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Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2712289
Thompson, Larson, Vidrine, Barrios, Navarro, Meyers, Simms, Prajapati, Chitsike, Hellman, Baker, Watkins: FOXO3-NF-κB RelA Protein Complexes Reduce Proinflammatory Cell Signaling and Function. dans Journal of immunology (Baltimore, Md. : 1950) 2015
Human FOXO3 Protein expressed in HEK-293 Cells - ABIN2721367
Nott, Cheng, Gao, Lin, Gjoneska, Ko, Minhas, Zamudio, Meng, Zhang, Jin, Tsai: Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior. dans Nature neuroscience 2016
Findings determined that the crucial regions corresponding to the SP1 (Montrer PSG1 Protéines) binding sites located between 2,000 and 1,037 bp were essential for FoxO3a transcriptional activity. Furthermore, FoxO3a transcription was upregulated in response to hypoxic and oxidative stress in colorectal tumor cells (CRC (Montrer CALR Protéines)), indicating that the interaction between SP1 (Montrer PSG1 Protéines) and FoxO3a may have important implications in CRC (Montrer CALR Protéines) progression.
FOXO3a expression correlated with adverse clinicopathological features, such as lymph node metastasis, perineural invasion and higher Ki-67 (Montrer MKI67 Protéines) proliferation index in triple-negative breast cancers.
human FOXO3B locus encodes a bona fide human gene; unlike FOXO3A, FOXO3B is cytosolically localized in both the presence and absence of active Akt (Montrer AKT1 Protéines)
FoxO3a overexpression increased the transcription and protein expression of Bcl2like protein 11 and cyclindependent kinase inhibitor 1B, and inhibited cyclin D1 (Montrer CCND1 Protéines) transcription and expression.
miR-132 negatively regulates palmitate induced NLRP3 inflammasome activation through FOXO3 down-regulation in THP-1 cells.
these data ascertain the existence of an H2O2-sensitive PRDX1 (Montrer PRDX1 Protéines)-FOXO3 signaling axis that fine tunes FOXO3 activity toward the transcription of gene targets in response to oxidative stress.
results suggested that SIRT1 (Montrer SIRT1 Protéines) deficiency in Bladder cancer cells could suppress cell viability by activating antioxidant response and inducing cell cycle arrest possibly via FOXO3a-related pathways.
these results suggest that miR (Montrer MLXIP Protéines)-30b plays important roles in kynurenine-induced increase of FOXO3 expression
Authors found that miR (Montrer MLXIP Protéines)-629 negatively regulated FOXO3 protein expression and decreased the activity of a luciferase reporter construct containing the FOXO3 3'-untranslated region. These results show that miR (Montrer MLXIP Protéines)-629 regulates FOXO3 at the posttranscriptional level, resulting in enhanced cell proliferation and invasion of pancreatic carcinoma.
auranofin could regulate the Her2 (Montrer ERBB2 Protéines)/Akt (Montrer AKT1 Protéines)/FOXO3 signaling pathway in SKOV3 cells and be used as a potential antitumor agent considering the expression of MUC4 (Montrer MUC4 Protéines) in ovarian cancer patients.
These results indicate that myostatin (Montrer MSTN Protéines) mediates maternal low protein diet-induced growth retardation, through epigenetic regulation involving FoxO3 and glucocorticoid receptor (Montrer NR3C1 Protéines) binding to its promoter.
In granulosa cells, cell death is induced by transfection of FOXO3. FOXO3 mRNA in granulosa cells increases during atresia; FOXO3 protein is abundant in granulosa cells of early atretic follicles. (FOXO3 AA sequence homology with human/mouse FOXO3)
PTEN, FOXO3A and PKB (Montrer AKT1 Protéines) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.
Primordial oocytes are dormant in prepubertal pigs by a FOXO3-related mechanism to establish a nongrowing oocyte pool in the ovary, and that a transient knockdown of the FOXO3 activates the primordial oocytes to enter the growth phase.
FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea
by modulating hypoxia-inducible factor activity via up-regulation of VHL (Montrer VHL Protéines), FOXO3a (foxo3b) plays an important role in survival in response to hypoxic stress.
This study provided novel evidence of FoxO3a in the embryonic neurodevelopment from zebrafish to other mammals.
These results reveal mechanisms by which FoxO3a promotes host survival during infection with chronic, virulent intracellular bacteria.
findings demonstrate that the mTORC2 (Montrer CRTC2 Protéines)/AKT (Montrer AKT1 Protéines)/FOXO3a axis plays a critical role in the anti-proliferative and pro-apoptotic effects of lycopene in UVB-induced photocarcinogenesis.
Melanoma dormancy in a mouse model is linked to GILZ (Montrer TSC22D3 Protéines)/FOXO3A-dependent quiescence of disseminated stem-like cells
data showed that Klotho (Montrer KL Protéines) protects Tac (Montrer IL2RA Protéines)-induced oxidative stress by negatively regulating the PI3K/AKT (Montrer AKT1 Protéines) pathway and subsequently enhancing FoxO3a-mediated MnSOD (Montrer SOD2 Protéines) expression.
miR (Montrer MLXIP Protéines)-34a might suppress the excessive autophagic activity in alveolar type II epithelial AT-II cells via targeting FoxO3 to reduce the damage of LPS (Montrer TLR4 Protéines)-induced Acute Lung Injury.
PPE effectively attenuated oxidative stress and ototoxicity by regulating FoxO3a, and may thus prove to be beneficial in protecting auditory cells from ototoxic drugs.
Results show that Foxo3a is depressed in the nucleus while autophagy is impaired, and NLRP3 (Montrer NLRP3 Protéines) inflammasome is activated in Kupffer cells (KCs). Over-expression of Foxo3a restores autophagy flux and attenuates activation of the NLRP3 (Montrer NLRP3 Protéines) inflammasome via promoting the transcription of Bim (Montrer BCL2L11 Protéines).
Data indicate that forkhead box O3 (FoxO3) has a central role in the neuronal reprogramming susceptibility of cells, and the importance of FoxO3 appears to change during development.
These results suggest that lack of FXR (Montrer NR1H4 Protéines) impaired FoxO3a-mediated autophagy and in turn exacerbated alcohol-induced liver injury
pro-apoptotic role of miR (Montrer MLXIP Protéines)-34a in PA-induced cholangiocyte lipoapoptosis in culture and in the liver
NO/protein kinase (Montrer CDK7 Protéines) G (PKG (Montrer PRKG1 Protéines))-dependent downregulation of PGC-1 alpha and the ROS (Montrer ROS1 Protéines) detoxification system in endothelial cells are mediated by the PI3K/Akt (Montrer AKT1 Protéines) signaling pathway and subsequent inactivation of transcription factor Foxo3a.
FOXO is a key regulator of ROS (Montrer ROS1 Protéines)-induced apoptosis in mammalian cells.
FOXO1 (Montrer FOXO1 Protéines), 3, and 4 as well as their upstream regulator, AKT/p-AKT (Montrer AKT1 Protéines), was examined in rhesus macaque ovaries of three developmental stages: fetal, prepubertal, and adult
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
forkhead box O3A
, forkhead box protein O3
, forkhead homolog (rhabdomyosarcoma) like 1
, forkhead in rhabdomyosarcoma-like 1
, forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1
, forkhead box O3a
, forkhead protein FKHR2
, forkhead box O3A transcription factor
, forkhead box O3
, forkhead box O protein
, forkhead box protein O3-like