Profil protéine

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

• SMAD family member 2 (SMAD2) anticorps
• SMAD family member 2-Z (SMAD2Z) anticorps
• SMAD family member 2 (smad2) anticorps
• SMAD family member 2 S homeolog (smad2.S) anticorps
• SMAD family member 2 (Smad2) anticorps

• 7120426M23Rik anticorps
• fj43c06 anticorps
• hmad-2 anticorps
• hsmad2 anticorps
• jv18 anticorps
• Afficher tous les alias de synonymes
• jv18-1 anticorps
• Madh2 anticorps
• MAD homolog 2 anticorps
• Madr2 anticorps
• mMad2 anticorps
• Mothers against DPP homolog 2 anticorps
• Smad-2 anticorps
• SMAD 2 anticorps
• Smad2 anticorps
• wu:fj43c06 anticorps
• Xmad2 anticorps
• XSmad2 anticorps

Protein level used designations for SMAD2

MAD homolog 2 , SMAD, mothers against DPP homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic homolog 2 , SMAD 2 , mothers against DPP homolog 2 , mothers against decapentaplegic-like 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD family member 2 , Smad 2 , mad-related protein 2 , LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 2