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anti-Human Aurora A Anticorps:
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Human Polyclonal Aurora A Primary Antibody pour ICC, IF - ABIN151704
Saskova, Solc, Baran, Kubelka, Schultz, Motlik: Aurora kinase A controls meiosis I progression in mouse oocytes. dans Cell cycle (Georgetown, Tex.) 2008
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Human Polyclonal Aurora A Primary Antibody pour FACS, IF - ABIN1882163
Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ... dans Proceedings of the National Academy of Sciences of the United States of America 2002
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Human Polyclonal Aurora A Primary Antibody pour ICC, IF - ABIN151735
Hontz, Li, Lingle, Negron, Bruzek, Salisbury, Li: Aurora a and B overexpression and centrosome amplification in early estrogen-induced tumor foci in the Syrian hamster kidney: implications for chromosomal instability, aneuploidy, and neoplasia. dans Cancer research 2007
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Human Polyclonal Aurora A Primary Antibody pour ICC, IF - ABIN4282417
Honma, Nakanishi, Nakanoko, Ando, Saeki, Oki, Iimori, Kitao, Kakeji, Maehara: Contribution of Aurora-A and -B expression to DNA aneuploidy in gastric cancers. dans Surgery today 2014
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Human Monoclonal Aurora A Primary Antibody pour IF, IP - ABIN2477554
Quinn, Crane, Kocal, Best, Cameron, Rushmore, Farber, Hayes: Protective activity of different hepatic cytosolic glutathione S-transferases against DNA-binding metabolites of aflatoxin B1. dans Toxicology and applied pharmacology 1990
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Human Monoclonal Aurora A Primary Antibody pour IF, WB - ABIN2477555
Cremet, Descamps, Vérite, Martin, Prigent: Preparation and characterization of a human aurora-A kinase monoclonal antibody. dans Molecular and cellular biochemistry 2003
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Human Monoclonal Aurora A Primary Antibody pour IHC, ELISA - ABIN968972
Veerakumarasivam, Goldstein, Saeb-Parsy, Scott, Warren, Thorne, Mills, Venkitaraman, Neal, Kelly: AURKA overexpression accompanies dysregulation of DNA-damage response genes in invasive urothelial cell carcinoma. dans Cell cycle (Georgetown, Tex.) 2008
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Human Monoclonal Aurora A Primary Antibody pour ICC, FACS - ABIN968971
De Luca, Brunetto, Asteriti, Giubettini, Lavia, Guarguaglini: Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity. dans Oncogene 2008
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Human Monoclonal Aurora A Primary Antibody pour IF, IHC (p) - ABIN563053
Lo Iacono, Monica, Saviozzi, Ceppi, Bracco, Papotti, Scagliotti: Aurora Kinase A expression is associated with lung cancer histological-subtypes and with tumor de-differentiation. dans Journal of translational medicine 2011
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WDR62 (Montrer WDR62 Anticorps) controls brain growth through lineage-specific interactions with master mitotic signaling kinase, aurora A kinase.
Disrupting the spindle assembly checkpoint in the aurA mutant does not prevent neuroblast amplification, tumor formation or chromosome segregation.
Aurora A kinase activity contributes to phosphorylation of kinetochore substrates near poles and its inhibition results in chromosome misalignment and an increased incidence of erroneous kinetochore-MT attachments.
AurA and aPKC exert the spatiotemporal control of Lgl distribution to achieve unique cell polarity roles in distinct cell types.
Aurora A and B kinases directly phosphorylate Lgl to promote its mitotic relocalization.
Drosophila melanogaster aurora A phosphorylates the dynactin (Montrer DCTN1 Anticorps) subunit p150(glued (Montrer DCTN1 Anticorps)) on sites required for its association with the mitotic spindle.
One of the functions of Aurora A kinase is to direct centrosomal organization such that D-TACC complexed to the MSPS/XMAP215 (Montrer CKAP5 Anticorps) microtubule-associated protein (Montrer FAM82A2 Anticorps) may be recruited, and thus modulate the behavior of astral microtubules.
Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis.
Deletion mapping identifies a central domain of Aurora-A as essential for its centrosomal localization that is augmented by both the amino and the carboxyl terminal ends of the protein.
Results suggest that Aurora-A regulates centrosome assembly by controlling centrosomin's (CNN) ability to target and/or anchor gamma-tubulin (Montrer TUBG1 Anticorps) to the centrosome and to organize microtubule-nucleating sites via interaction with CNN.
Zebrafish Aurora-A is critically required for embryonic proliferation during development.
Findings suggest that ATP/GTP binding protein like 2 (AGBL2 (Montrer AGBL2 Anticorps)) plays a critical oncogenic role in the pathogenesis of hepatocellular carcinoma (HCC (Montrer FAM126A Anticorps)) through modulation on immunity-related GTPase (Montrer RACGAP1 Anticorps) family, M protein (Montrer MYOM2 Anticorps) (IRGM (Montrer IRGM Anticorps))-regulated autophagy and aurora kinase A (Aurora A) activity.
Polymorphisms of the Aurora Kinase a Gene is associated with Breast Cancer Risk.
Study suggests AURKA and TPX2 (Montrer TPX2 Anticorps) as potential stratification markers for taxane-based radiochemotherapy. lung adenocarcinoma cohort, high expression levels of AURKA and TPX2 (Montrer TPX2 Anticorps) were associated with specifically improved overall survival upon taxane-based radiochemotherapy.
In all, these data suggest that Aurora A plays a pivotal role in regulation of Androgen receptor (Montrer AR Anticorps) variant 7 expression and represents a new therapeutic target in castrate-resistant prostate cancer.
The inverse correlation between the VHL (Montrer VHL Anticorps) gene expression profile and alisertib sensitivity was further confirmed in human cancer xenografts models. Taken together, these results suggested that VHL (Montrer VHL Anticorps) loss could potentially serve as a biomarker for predicting the efficacy of AURKA inhibitors.
LKB1 (Montrer STK11 Anticorps) undergoes AURKA-mediated phosphorylation, which largely compromises the LKB1 (Montrer STK11 Anticorps)/AMPK (Montrer PRKAA1 Anticorps) signaling axis, in turn leading to the elevation of non-small cell lung cancer cell proliferation, invasion and migration.
Epithelial ovarian cancer (EOC) cell apoptosis rate was repressed after treatment with lncRNA TUG1 mimic and promoted after treatment with lncRNA TUG1 inhibitor. AURKA expression but not CLDN3 (Montrer CLDN3 Anticorps), SERPINE1 (Montrer SERPINE1 Anticorps), or ETS1 (Montrer ETS1 Anticorps) expression was adversely regulated by lncRNA TUG1 mimic and inhibitor. In conclusion, lncRNA TUG1 promotes cells proliferation and inhibits cells apoptosis through regulating AURKA in EOC cells.
Src (Montrer SRC Anticorps) and Aurora-A interact upon Golgi ribbon fragmentation; Src (Montrer SRC Anticorps) phosphorylates Aurora-A at tyrosine 148 and this specific phosphorylation is required for Aurora-A localization at the centrosomes.
Metformin disrupts malignant behavior of oral squamous cell carcinoma via a novel signaling involving Late SV40 factor/Aurora-A. Findings showed that a novel Late SV40 Factor and Aurora-A-signaling inhibition supports the rationale of using metformin as potential oral squamous cell carcinoma therapeutics.
The present study confirmed that pAURKA is important in the development of gastric adenocarcinoma and revealed a novel functional link between PTEN, AURKA and pAURKA activation.
ex vivo cells derived from teratomas exhibited high self-renewal capacity that was linked to Aurora-A kinase activity and gave rise to lung metastasis when injected into the tail vein of immunocompromised mice.
Aurora A and Plk4 (Montrer PLK4 Anticorps) are rate-limiting factors contributing to microtubule growth as the acentriolar oocyte resumes meiosis.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB (Montrer AURKB Anticorps) or AURKC (Montrer AURKC Anticorps) using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA expression is crucial for spindle formation in meiosis
Aurora kinase inhibitor CCT137690 induces necrosis-like death in pancreatic ductal adenocarcinoma cells, via RIPK1, RIPK3, and MLKL signaling.
CIP2A (Montrer KIAA1524 Anticorps) acts as a scaffold for CEP192-mediated microtubule organizing center assembly by recruiting Plk1 and aurora A during meiotic maturation in mouse oocytes
AURKA stabilizes MYC (Montrer MYC Anticorps) to promote tp53 (Montrer TP53 Anticorps)-altered liver tumor cell survival.
Bcl2l10 (Montrer BCL2L10 Anticorps), Tpx2 (Montrer DAZL Anticorps), and Aurka co-localized on the meiotic spindles, and Bcl2l10 (Montrer BCL2L10 Anticorps) was present in the same complex with Tpx2 (Montrer DAZL Anticorps).
Suppression of neuroendocrine and NEPC development by ICT was associated with dose-dependent inhibitory effects on abnormally elevated IL-6 (Montrer IL6 Anticorps)/STAT3 (Montrer STAT3 Anticorps) and Aurora kinase A in vitro and in vivo
Our findings demonstrate that prolonged overexpression of Aurora-A can be a driver somatic genetic event in mammary adenocarcinomas associated with deregulated tumor-relevant pathways in the Aurora-A subset of human breast cancer
Data show that aurora-A kinase (AURKA) supports effective spindle formation in zygote.
Aurora A was the most abundant form in oocytes, both at mRNA and protein levels, in bovine oocytes during meiotic maturation.
Aurora kinase A is unlikely to be involved in CPEB1 (Montrer CPEB1 Anticorps) activating phosphorylation and cyclin B1 (Montrer CCNB1 Anticorps) mRNA polyadenylation during meiotic maturation of porcine oocytes.
Aurora-A may be a multifunctional kinase that plays pivotal regulatory roles in microtubule assembly during porcine oocyte meiotic maturation, fertilization and early embryonic mitosis
Aurora A stimulates the protein synthesis and promotes the meiotic resumption.
These results suggest a novel relationship between AurA and protein phosphatases during progression throughout the early embryonic cell cycle and shed new light on potential defects caused by AurA overexpression.
MCAK (Montrer KIF2C Anticorps) colocalized with NuMA and XMAP215 (Montrer CKAP5 Anticorps) at the center of Ran asters where its activity is regulated by Aurora A-dependent phosphorylation of S196, which contributes to proper pole focusing
Plx1 promotes activation of Aurora A, most likely through TPX2.
Aurora-A kinase is required for astral microtubule polymerization and spindle microtubule flux during chromosome segregation.
Data show that Aurora A is a key regulator of microtubule assembly during M phase and therefore of bipolar spindle formation.
binding and elution properties of both the phosphopeptides and unphosphorylated peptides of His6-Aurora A
Results suggest that phosphorylation of maskin (Montrer TACC3 Anticorps) by Aurora-A prevents meiosis II proteins from being produced during meiosis I.
The N-terminal non-catalytic domain of Aurora-A can localize to the centrosome in Xenopus egg extracts, while GFP fusions of either the N-terminal or catalytic domains are targeted to the centrosome in Xenopus XL2 cells.
Here we identify G205 in Xenopus Aurora A as a key determinant of both intrinsic activity and regulation by TPX2
The catalytic domain alone of Aurora-A is sufficient to restore spindle bipolarity; additional N-terminal sequences function in mitotic timing.
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.
A-type aurora kinase
, aurora A
, aurora A kinase
, aurora kinase
, Aurora A
, hypothetical protein
, aurora kinase A
, serine/threonine-protein kinase 6
, serine/threonine protein kinase 6
, aurora A kinase protein
, serine/threonine-protein kinase 6-like
, Aurora-A kinase
, IPL1-related kinase
, aurora 2
, aurora-related kinase 1
, aurora/IPL1-like kinase
, aurora/IPL1-related kinase 1
, breast tumor-amplified kinase
, breast-tumor-amplified kinase
, protein phosphatase 1, regulatory subunit 47
, serine/threonine kinase 6
, serine/threonine protein kinase 15
, serine/threonine-protein kinase 15
, serine/threonine-protein kinase aurora-A
, aurora family kinase 1
, ipl1- and aurora-related kinase 1
, serine/threonine-protein kinase Ayk1
, Serine/threonine-protein kinase 6
, aurora kinase A-A
, serine/threonine-protein kinase 6-A
, serine/threonine-protein kinase Eg2
, serine/threonine-protein kinase Eg2-A