Profil protéine

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class\; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6.

Alternative names and synonyms associated with BTRC

• beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC) anticorps
• beta-transducin repeat containing E3 ubiquitin protein ligase (btrc) anticorps
• beta-transducin repeat containing (btrc) anticorps
• beta-TrCP (LOC100634006) anticorps
• beta-transducin repeat containing E3 ubiquitin protein ligase (Btrc) anticorps
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• beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog (btrc.S) anticorps
• beta-transducin repeat containing protein (Btrc) anticorps

• b-TrCP anticorps
• BETA-TRCP anticorps
• Beta-Trcp1 anticorps
• betaTrCP anticorps
• btrc anticorps
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• btrc-a anticorps
• bTrCP anticorps
• bTrCP1 anticorps
• Fbw1a anticorps
• FBXW1 anticorps
• FBXW1A anticorps
• FWD1 anticorps
• HOS anticorps
• mKIAA4123 anticorps
• Slimb anticorps

Protein level used designations for BTRC

beta-transducin repeat containing , beta-transducin repeat containing protein , F-box/WD repeat-containing protein 1A , f-box/WD repeat-containing protein 1A-like , E3RSIkappaB , F-box and WD repeats protein beta-TrCP , F-box and WD-repeat protein 1B , beta-TrCP1 , epididymis tissue protein Li 2a , pIkappaBalpha-E3 receptor subunit , beta-TrCP , beta-transducin repeat-containing protein , SCF b-TRCP , beta-TrCP protein E3RS-IkappaB , mE3RS-IkappaB , pIkappaB-E3 receptor subunit , ubiquitin ligase FWD1