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Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2712289
Thompson, Larson, Vidrine, Barrios, Navarro, Meyers, Simms, Prajapati, Chitsike, Hellman, Baker, Watkins: FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function. dans Journal of immunology (Baltimore, Md. : 1950) 2015
Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2721367
Nott, Cheng, Gao, Lin, Gjoneska, Ko, Minhas, Zamudio, Meng, Zhang, Jin, Tsai: Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. dans Nature neuroscience 2016
Cytoplasmic retention of FOXO3a may represent a potential biomarker for response to combined treatment with inhibitors of PI3K (Montrer PIK3CA Protéines) and autophagy in PIK3CA (Montrer PIK3CA Protéines)-mutant cervical cancer cells.
Results show that FOXO3-phosphorylation at threonine-32 (T32) and nuclear localization in neuroblastoma (Montrer ARHGEF16 Protéines) biopsies significantly correlated with stage IV disease. Data suggest that, depending on the mode and intensity of activation, cellular FOXO3 acts as a homeostasis regulator promoting tumor growth at hypoxic conditions and tumor angiogenesis in high-stage neuroblastoma (Montrer ARHGEF16 Protéines).
FoxO3a might be a key regulator in cetuximab resistance through up-regulating c-Myc (Montrer MYC Protéines) in colorectal cancer targeted therapy.
Atorvastatin strengthens Skp2 binding to FOXO1 or ICAM1, leading to ubiquitination and degradation. Skp2-dependent ubiquitination of major pathogenic molecules is the key mechanism for statin's protective effect on endothelial function in diabetes.
Transcriptional factor PAX3 (PAX3 (Montrer PAX3 Protéines)) exerted its tumor suppressor function by inhibiting the activity of major signaling pathways and enhancing expression and activity of transcription factor forkhead box O3 protein (FOXO3a).
The result suggests that FOXO3 rs12212067 polymorphism does not play an important role in susceptibility to T. cruzi infection and/or chronic Chagas cardiomyopathy.
Overexpression of circ-Foxo3 decreased the interaction between Foxo3 and MDM2 (Montrer MDM2 Protéines), and repressed the function of MDM2 (Montrer MDM2 Protéines) in modulating poly-ubiquitination of Foxo3.
silencing FOXO3 diminishes bepridil- and trifluoperazine-induced apoptosis in triple-negative breast cancer cells
Combined treatment with gamma-irradiation (gammaIR) and a dual PI3K (Montrer PIK3CA Protéines)/mTOR (Montrer FRAP1 Protéines) inhibitor causes loss of stemness and of FoxO1 (Montrer FOXO1 Protéines)/3 proteins in p53 (Montrer TP53 Protéines)-proficient glioblastoma multiforme stem cells (GBM-SCs (Montrer TWIST1 Protéines)).
The authors found that transient TUBB3 (Montrer TUBB3 Protéines) activation, through ABCB1 (Montrer ABCB1 Protéines), in response to the stimulation of FOXO3a expression, significantly contributes to the cross-resistance of the paclitaxel-resistant cell population and consequently limits the efficacy of both agents where cancer cells have developed multiple resistance.
These results indicate that myostatin (Montrer MSTN Protéines) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (Montrer NR3C1 Protéines) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (Montrer AKT1 Protéines) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL (Montrer VHL Protéines), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
miR (Montrer MLXIP Protéines)-34a might suppress the excessive autophagic activity in alveolar type II epithelial AT-II cells via targeting FoxO3 to reduce the damage of LPS (Montrer TLR4 Protéines)-induced Acute Lung Injury.
PPE effectively attenuated oxidative stress and ototoxicity by regulating FoxO3a, and may thus prove to be beneficial in protecting auditory cells from ototoxic drugs.
Results show that Foxo3a is depressed in the nucleus while autophagy is impaired, and NLRP3 (Montrer NLRP3 Protéines) inflammasome is activated in Kupffer cells (KCs). Over-expression of Foxo3a restores autophagy flux and attenuates activation of the NLRP3 (Montrer NLRP3 Protéines) inflammasome via promoting the transcription of Bim (Montrer BCL2L11 Protéines).
Data indicate that forkhead box O3 (FoxO3) has a central role in the neuronal reprogramming susceptibility of cells, and the importance of FoxO3 appears to change during development.
These results suggest that lack of FXR (Montrer NR1H4 Protéines) impaired FoxO3a-mediated autophagy and in turn exacerbated alcohol-induced liver injury
pro-apoptotic role of miR (Montrer MLXIP Protéines)-34a in PA-induced cholangiocyte lipoapoptosis in culture and in the liver
data show that the GSK3B-FOXO3 pathway is activated after partial hepatectomy, and this may be one of the mechanisms that lead to upregulation of hepatic IGF1R (Montrer IGF1R Protéines) after partial hepatectomy.
BIM (Montrer BCL2L11 Protéines)-dependent death during CD8 (Montrer CD8A Protéines)(+) T-cell deletion is FOXO3 independent.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (Montrer MUL1 Protéines) FBXO32/atrogin-1 (Montrer FBXO32 Protéines) and its transcription factor FOXO3A.
MiR (Montrer MLXIP Protéines)-182-5p protects inner ear hair cells from cisplatin-induced apoptosis by inhibiting FOXO3a.
NO/protein kinase (Montrer CDK7 Protéines) G (PKG (Montrer PRKG1 Protéines))-dependent downregulation of PGC-1 alpha and the ROS (Montrer ROS1 Protéines) detoxification system in endothelial cells are mediated by the PI3K/Akt (Montrer AKT1 Protéines) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (Montrer ROS1 Protéines)-induced apoptosis in mammalian cells.
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like