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anti-Human BMI1 Anticorps:
anti-Mouse (Murine) BMI1 Anticorps:
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Human Monoclonal BMI1 Primary Antibody pour BI, IHC (f) - ABIN2688857
Dimri, Martinez, Jacobs, Keblusek, Itahana, Van Lohuizen, Campisi, Wazer, Band: The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. dans Cancer research 2002
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Human Monoclonal BMI1 Primary Antibody pour ICC, FACS - ABIN968985
Edwards, Witherspoon, Wang, Afrasiabi, Pham, Birnbaumer, Lipkin: Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer. dans Cancer research 2009
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Human Monoclonal BMI1 Primary Antibody pour ChIP - ABIN2668619
Lafkas, Rodilla, Huyghe, Mourao, Kiaris, Fre: Notch3 marks clonogenic mammary luminal progenitor cells in vivo. dans The Journal of cell biology 2013
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Human Monoclonal BMI1 Primary Antibody pour ELISA, WB - ABIN560071
Andrews, Banting, Damjanov, Arnaud, Avner: Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells. dans Hybridoma 1985
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Human Polyclonal BMI1 Primary Antibody pour ICC, IF - ABIN152245
Kang, Qi, Zuo, Wang, Zou, Schwartz, Cheng, Yeh: SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. dans Molecular cell 2010
Human Polyclonal BMI1 Primary Antibody pour IHC (fro), WB - ABIN2477677
Mandal, Boitano, Maxwell, Lou, Alexander: Ninety-eight penetrating vascular injuries: a review of a two and one-half year experience. dans The Journal of trauma 1976
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Human Polyclonal BMI1 Primary Antibody pour ICC, IF - ABIN257760
Ismail, Andrin, McDonald, Hendzel: BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. dans The Journal of cell biology 2010
Human Monoclonal BMI1 Primary Antibody pour ICC, IF - ABIN2668620
Bracken, Kleine-Kohlbrecher, Dietrich, Pasini, Gargiulo, Beekman, Theilgaard-Mönch, Minucci, Porse, Marine, Hansen, Helin: The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. dans Genes & development 2007
Human Monoclonal BMI1 Primary Antibody pour ChIP, ICC - ABIN4284857
Courel, Friesenhahn, Lees: E2f6 and Bmi1 cooperate in axial skeletal development. dans Developmental dynamics : an official publication of the American Association of Anatomists 2008
Human Monoclonal BMI1 Primary Antibody pour CyTOF, FACS - ABIN4900505
Shen, Chen, Ding, Qi, Cen, Wang, Yao, Chen: BMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression. dans Journal of cellular and molecular medicine 2014
These preclinical data in mouse models and human cells provide a strong rationale for the development of pharmacological approaches to target BMI1-mediated mitochondrial regulation and protection from DNA damage to sustain the regenerative potential of the skeletal muscle in conditions of chronic muscle wasting.
Authors found that compared with control subjects, BMI1 mRNA expression in whole blood of advanced NSCLC patients was decreased. Similarly, authors observed decreased BMI1 mRNA expression in primary tumors compared to normal lungs from operable NSCLC patients.
study revealed a molecular pathway consisting of BMI1, miRNA let-7i, and ERK3 (Montrer MAPK4 Anticorps), which controls the migration of head and neck cancer cells, and suggests that ERK3 (Montrer MAPK4 Anticorps) kinase is a potential new therapeutic target in head and neck cancers, particularly those with BMI1 overexpression.
Study suggests that BMI-1 is involved in the cellular premature senescence of human dental pulp stem cells triggered by oxidative stress.
our study demonstrates that USP22 (Montrer USP22 Anticorps) is indispensable for gastric cancer stem cell self-renewal through stabilization of BMI1.
elevating the levels of BMI1 regulated miRNAspromoted Mesenchymal to Epithelial transition by regulating the expression of N-Cadherin (Montrer CDH2 Anticorps), Vimentin (Montrer VIM Anticorps), beta-Catenin (Montrer CTNNB1 Anticorps), Zeb (Montrer ZEB1 Anticorps), Snail (Montrer SNAI1 Anticorps) thereby resulting in decreased invasion, migration and proliferation
BMI-1, TIM-3 (Montrer HAVCR2 Anticorps) and CLL-1 (Montrer COLEC10 Anticorps) have roles in acute myeloid leukemia (Montrer BCL11A Anticorps) prognosis and therapy
miR128-1 could function as a tumor suppressor in glioblastoma multiforme by negatively regulating tumor cell proliferation, invasion and self-renewal through direct targeting BMI1 and E2F3.
these data suggest that Bmi-1 could serve as a novel prognostic biomarker in pediatric primary acute lymphoblastic leukemia (ALL)and may be partially regulated by Sall4a (Montrer SALL4 Anticorps). Our study also showed that Bmi-1 could serve as a new therapeutic target for the treatment of pediatric ALL.
The findings indicate that BMI1-mediated IDAX (Montrer CXXC4 Anticorps) epigenetic suppression is crucial for enhancement of colon carcinogenesis.
miR (Montrer MLXIP Anticorps)-203 is repressed by EZH2 (Montrer EZH2 Anticorps) in both embryonic and adult neural stem/progenitor cells (NSPCs). MiR (Montrer MLXIP Anticorps)-203 negatively regulates the proliferation of NSPCs. One of PRC1 (Montrer PRC1 Anticorps) components, Bmi1, is a downstream target of miR (Montrer MLXIP Anticorps)-203 in NSPCs.
Data suggest BMI1 overexpression as a novel mechanism leading to EphA7 (Montrer EPHA7 Anticorps) inactivation via H3K27 trimethylation and DNA methylation (Montrer HELLS Anticorps) by which BMI-1 controls cell proliferation in the postnatal lateral ventricle wall.
Bmi1 plays an important role in regulating the proliferation of cochlear supporting cells.
Results from this study indicate that estrogen deficiency downregulates BMI-1 and subsequently increases ROS (Montrer ROS1 Anticorps), T cell activation, and RANKL (Montrer TNFSF11 Anticorps) production in T cells, thus enhancing osteoclastogenesis and accelerating bone loss.
ompounding a previously described Bmi1-transgene and Pten-deficiency prostate cancer mouse model with the Ezh2 (Montrer EZH2 Anticorps) transgene did not enhance tumour progression or drive metastasis formation. In conclusion, we here report the generation of a wildtype Ezh2 (Montrer EZH2 Anticorps) overexpression mouse model that allows for intravital surveillance of tissues with activated transgene
BMI1 and MEL18 (Montrer PCGF2 Anticorps) contribute to the development of colitis-associated cancer in mice by promoting proliferation and reducing apoptosis via suppressing expression of Reg3b (Montrer REG3B Anticorps). REG3B (Montrer REG3B Anticorps) negatively regulates cytokine-induced activation of STAT3 (Montrer STAT3 Anticorps) in colon epithelial cells.
Data show that C/EBPalpha (Montrer CEBPA Anticorps) is a tumor suppressor in lung cancer and that BMI1 is required for the oncogenic process downstream of C/EBPalpha (Montrer CEBPA Anticorps) loss.
KLF4 (Montrer KLF4 Anticorps) modulates development of BMI1-expressing intestinal stem cell-derived lineage following gamma-radiation-induced gut (Montrer GUSB Anticorps) injury in mice.
The retinal phenotype of Bmi1(-/-) mice was characterized by loss of heterochromatin, activation of tandem repeats, oxidative stress and Rip3 (Montrer MPRIP Anticorps)-associated necroptosis.
Loss of BMI1 enhanced ribonuclease activity of polynucleotide phosphorylase and reduced mtRNA stability
Bmi1 acts immediately downstream of CCAAT enhancer binding protein-alpha (Montrer CEBPA Anticorps) to regulate the survival and self-renewal of hematopoietic stem cells and contribute to the erythropoietic dysplasia.
Pig Bmi1 cDNA is 3,193 bp in length and consists of a 981 bp open reading frame, a 256 bp 5 (Montrer HSPD1 Anticorps)' untranslated region (UTR (Montrer UTS2R Anticorps)), and a 1,956 bp 3 (Montrer BST1 Anticorps)' UTR (Montrer UTS2R Anticorps). The transcript contains no signal peptides and there are no transmembrane regions in the pig Bmi1 coded protein.
Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2 (By similarity).
B lymphoma Mo-MLV insertion region 1 homolog
, murine leukemia viral (bmi-1) oncogene homolog
, polycomb complex protein BMI-1
, polycomb group RING finger protein 4
, polycomb group protein Bmi1
, ring finger protein 51
, BMI1 polycomb ring finger oncogene
, B lymphoma Mo-MLV insertion region 1
, polycomb group ring finger 4
, polycomb complex protein BMI-1-A
, polycomb group RING finger protein 4-A
, B lymphoma Mo-MLV insertion region
, Polycomb group RING finger protein 4-B
, polycomb complex protein BMI-1-B
, polycomb group RING finger protein 4-B
, oncoprotein BMI-1