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anti-Human TFAM Anticorps:
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Cow (Bovine) Polyclonal TFAM Primary Antibody pour WB - ABIN2777277
Shi, Burkart, Nicoloro, Czech, Straubhaar, Corvera: Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells. dans The Journal of biological chemistry 2008
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Human Polyclonal TFAM Primary Antibody pour IF, IHC (p) - ABIN520832
Aamann, Sorensen, Hvitby, Berquist, Muftuoglu, Tian, de Souza-Pinto, Scheibye-Knudsen, Wilson, Stevnsner, Bohr: Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010
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Human Monoclonal TFAM Primary Antibody pour ICC, IF - ABIN4336018
Morris, Meers, Booth, Fritsche, Hardin, Thyfault, Ibdah: PGC-1α overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion. dans American journal of physiology. Gastrointestinal and liver physiology 2012
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Human Polyclonal TFAM Primary Antibody pour IF (p), IHC (p) - ABIN1387734
Yan, Ji, Shi, Li, Sang: Acute nitrogen dioxide inhalation induces mitochondrial dysfunction in rat brain. dans Environmental research 2015
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Human Polyclonal TFAM Primary Antibody pour IP, WB - ABIN520833
Vijayakumar, Wu, Buffin, Li, Sun, Gordon, Yakar, LeRoith: Skeletal muscle growth hormone receptor signaling regulates basal, but not fasting-induced, lipid oxidation. dans PLoS ONE 2012
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Human Polyclonal TFAM Primary Antibody pour WB - ABIN520834
Ivanova, Radde, Son, Mehta, Chung, Klinge: Estradiol and tamoxifen regulate NRF-1 and mitochondrial function in mouse mammary gland and uterus. dans Journal of molecular endocrinology 2013
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Human Polyclonal TFAM Primary Antibody pour IHC (p), WB - ABIN3043945
Mo, Peng, Wang, Peng, Lan, Yu: Roles of mitochondrial transcription factor A and microRNA-590-3p in the development of bladder cancer. dans Oncology letters 2013
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Human Polyclonal TFAM Primary Antibody pour ICC, IF - ABIN4336019
Sotgia, Whitaker-Menezes, Martinez-Outschoorn, Salem, Tsirigos, Lamb, Sneddon, Hulit, Howell, Lisanti: Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells. dans Cell cycle (Georgetown, Tex.) 2012
Rat (Rattus) Polyclonal TFAM Primary Antibody pour WB - ABIN411602
Arduini, Serviddio, Escobar, Tormos, Bellanti, Viña, Monsalve, Sastre: Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leading to mitochondrial DNA depletion and deletions. dans American journal of physiology. Gastrointestinal and liver physiology 2011
Human Polyclonal TFAM Primary Antibody pour ICC, IHC (fro) - ABIN3044014
Wu, Zhao, Xiao, Peng, Chen, He: Roles of mitochondrial transcription factor A and microRNA‑590‑3p in the development of colon cancer. dans Molecular medicine reports 2017
Study shows that the human mitochondrial transcription factor A (TFAM) is a versatile G-quadruplex (G4s (Montrer ARSB Anticorps)) binding protein. These TFAM-G4 interactions suggest functional recognition of G4s (Montrer ARSB Anticorps) in the mitochondria.
CTGF (Montrer CTGF Anticorps) can reduce glycolysis and mitochondrial OXPHOS pathways by increasing mtTFA protein degradation and in turn reduces cancer migration and invasion in oral squamous cell carcinoma (OSCC).
radiation stimulated the levels of TFAM mRNA and protein.
Two tag SNPs of TFAM and POLG were associated with multibacillary leprosy in Han Chinese from Southwest China.
Data revealed that TFAM expression level was regulated by TP73-AS1/miR (Montrer MLXIP Anticorps)-200a axis in breast cancer cells.
Study clearly shows that hTFAM efficiently breaks the mitochondria-mediated vicious cycle in both Alzheimer's disease (AD) model neurons and mouse brains, resulting in an effective improvement of the AD pathophysiology including Abeta (Montrer APP Anticorps) accumulation and cognitive dysfunction.
these findings establish a new link between HIF-2alpha (Montrer EPAS1 Anticorps) and MAPK (Montrer MAPK1 Anticorps)-signaling that mediates the adaptive regulation of mitochondrial gene expression under low oxygen tension.
the results presented in this study obviously provided the evidence that TFAM was upregulated in glioma cell line and glioma tissue specimens. Therefore TFAM may be a novel diagnostic marker and therapeutic target for glioma and other cancer.
Biotinylated TMP interacts with TFAM.
TFAM polymorphisms (rs1937, rs1049432, and rs11006132) as well as their haplotypes did not show significant association with aggressiveness of prostate cancer in overweight or obese men.
TFAM may exert a critical role in porcine gametogenesis and preimplantation embryo development.
Our results suggest that TFAM plays an important role in lipid metabolism and may be a strong candidate gene for obesity in mammals.
de novo mtTFA expression associated with mitochondrial biogenesis activation & high levels of nuclear respiratory factor-1 (Montrer NRF1 Anticorps) mRNA from oocyte stage onwards argue for essential function of these factors during the first steps of bovine embryogenesis.
TFAM overexpression normalizes pathological hypertrophic factor NFAT4 (Montrer NFATC3 Anticorps) in the presence of oxidative stress.
results suggest a nucleation-cooperativity-based mechanism for sensitive detection of mitochondrial DNA and pathogen genomes, and identify HMGB (Montrer FAH Anticorps)/TFAM proteins as DNA-structuring host factors; they provide an explanation for the peculiar cGAS dimer structure and suggest that cGAS preferentially binds incomplete nucleoid-like structures or bent DNA
TFAM is essential for transcription, replication and packaging of mtDNA into nucleoids. Tfam knockout mice display embryonic lethality secondary to severe mtDNA depletion. In this report, for the first time, we associate a homozygous variant in TFAM with a novel mtDNA depletion syndrome.
Perturbation of mitochondrial complex function by ablation of the mitochondrial transcription factor A (Tfam) reproduces multiple hallmarks of aging in hippocampal neurogenesis.
During muscle differentiation, Tfam protein levels are regulated by the availability of Tfam mRNA, which is controlled by both transcription and mRNA stability.
TFAM binds to RNA-containing 4-way junctions but does not bind appreciably to RNA hairpins, internal loops, or linear RNA:DNA hybrids.
Data show that mitochondrial transcription factor A (TFAM) packages single mitochondrial DNA (mtDNA) molecules.
There was upregulation of mtDNA and TFAM in 6-wk diabetic mice, suggesting that TFAM activation could be a therapeutic strategy to treat peripheral neuropathy.
This study demonistrated that Tfam gene inactive patkinsin disease cause dopamine loss and circadian rhythm disorder.
Mitochondrial transcription factor A, an endogenous danger signal, promotes TNFalpha (Montrer TNF Anticorps) release via RAGE (Montrer AGER Anticorps)- and TLR9 (Montrer TLR9 Anticorps)-responsive plasmacytoid dendritic cells.
This gene encodes a key mitochondrial transcription factor containing two high mobility group motifs. The encoded protein also functions in mitochondrial DNA replication and repair. Sequence polymorphisms in this gene are associated with Alzheimer's and Parkinson's diseases. There are pseudogenes for this gene on chromosomes 6, 7, and 11. Alternative splicing results in multiple transcript variants.
transcription factor A, mitochondrial
, HMG box mitochondrial transcription factor
, mitochondrial transcription factor 1
, mitochondrial transcription factor A
, transcription factor 6
, transcription factor 6-like 1
, transcription factor 6-like 2 (mitochondrial transcription factor)
, transcription factor 6-like 3
, transcription factor 6-like 2
, testis-specific HMG-box protein m-tsHMG
, testis-specific high mobility group protein