Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher toutes les espèces
Afficher tous les synonymes
Sélectionnez vos espèces et l'application
anti-Human SMAD2 Anticorps:
anti-Mouse (Murine) SMAD2 Anticorps:
anti-Rat (Rattus) SMAD2 Anticorps:
Vous arrivez à notre recherche pré-filtrée.
Human Monoclonal SMAD2 Primary Antibody pour IF, IP - ABIN968106
Babu, Jeganathan, Baker, Wu, Kang-Decker, van Deursen: Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. dans The Journal of cell biology 2003
Show all 5 Pubmed References
Human Monoclonal SMAD2 Primary Antibody pour IF, IP - ABIN968105
Chen, Waters, Salmon, Murray: Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. dans Science (New York, N.Y.) 1996
Show all 5 Pubmed References
Human Polyclonal SMAD2 Primary Antibody pour WB - ABIN2801941
Liu, Pouponnot, Massagué: Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. dans Genes & development 1998
Show all 3 Pubmed References
Human Monoclonal SMAD2 Primary Antibody pour ICC, FACS - ABIN969401
Wendt, Smith, Schiemann: p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. dans The Journal of biological chemistry 2009
Show all 2 Pubmed References
Human Monoclonal SMAD2 Primary Antibody pour FACS, IF - ABIN967045
Hannan, Jamshidi, Pera, Wolvetang: BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures. dans Cloning and stem cells 2009
Show all 2 Pubmed References
Human Monoclonal SMAD2 Primary Antibody pour IF, IHC (p) - ABIN517619
Talvinen, Tuikkala, Nykänen, Nieminen, Anttinen, Nevalainen, Hurme, Kuopio, Kronqvist: Altered expression of p120catenin predicts poor outcome in invasive breast cancer. dans Journal of cancer research and clinical oncology 2010
Human Polyclonal SMAD2 Primary Antibody pour IHC (p), IHC - ABIN316295
Lee, Lee, Bae, Jung: Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. dans Histochemistry and cell biology 2013
Human Polyclonal SMAD2 Primary Antibody pour ELISA, WB - ABIN257079
Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. dans Cell 1996
Human Polyclonal SMAD2 Primary Antibody pour WB - ABIN362418
Kim, Jong, Kim, Lee, Kim, Hong, Bang: Transforming growth factor-beta 1 induces apoptosis through Fas ligand-independent activation of the Fas death pathway in human gastric SNU-620 carcinoma cells. dans Molecular biology of the cell 2004
Show all 2 Pubmed References
Human Polyclonal SMAD2 Primary Antibody pour WB - ABIN362416
Zhang, Shen, Zhang, Wan, Yao, Wu, Wang, Chen, Yan, Jiang: Induction of thoracic aortic remodeling by endothelial-specific deletion of microRNA-21 in mice. dans PLoS ONE 2013
Show all 2 Pubmed References
The non-Smad (Montrer SMAD1 Anticorps) JNK (Montrer MAPK8 Anticorps) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (Montrer SMAD1 Anticorps) pathway, and this nuclear movement is associated with Smad (Montrer SMAD1 Anticorps) signal transduction toward the nucleus.
The results of this study found that Bptf (Montrer BPTF Anticorps) and TGF-beta (Montrer TGFB1 Anticorps)/Smad2 mediate nucleosome remodeling to regulate wnt8a (Montrer WNT8A Anticorps) expression and hence neural posteriorization.
Smad2 and Eomesodermin (Montrer EOMES Anticorps) a (Eomesa (Montrer EOMES Anticorps)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (Montrer EOMES Anticorps) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
Nodal signaling through the Smad2/3 pathway up-regulated Slug, Snail (Montrer SNAI1 Anticorps) and c-Myc (Montrer MYC Anticorps) to induce EMT (Montrer ITK Anticorps), thereby promotingVasculogenic mimicry (VM) formation.
this study shows that EGF (Montrer EGF Anticorps) induces epithelial-mesenchymal transition through phospho-Smad2/3-Snail (Montrer SNAI1 Anticorps) signaling pathway in breast cancer cells
Multiple myeloma cells adapted to long-term exposure to hypoxia exhibit stem cell characteristics with TGF-beta (Montrer TGFB1 Anticorps)/Smad (Montrer SMAD1 Anticorps) pathway activation.
a novel heterozygous missense mutation (c.833C>T, p.A278V) in the SMAD2 gene in a family with early onset aortic aneurysms
Data suggest that oncogenic Y-box binding protein 1 (YB-1 (Montrer YBX1 Anticorps)) indirectly enhances transforming growth factor beta (TGFbeta (Montrer TGFB1 Anticorps)) signaling cascades via Sma (Montrer SMN1 Anticorps)/Mad related protein 2 (Smad2)phospho-activation and may represent a promising factor for future diagnosis and therapy of breast cancer.
Asiaticoside hindered the invasive growth of KFs (Montrer GDF6 Anticorps) by inhibiting the GDF-9 (Montrer GDF9 Anticorps)/MAPK (Montrer MAPK1 Anticorps)/Smad (Montrer SMAD1 Anticorps) pathway.
High Smad2 expression is associated with invasion and metastasis in pancreatic ductal adenocarcinoma.
Data indicate that miR (Montrer MLXIP Anticorps)-206 inhibits neuropilin-1 (NRP1 (Montrer NRP1 Anticorps)) and SMAD2 gene expression by directly binding to their 3'-UTRs.
Results show that members of the Activin (Montrer Actbeta Anticorps) branch of the TGFbeta (Montrer TGFB1 Anticorps) signaling pathway, namely Put and Smad2, are autonomously required for cell and tissue growth in the Drosophila larval salivary gland.
CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.
Grg4 (Montrer TLE4 Anticorps) occupancy at the Xnr1 (Montrer NODAL Anticorps) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 (Montrer TLE4 Anticorps) from FoxH1 (Montrer FOXH1 Anticorps) at the Xnr1 (Montrer NODAL Anticorps) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (Montrer TCF3 Anticorps) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (Montrer GDF11 Anticorps) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
Activin A (Montrer INHBA Anticorps) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (Montrer NANOG Anticorps) and OCT4 (Montrer POU5F1 Anticorps),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (Montrer NANOG Anticorps)/OCT4 (Montrer POU5F1 Anticorps) expression.
the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (Montrer TGFB1 Anticorps) signalling that incorporates elements of previous models together with crosstalking between Smad1 (Montrer SMAD1 Anticorps)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (Montrer SMAD7 Anticorps).
Results suggest that Smad2/3 linker threonine phosphorylation is expressed during acinar-ductal metaplasia.
NODAL/Activin (Montrer Actbeta Anticorps) signaling induces dramatic chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2, acting via multiple mechanisms.
Blocking Smad2/3 signaling in pluripotent stem cells results in epigenetic changes that enhance the capacity for endoderm differentiation.
cells expressing mutant huntingtin (Montrer HTT Anticorps) have a dysregulated transcriptional response to epidermal growth factor (Montrer EGF Anticorps) stimulation
Smad2- and Smad3 (Montrer SMAD3 Anticorps)-deficient bone marrow (BM) cells display reduced sensitivity to transforming growth factor-beta (TGFbeta (Montrer TGFB1 Anticorps)) inhibition.
Data (including data from studies using knockout mice) suggest Garp/Lrrc32 (Montrer LRRC32 Anticorps) is involved in up-regulation of Tgfb3 (Montrer TGFB3 Anticorps) and is essential for embryogenesis of palate; Garp (Montrer LRRC32 Anticorps) knockout causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Garp (Montrer LRRC32 Anticorps) = glycoprotein A repetitions predominant (Montrer LRRC32 Anticorps) protein; Tgfb3 (Montrer TGFB3 Anticorps) = transforming growth factor beta 3 (Montrer TGFB3 Anticorps))
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (Montrer TPM1 Anticorps), as a model of immature Leydig cells.
Lnc-LFAR1 binds directly to Smad2/3 and promotes transcription of TGFbeta (Montrer TGFB1 Anticorps), Smad2, Smad3 (Montrer SMAD3 Anticorps), Notch2 (Montrer NOTCH2 Anticorps) and Notch3 (Montrer NOTCH3 Anticorps) which, in turn, results in TGFbeta (Montrer TGFB1 Anticorps) and Notch (Montrer NOTCH1 Anticorps) pathway activation.
P311 (Montrer C5orf13 Anticorps) is a novel TGFbeta1 (Montrer TGFB1 Anticorps)/Smad (Montrer SMAD1 Anticorps) signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
the levels of Smad2/3, P-Smad2/3 expressions were decreased, while the level of Smad7 (Montrer SMAD7 Anticorps) expression was increased after treatment with osthole.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
SMAD, mothers against DPP homolog 2
, MAD (mothers against decapentaplegic, Drosophila) homolog 2
, SMA- and MAD-related protein 2
, SMAD 2
, SMAD family member 2
, mothers against DPP homolog 2
, mothers against decapentaplegic homolog 2
, MAD homolog 2
, Sma- and Mad-related protein 2
, mother against DPP homolog 2
, mothers against decapentaplegic-like 2
, Smad 2
, mad-related protein 2