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Human Polyclonal MEIS1 Primary Antibody pour ELISA, WB - ABIN451639
Wong, Iwasaki, Somervaille, So, So, Cleary: Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. dans Genes & development 2007
Human Polyclonal MEIS1 Primary Antibody pour ELISA, WB - ABIN561793
Xiong, Catoire, Dion, Gaspar, Lafrenière, Girard, Levchenko, Rivière, Fiori, St-Onge, Bachand, Thibodeau, Allen, Earley, Turecki, Montplaisir, Rouleau: MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels. dans Human molecular genetics 2009
TAL1 mediates the function of MEIS1 in hemogenic endothelial progenitors specification. In addition, MEIS1 is vital for megakaryopoiesis and thrombopoiesis from hPSCs. Mechanistically, FLI1 acts as a downstream gene necessary for the function of MEIS1 during megakaryopoiesis
Our results showed that MEIS1 may have a negative role in regulation of MAML1expression during the esophageal squamous cell carcinoma progression.
By investigating the role of MEIS1 in ccRCC cells' survival, proliferation, anchorage-independent growth, cell cycle progress, apoptosis and metastasis, in the present work, we propose that MEIS1 may play an important role in clear cell renal cell carcinoma (ccRCC) development.
Conclusions MEIS1 variants were associated with an increased risk of RLS in migraine patients. It is possible that an imbalance in iron homeostasis and the dopaminergic system may represent a link between RLS incidence and migraines.
We speculate that ACTR2 and MEIS1 might respectively play a role in the pathogenesis of the observed deafness and cardiomyopathy...the patient carrying a 2p14p15 deletion including OTX1 had normal kidneys and genitalia, thus confirming that OTX1 haploinsufficiency is not invariably associated with genitourinary defects.
results reveal that MEIS1, through induction of SYTL1, promotes leukemogenesis and supports leukemic cell homing and engraftment, facilitating interactions between leukemic cells and bone marrow stroma.
Meis1 regulates expression and activation of Syk in Hoxa9-driven leukemia.
Here we present the result of a 4-stage genome-wide association study composed of 5,953 adolescent idiopathic scoliosis patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 , rs7633294 at 3p14.1 near MAGI1 and rs9810566 at 3q26.2 near TNIK
Results show that Meis1 may have a positive feedback with Msi1 during the esophageal squamous cell carcinoma progression.
Meis1 functions as an important regulator during the progression of acute myeloid leukemia.
MEIS1 drivesMalignant peripheral nerve sheath tumors cell growth via the transcription factor ID1, thereby suppressing expression of the cell cycle inhibitor p27(Kip) and maintaining cell survival.
it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3, and ER inhibited gene expression by interacting with THRB and GRHL1.
this is the first report on the MEIS1 gene in esophageal squamous cell carcinoma
Infant patients with acute lymphoblastic leukemia expressing low levels of MEIS1 had a superior outcome over patients expressing high levels of the protein.
Our findings confirm an association between the BTBD9, MEIS1, and MAP2K5/SKOR1 SNPs and periodic limb movements of sleep in an elderly cohort.
It was observed that RE-IIBP induces MEIS1-mediated apoptosis, which was dependent on H2BK120 ubiquitination by RNF20.
Studies implicate PBX3/MEIS1 interaction as a driver of cell transformation and leukemogenesis, and that this axis may play a critical role in the regulation of the core transcriptional programs activated in MLL-rearranged and HOX-overexpressing AML.
The NK AML patients with NPM1 mutations exhibited elevated HOXA4 methylation and expression levels of HOXA5 and MEIS1 compared with the NPM1 wildtype patients.
Pbx3 contributes to Hoxa9 leukemogenesis through stabilization of the Meis1 protein.
HOXA9 and MEIS1 overexpression are inversely correlated with relapse and overall survival, so the genes could become useful predictive markers of the clinical course of pediatric acute leukemias.
Rather than directly regulating cell cycle genes, hth and tsh control cell proliferation through an intermediary layer of nuclear receptors of the ecdysone/estrogen-signaling pathway.
The Ubx cofactor, Homothorax (Hth), was co-enriched with Ubx near enhancers that require Hth, even though Ubx and Hth did not co-localize throughout the nucleus. Thus, microenvironments of high local transcription factor and cofactor concentrations could help low-affinity sites overcome their kinetic inefficiency.
Hth+Tsh-induced tissue overgrowth requires the BMP2 Dpp and the abnormal hyperactivation of its pathway. Rather than using autocrine Dpp expression, Hth+Tsh cells increase their avidity for Dpp, produced locally, by upregulating extracellular matrix components.
the satellite repeats get transcribed in wild type embryos and that this transcription depends on the presence of Hth, which binds to them as well as to the ribosomal DNA region.
The retinal determination gene Dachshund restricts cell proliferation by limiting the activity of the Homothorax-Yorkie complex
Hth functions together with its co-factor Extradenticle to repress the R8-specific factor Senseless in dorsal rim area R8 cells, allowing expression of an ultraviolet-sensitive R7 Rhodopsin.
Functional dissection of the splice variants of the Drosophila gene homothorax (hth
Data indicate that loss of Lethal giant larvae (Lgl) tumor suppressor in the wing primordium induced epithelial neoplasia in its Homothorax (Hth)-expressing proximal domain.
cooperative binding sites for En, with the homeodomain-containing Hox cofactors Extradenticle (Exd) and Homothorax (Hth) was localized, within two CRMs that drive similar expression patterns
Hox genes and homothorax are required for motoneuron survival.
In the flight muscles, exd and hth are genetically upstream of another muscle identity gene, salm, and are direct transcriptional regulators of the signature flight muscle structural gene, Actin88F.
Loss of Ct and Hth in the antenna disc resulted in ectopic eye development in the antenna.
Data suggest that optimum levels of L and Hth are required to define the boundary between the developing eye and head cuticle on the ventral margin.
These results support a critical role for Yki- and its partners Sd and Hth--in shaping the fate map of the eye epithelium.
Homothorax and extradenticle control dendritic and axonal targeting of olfactory projection neurons in the Drosophila brain.
whole genome ChIP-chip studies to identify all of the Ubx bound regions in the haltere and T3 leg imaginal discs and the sites bound by the Hox cofactor
genome-wide analysis of the binding sites for the Hox cofactor Homothorax and the Hox protein Ultrabithorax
Regulation of ocellar specification and size by twin of eyeless and homothorax.
This work suggests that the transcriptional activity of all members of the Meis/Prep Hth protein family is subject to autoinhibition by their Hth domains, and that the Meis3.2 splice variant encodes a protein that bypasses this autoinhibitory effect.
experiments reveal three additional functions for hth: the cell cycle of progenitors is characterized by a relatively long G2 phase, which makes them prone to enter mitosis; hth represses the burst of string/cdc25 expression that precedes G1 arrest
Data indicate that MiR-144 regulates primitive hematopoiesis through repression of meis1 during embryogenesis.
Loss of meis1 is associated with impaired hematopoiesis as well as vascular development.
This study demonistrated that Meis1 plays an important role in establishing the retinotectal map and organizing the visual system in zebrafish.
The Hox cofactor Meis1 acts upstream of gata1 to regulate primitive hematopoiesis.
Results implicate meis1 as a positive cell cycle regulator in early retinal cells, and provide evidence of an evolutionary conserved function for Hth/Meis genes in the maintenance of the proliferative, multipotent cell state during early eye development.
These results implicate that meis1 is a novel regulator involved in endothelial cell development, presumably affecting the vegf signaling pathway.
Data show that Irx7 and Irx1b are required for the proper formation and specification of rhombomeres 1 to 4, and that Irx7 functionally interacts with Meis1.1 to activate the expression of anterior hindbrain markers, such as krox20.
the role of Meis1 in sensorimotor gating and in the dopaminergic systems modulating it, is reported.
Results show Meis1 Is expressed in normal and aberrant ducts, pancreatic intraepithelial neoplasia, and pancreatic ductal adenocarcinoma and that its expression increases cell migration in pancreatic cancer through transcriptional activation of Mcam.
the Hoxa9- and Meis1-associated upregulation of Flt3 is a passive event with regard to leukemia development in mice and with limited relevance to the AML pathology.
We found that expression of Emx2 and Lhx2 initiated between neuronal progenitor and neuronal precursor stages. As far as the sensory neurons of the vomeronasal organ are concerned, Meis1 and Meis2 were only expressed in the apical layer, together with Gnai2, but not in the basal layer.
we show that simultaneous deletion of Meis1 and Meis2 in presumptive lens ectoderm results in arrested lens development in the pre-placodal stage, and neither lens placode nor lens is formed. We found that in the presumptive lens ectoderm of Meis1/Meis2 deficient embryos Pax6 expression is absent
Meis1 is a major regulator of sympathetic target-field innervation and Meis1 deficient sympathetic neurons die by apoptosis from early embryonic stages to perinatal stages.
PCBP2 overexpression rescues the Meis1 effects of Akt-mTOR pathway and hypertrophy of cardiomyocytes.
Data indicate roles of myeloid ecotropic viral integration site 1 protein (Meis1) in both megakaryopoiesis and erythropoiesis.
Tumorigenesis by Meis1 overexpression is accompanied by a change of DNA target-sequence specificity which allows binding to the AP-1 element.
Sequential binding of MEIS1 and NKX2-5 on the Popdc2 gene demonstrate a mechanism for spatiotemporal regulation of enhancers during cardiogenesis.
data point to role of Meis1 in striatal development, also supported by reduced neuronal differentiation in the lateral ganglionic eminence of Meis1(-/-) embryos
Meis1 is at the core of a genetic network implicated in eye patterning/microphthalmia.
Data indicate that Meis homeobox 1 (MEIS1) is required for the maintenance of myeloid-lymphoid leukemia protein MLL-fusion gene leukemia, and hepatic leukemia factor (HLF)is a key downstream mediator of Meis1.
Meis1 regulates epidermal stem cells and is required for skin tumorigenesis.
Meis1 is potentially involved in the maintenance of postnatal thymic epithelial cell.
deficiency of tumor suppressor prep1 accelerates the onset of meis1- hoxa9 leukemogenesis
Data indicate that loss of homeodomain transcription factor Meis1 leads to a depletion of hematopoietic progenitor cells from the bone marrow.
vivo and in vitro analysis of a common SNP with small effect size showed allele-dependent function in the prospective basal ganglia representing the first neurodevelopmental region implicated in Restless Legs Syndrome.
results suggest a previously unidentified role for C/EBPalpha in maintaining the proliferation required for Hoxa9/Meis1-mediated leukemogenesis
Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins.
Meis1, myeloid ecotropic viral integration site 1 homolog
, homeobox protein Meis1
, leukemogenic homolog protein
, XMeis1-2 protein
, Meis homeobox 1
, gene II
, homeobox protein Meis1-like
, myeloid ecotropic viral integration site 1
, myeloid ecotropic viral insertion site-1a protein