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anti-Human MEIS1 Anticorps:
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Human Polyclonal MEIS1 Primary Antibody pour ELISA, WB - ABIN451639
Wong, Iwasaki, Somervaille, So, So, Cleary: Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. dans Genes & development 2007
Human Polyclonal MEIS1 Primary Antibody pour ELISA, WB - ABIN561793
Xiong, Catoire, Dion, Gaspar, Lafrenière, Girard, Levchenko, Rivière, Fiori, St-Onge, Bachand, Thibodeau, Allen, Earley, Turecki, Montplaisir, Rouleau: MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. dans Human molecular genetics 2009
By investigating the role of MEIS1 in ccRCC cells' survival, proliferation, anchorage-independent growth, cell cycle progress, apoptosis and metastasis, in the present work, we propose that MEIS1 may play an important role in clear cell renal cell carcinoma (Montrer MOK Anticorps) (ccRCC) development.
Conclusions MEIS1 variants were associated with an increased risk of RLS in migraine patients. It is possible that an imbalance in iron homeostasis and the dopaminergic system may represent a link between RLS incidence and migraines.
We speculate that ACTR2 and MEIS1 might respectively play a role in the pathogenesis of the observed deafness and cardiomyopathy...the patient carrying a 2p14p15 deletion including OTX1 had normal kidneys and genitalia, thus confirming that OTX1 haploinsufficiency is not invariably associated with genitourinary defects.
results reveal that MEIS1, through induction of SYTL1 (Montrer SYTL1 Anticorps), promotes leukemogenesis and supports leukemic cell homing and engraftment, facilitating interactions between leukemic cells and bone marrow stroma.
Meis1 regulates expression and activation of Syk (Montrer SYK Anticorps) in Hoxa9 (Montrer HOXA9 Anticorps)-driven leukemia.
Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 (Montrer MAGI1 Anticorps) and rs9810566 at 3q26.2 near TNIK (Montrer TNIK Anticorps)
Results show that Meis1 may have a positive feedback with Msi1 (Montrer MSI1 Anticorps) during the esophageal squamous cell carcinoma progression.
Meis1 functions as an important regulator during the progression of acute myeloid leukemia (Montrer BCL11A Anticorps).
MEIS1 drivesMalignant peripheral nerve sheath tumors cell growth via the transcription factor ID1 (Montrer ID1 Anticorps), thereby suppressing expression of the cell cycle inhibitor p27 (Montrer PAK2 Anticorps)(Kip (Montrer CIB1 Anticorps)) and maintaining cell survival.
it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3 (Montrer FOXP3 Anticorps), and ER inhibited gene expression by interacting with THRB (Montrer THRB Anticorps) and GRHL1 (Montrer GRHL1 Anticorps).
The Ubx cofactor, Homothorax (Hth), was co-enriched with Ubx near enhancers that require Hth, even though Ubx and Hth did not co-localize throughout the nucleus. Thus, microenvironments of high local transcription factor and cofactor concentrations could help low-affinity sites overcome their kinetic inefficiency.
Hth+Tsh-induced tissue overgrowth requires the BMP2 (Montrer BMP2 Anticorps) Dpp (Montrer TGFb Anticorps) and the abnormal hyperactivation of its pathway. Rather than using autocrine Dpp (Montrer TGFb Anticorps) expression, Hth+Tsh cells increase their avidity for Dpp (Montrer TGFb Anticorps), produced locally, by upregulating extracellular matrix components.
the satellite repeats get transcribed in wild type embryos and that this transcription depends on the presence of Hth, which binds to them as well as to the ribosomal DNA region.
The retinal determination gene Dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie (Montrer YAP1 Anticorps) complex
Hth functions together with its co-factor Extradenticle to repress the R8-specific factor Senseless in dorsal rim (Montrer RBBP8 Anticorps) area R8 cells, allowing expression of an ultraviolet-sensitive R7 Rhodopsin (Montrer RHO Anticorps).
Functional dissection of the splice variants of the Drosophila gene homothorax (hth
Data indicate that loss of Lethal giant larvae (Lgl) tumor suppressor in the wing primordium induced epithelial neoplasia in its Homothorax (Hth)-expressing proximal domain.
cooperative binding sites for En, with the homeodomain-containing Hox (Montrer MSH2 Anticorps) cofactors Extradenticle (Exd) and Homothorax (Hth) was localized, within two CRMs that drive similar expression patterns
Hox (Montrer MSH2 Anticorps) genes and homothorax are required for motoneuron survival.
In the flight muscles, exd and hth are genetically upstream of another muscle identity gene, salm, and are direct transcriptional regulators of the signature flight muscle structural gene, Actin88F.
Data indicate that MiR (Montrer MYLIP Anticorps)-144 regulates primitive hematopoiesis through repression of meis1 during embryogenesis.
Loss of meis1 is associated with impaired hematopoiesis as well as vascular development.
This study demonistrated that Meis1 plays an important role in establishing the retinotectal map and organizing the visual system in zebrafish.
The Hox (Montrer MSH2 Anticorps) cofactor Meis1 acts upstream of gata1 (Montrer GATA1 Anticorps) to regulate primitive hematopoiesis.
Results implicate meis1 as a positive cell cycle regulator in early retinal cells, and provide evidence of an evolutionary conserved function for Hth/Meis genes in the maintenance of the proliferative, multipotent cell state during early eye development.
These results implicate that meis1 is a novel regulator involved in endothelial cell development, presumably affecting the vegf (Montrer VEGFA Anticorps) signaling pathway.
Data show that Irx7 and Irx1b are required for the proper formation and specification of rhombomeres 1 to 4, and that Irx7 functionally interacts with Meis1.1 to activate the expression of anterior hindbrain markers, such as krox20 (Montrer EGR2 Anticorps).
the role of Meis1 in sensorimotor gating and in the dopaminergic systems modulating it, is reported.
Results show Meis1 Is expressed in normal and aberrant ducts, pancreatic intraepithelial neoplasia, and pancreatic ductal adenocarcinoma and that its expression increases cell migration in pancreatic cancer through transcriptional activation of Mcam (Montrer MCAM Anticorps).
the Hoxa9 (Montrer HOXA9 Anticorps)- and Meis1-associated upregulation of Flt3 (Montrer FLT3 Anticorps) is a passive event with regard to leukemia development in mice and with limited relevance to the AML (Montrer RUNX1 Anticorps) pathology.
We found that expression of Emx2 (Montrer EMX2 Anticorps) and Lhx2 (Montrer LHX2 Anticorps) initiated between neuronal progenitor and neuronal precursor stages. As far as the sensory neurons of the vomeronasal organ are concerned, Meis1 and Meis2 (Montrer MEIS2 Anticorps) were only expressed in the apical layer, together with Gnai2 (Montrer GNAI2 Anticorps), but not in the basal layer.
we show that simultaneous deletion of Meis1 and Meis2 (Montrer MEIS2 Anticorps) in presumptive lens ectoderm results in arrested lens development in the pre-placodal stage, and neither lens placode nor lens is formed. We found that in the presumptive lens ectoderm of Meis1/Meis2 (Montrer MEIS2 Anticorps) deficient embryos Pax6 (Montrer PAX6 Anticorps) expression is absent
Meis1 is a major regulator of sympathetic target-field innervation and Meis1 deficient sympathetic neurons die by apoptosis from early embryonic stages to perinatal stages.
PCBP2 (Montrer PCBP2 Anticorps) overexpression rescues the Meis1 effects of Akt (Montrer AKT1 Anticorps)-mTOR (Montrer FRAP1 Anticorps) pathway and hypertrophy of cardiomyocytes.
Data indicate roles of myeloid ecotropic viral integration site 1 protein (Meis1) in both megakaryopoiesis and erythropoiesis.
Tumorigenesis by Meis1 overexpression is accompanied by a change of DNA target-sequence specificity which allows binding to the AP-1 (Montrer JUN Anticorps) element.
Sequential binding of MEIS1 and NKX2-5 (Montrer NKX2-5 Anticorps) on the Popdc2 (Montrer POPDC2 Anticorps) gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis.
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.
Meis1, myeloid ecotropic viral integration site 1 homolog
, homeobox protein Meis1
, leukemogenic homolog protein
, XMeis1-2 protein
, Meis homeobox 1
, gene II
, homeobox protein Meis1-like
, myeloid ecotropic viral integration site 1
, myeloid ecotropic viral insertion site-1a protein