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anti-Human SMARCE1 Anticorps:
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Human Polyclonal SMARCE1 Primary Antibody pour IHC, IHC (p) - ABIN251031
Link, Balasubramaniam, Sharma, Comstock, Godoy-Tundidor, Powers, Cao, Haelens, Claessens, Revelo, Knudsen: Targeting the BAF57 SWI/SNF subunit in prostate cancer: a novel platform to control androgen receptor activity. dans Cancer research 2008
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Human Polyclonal SMARCE1 Primary Antibody pour ICC, IF - ABIN4282875
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. dans Journal of proteomics 2012
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Human Polyclonal SMARCE1 Primary Antibody pour IHC (p), IHC - ABIN249995
Wang, Chi, Xue, Zhou, Kuo, Crabtree: Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes. dans Proceedings of the National Academy of Sciences of the United States of America 1998
Human Polyclonal SMARCE1 Primary Antibody pour IHC (p), WB - ABIN658277
Watanabe, Ui, Kanno, Ogiwara, Nagase, Kohno, Yasui: SWI/SNF factors required for cellular resistance to DNA damage include ARID1A and ARID1B and show interdependent protein stability. dans Cancer research 2014
High SMARCE1 expression is associated with eventual relapse and metastasis in breast cancer.
miR (Montrer MLXIP Anticorps)-29a promotes hepatitis B virus (HBV) replication and expression through regulating SMARCE1 in HBV-infected HepG2.2.15 cells.
the malignancy risk in schwannomatosis is not well defined but may include an increased risk of malignant peripheral nerve sheath tumor in SMARCB1 (Montrer SMARCB1 Anticorps) Imaging protocols are also proposed for SMARCB1 (Montrer SMARCB1 Anticorps) and LZTR1 (Montrer LZTR1 Anticorps) schwannomatosis and SMARCE1-related meningioma predisposition.
BAF57, BAF60a (Montrer SMARCD1 Anticorps) and SNF5 (Montrer SMARCB1 Anticorps) might act as novel pro-senescence factors in both normal and tumor human skin cells
We report here three additional individuals with clinical features consistent with CSS (Montrer CMAS Anticorps) and alterations in SMARCE1, one of which is novel. The probands all exhibited dysmorphic facial features, moderate developmental and cognitive delay, poor growth, and hypoplastic digital nails/phalanges, including digits not typically affected in the other genes associated with CSS (Montrer CMAS Anticorps).
SMARCE1 mutational hits, including novel SMARCE1 mutations, were found in six of eight tested patients with clear cell meningioma
SMARCE1 plays an essential role in breast cancer metastasis by protecting cells against anoikis through the HIF1A (Montrer HIF1A Anticorps)/PTK2 (Montrer PTK2 Anticorps) pathway.
An exhaustive analysis of the BAF57 molecular and biochemical properties, cellular functions, loss-of-function phenotypes in living organisms and pathological manifestations in cases of human mutations. [review]
a family with a pediatric CCM patient and an adult CCM patient and several asymptomatic relatives carrying a germline SMARCE1 mutation.
Addition of the EGFR (Montrer EGFR Anticorps) inhibitor gefitinib restores the sensitivity of SMARCE1-knockdown cells to MET and ALK inhibitors in NSCLCs. Our findings link SMARCE1 to EGFR (Montrer EGFR Anticorps) oncogenic signaling and suggest targeted treatment options for SMARCE1-deficient tumors.
These results reveal a novel function of BAF57 as an essential regulator of T cell activation.
The N terminus of Brdt (Montrer BRDT Anticorps) is involved in the recognition of Smarce1 as well as in the reorganization of hyperacetylated round spermatid chromatin.
suggest a novel mechanism for transcriptional repression by TSHZ3 (Montrer ZNF537 Anticorps) in which TSHZ3 (Montrer ZNF537 Anticorps) and BAF57 cooperate to modulate MyoD (Montrer MYOD1 Anticorps) activity on the Myog (Montrer MYOG Anticorps) promoter to regulate skeletal muscle differentiation.
Data show that neuregulin-1 (Montrer NRG1 Anticorps) (NRG) inhibition is followed by a decrease in NSC proliferation and of neuronal or oligodendroglial differentiation, and that Nrg-1 (Montrer NRG1 Anticorps) physically interacts with BRM (Montrer SMARCA2 Anticorps) and BAF57.
Reciprocal regulation of CD4 (Montrer CD4 Anticorps)/CD8 (Montrer CD8A Anticorps) expression by SWI (Montrer SMARCA1 Anticorps)/SNF (Montrer SNRPA Anticorps)-like BAF (Montrer BANF1 Anticorps) complexes.
The ER interacts with BAF57, which is stimulated by estrogen and requires both a functional hormone-binding domain & the DNA-binding region of the ER. The p160 (Montrer MSH6 Anticorps) family of coactivators interacts with BAF57. Their potentiation of transcription depends on it.
Smarce1 (Baf27)is a critical modulator of the androgen neceptor (AR) that is capable of altering AR activity, coactivator function, and AR-dependent proliferation.
BAF (Montrer BANF1 Anticorps) complex uses BAF57 to remodel the endogenous, H1-containing chromatin at the CD4 (Montrer CD4 Anticorps) silencer, which facilitates the binding of Runx1 (Montrer RUNX1 Anticorps), a key repressor of CD4 (Montrer CD4 Anticorps) transcription.
The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1
, BRG1-associated factor 57
, SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1
, chromatin remodeling complex BRG1-associated factor 57
, SWI/SNF-related matrix-associated actin-dependent regulator chromatin subfamily E member 1