Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher tous les synonymes
Sélectionnez vos espèces d'intérêt
Caspase-11 (Montrer CASP4 Protéines) targets cofilin (Montrer CFL1 Protéines) via the RhoA GTPase, whereas caspase-1 (Montrer CASP1 Protéines) engages the Slingshot phosphatase
SSH1L knockdown, like S1P (Montrer S1PR1 Protéines) treatment, increased cardiomyocyte survival and preserved mitochondrial integrity after oxidative stress
EphA signaling promotes actin-based dendritic spine remodeling through slingshot 1.
PDGF (Montrer PDGFA Protéines) activates SSH1L in VSMC by a mechanism that involves Nox1 (Montrer NOX1 Protéines)-mediated oxidation of 14-3-3 (Montrer YWHAQ Protéines) and Ser (Montrer SIGLEC1 Protéines)-834 SSH1L auto-dephosphorylation.
Knockdown of SSH1 expression by RNA interference significantly suppressed stress fiber formation in C2C12 myoblast cells, indicating a role for SSH1 in stress fiber formation or stabilization in cells.
SSH1 binds to gelsolin (Montrer GSN Protéines) via actin filaments in the cytosolic fraction. Gelsolin (Montrer GSN Protéines) promoted solubilization of actin filaments and SSH1 in cell-free assays and in cultured cells.
the N-terminal PH-like domain plays a critical role in F-actin binding and F-actin-mediated activation of the cofilin (Montrer CFL1 Protéines)-phosphatase activity of SSH1
Results reveal that SSH1L is upregulated in a subset of PCs and that the SSH1L/cofilin-1 (Montrer CFL1 Protéines) signal pathway is associated positively in PC with cell migration.
Authors show that viral penetration-induced calcium release facilitated herpes simplex virus type 1 intracellular trafficking through activating slingshot 1 (SSH), a phosphatase regulating actin filament dynamics.
The association of IRS4 (Montrer IRS4 Protéines) with SSH1 contributes to localized activation of cofilin (Montrer CFL1 Protéines) in membrane protrusions.
Slingshot 1 downregulation in neuronal cells inactivates cofilin (Montrer CFL1 Protéines) to facilitate HSV-1 replication.
Thus this study provides evidence for a novel role of LIMK1 (Montrer LIMK1 Protéines) and SSH-1L in selectively regulating endothelial cell inflammation associated with intravascular coagulation.
Our work provides evidence that supports the positive role of SSH1L in the mechanism of stem cell differentiation into cardiomyocyte-like cells.
A high expression of SSH-1L in peripheral eosinophils in acute exacerbations of asthma may play a role in the activation and migration of eosinophils.
The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
, SSH-like protein 1
, protein phosphatase Slingshot homolog 1
, slingshot 1L
, slingshot-like 1
, slingshot homolog 1