPT Anticorps) complex is nuclease (Montrer DCLRE1C Anticorps)-protected over an alpha-satellite dimer that comprises the fundamental unit of centromeric chromatin. We conclude that CENPA/CENPC and CENPT (Montrer CENPT Anticorps) pathways for kinetochore assembly are physically integrated over young alpha-satellite dimers.
we review our current understanding of CENP-A evolution in relation to centromere drive and discuss classical and recent advances, including new evidence implicating CENP-A chaperones in this conflict.
Centromeres with more satellite repeats house more nucleosomes that confer centromere identity, containing the histone H3 (Montrer HIST3H3 Anticorps) variant CENP-A, and bias their segregation to the egg relative to centromeres with fewer repeats.
The findings provide evidence that CENP-A is critical for the faithful chromosome segregation during mammalian oocyte meiosis.
evolutionarily conserved flexible ends of the CENP-A nucleosomes are essential to ensure the fidelity of the mitotic pathway.
These data implicate the insulin (Montrer INS Anticorps)-FoxM1 (Montrer FOXM1 Anticorps)/PLK1/CENP-A pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
CPCs maintain relatively high levels of CENP-A early in life, which is necessary for sustaining proliferation, inhibiting senescence, and promoting survival following differentiation of CPCs.
Results report that the level of CENP-A, a protein required for cell division, declines precipitously with age in an islet-specific manner.
Cenpa, Cenpb (Montrer CENPB Anticorps), and Bub3 (Montrer BUB3 Anticorps), but not Cenpc (Montrer CENPC1 Anticorps), interacted with PARP-1 (Montrer PARP1 Anticorps)
The centromere-targeting domain of CENP-A is both necessary and sufficient for recruitment to double-strand breaks. CENP-A accumulation at DNA breaks is enhanced by active non-homologous end-joining but does not require DNA-PKcs (Montrer PRKDC Anticorps) or Ligase IV.
CENP-C (Montrer CENPC1 Anticorps) and M18BP1 (Montrer MIS18BP1 Anticorps) recruit HJURP (Montrer HJURP Anticorps) to centromeres for new CENP-A assembly.
CENP-A assembly into chromatin requires unidentified deoxycytidine deaminase (Montrer APOBEC3G Anticorps) and UNG2 (Montrer CCNO Anticorps), a uracil DNA glycosylase (Montrer UNG Anticorps).
CENP-A deposition at the centromeres is dependent on HJURP (Montrer HJURP Anticorps).
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
centromere autoantigen A
, centromere protein A, 17kDa
, centromere-specific histone
, histone H3-like centromeric protein A
, centrosomin A
, centromere protein, Xenopus
, centromeric histone-3 like protein
, centromere protein A