Use your antibodies-online credentials, if available.
Il n’y a pas de produits dans votre liste de comparaison.
Votre panier est vide.
Afficher toutes les espèces
Afficher tous les synonymes
Sélectionnez vos espèces et l'application
anti-Human Topoisomerase II alpha Anticorps:
anti-Mouse (Murine) Topoisomerase II alpha Anticorps:
anti-Rat (Rattus) Topoisomerase II alpha Anticorps:
Vous arrivez à notre recherche pré-filtrée.
Human Polyclonal Topoisomerase II alpha Primary Antibody pour ICC, IF - ABIN4361369
Lindén, Segersten, Runeson, Wester, Busch, Pettersson, Lind, Malmström: Tumour expression of bladder cancer-associated urinary proteins. dans BJU international 2013
Show all 2 Pubmed References
Arabidopsis thaliana Polyclonal Topoisomerase II alpha Primary Antibody pour IL, WB - ABIN334538
Xie, Lam: Abundance of nuclear DNA topoisomerase II is correlated with proliferation in Arabidopsis thaliana. dans Nucleic acids research 1995
Show all 2 Pubmed References
Human Monoclonal Topoisomerase II alpha Primary Antibody pour IF, IHC (p) - ABIN563224
Poonperm, Takata, Hamano, Matsuda, Uchiyama, Hiraoka, Fukui: Chromosome Scaffold is a Double-Stranded Assembly of Scaffold Proteins. dans Scientific reports 2015
Data show that comparing with Ki-67 (Montrer MKI67 Anticorps) and TOP2A, RacGAP1 (Montrer RACGAP1 Anticorps) allowed for a clearer prognostic statement.
These findings reveal a novel, p53 (Montrer TP53 Anticorps)-independent activity of Mdm2 (Montrer MDM2 Anticorps) and have important implications for the choice of chemotherapeutic agents in the treatment of Mdm2 (Montrer MDM2 Anticorps)-overexpressing tumors. Herein is shown that tumor cells with MDM2 (Montrer MDM2 Anticorps) amplification are selectively resistant to treatment with topoisomerase II (Montrer TOP2 Anticorps) poisons but not other DNA damaging agents
The methodology is useful for a high-throughput analysis of drugs that poison Top2, allowing not just the discrimination of the Top2 isoform that is targeted but also to track its removal
TOP2A was identified in association with the progression and prognosis of pancreatic ductal adenocarcinoma probably by regulating cell cycle and p53 (Montrer TP53 Anticorps) signaling pathway.
the relation between TOP2A levels and sensitivity for doxorubicin was examined, confirming reports that TOP2A mRNA levels were overexpressed in MPNST and showing that MPNST cell lines exhibited relatively high TOP2A protein levels and sensitivity to doxorubicin.
The decatenation checkpoint is regulated, not only by topo IIalpha, as previously reported, but also by topo IIbeta. The decatenation checkpoint is most efficient when both isoforms are present. Deletion of most of the C-terminus of topo IIalpha, while preserving the nuclear localization signal (NLS (Montrer ALDH1A2 Anticorps)), enhances the decatenation checkpoint and sensitivity to topo II (Montrer TOP2 Anticorps)-targeted drugs. Mutation of Y640 in topo IIalpha inhibi...
Tumors with higher topoisomerase IIalpha and/or mitosin (Montrer CENPF Anticorps) expression have a higher risk of recurrence after initial treatment, and these patients may benefit from adjuvant treatment and closer radiological follow-up
Both the genome instability and cell death of MRE11 (Montrer MRE11A Anticorps)-null and MRE11 (Montrer MRE11A Anticorps)-mutated H129N cells are significantly reversed by overexpression of Tdp2 (Montrer TDP2 Anticorps), an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 (Montrer MRE11A Anticorps) nuclease (Montrer DCLRE1C Anticorps) activity is likely to remove the DNA lesions.
we show that TopoIIalpha forms protein-protein interactions with beta-catentin and TCF4 (Montrer TCF4 Anticorps) and interacts with Wnt (Montrer WNT2 Anticorps) response elements (WREs) and promoters of direct target genes of TCF (Montrer HNF4A Anticorps) transcription, including: MYC (Montrer MYC Anticorps), vimentin (Montrer VIM Anticorps), AXIN2 (Montrer AXIN2 Anticorps) and LEF1 (Montrer LEF1 Anticorps)
This study shows that both survivin (Montrer BIRC5 Anticorps) and TIIalpha are independent prognostic predictors in human grade II/III astrocytomas stratified for IDH1 (Montrer IDH1 Anticorps)-mutation status
Polyamide functionalisation at the N1-position offers a design strategy to improve drug-like properties. Dicationic HxIP* 3 increased topo IIalpha expression and chemosensitivity to topo II (Montrer TOP2 Anticorps)-targeting agents.
TOP2 (Montrer TOP2 Anticorps) and BAF (Montrer BANF1 Anticorps) cooperate to recruit pluripotency factors, which explains some of the instructive roles of BAF (Montrer BANF1 Anticorps) complexes.
Deletion or deficiency of PTEN leads to down regulation of TOP2A, dysfunction of the decatenation checkpoint and incomplete DNA decatenation in G2 and M phases.
Inhibition of DNA topoisomerase II (Montrer TOP2 Anticorps) selectively reduces the threat of tumorigenicity
Cohesin removal is a prerequisite for the posterior topoisomerase IIalpha-mediated resolution of persisting catenations between segregating chromatids during anaphase II.
Data show that unfolded protein response (UPR)-induced changes in topoisomerase IIalpha (Topo IIalpha) protein levels are not responsible for resistance to etoposide, and that the PERK plays a Topo IIalpha-independent role in altered sensitivity to the drug.
Topoisomerase IIa not only contributes to stem-cell transcriptome regulation but also primes developmental genes for subsequent activation upon differentiation.
studies indicate that the ability of TOP2A to prevent DNA entanglement at mitosis requires BAF (Montrer BANF1 Anticorps) complexes and suggest that this activity contributes to the role of BAF (Montrer BANF1 Anticorps) subunits as tumour suppressors
our data reveal TDP2 (Montrer TDP2 Anticorps)-mediated error-free NHEJ as an efficient and accurate mechanism to repair TOP2 (Montrer TOP2 Anticorps)-induced DSBs
DNA topoisomerase II (Montrer TOP2 Anticorps) distribution in mouse preimplantation embryos
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
, DNA topoisomerase (ATP-hydrolyzing)
, DNA topoisomerase 2-alpha
, DNA topoisomerase II, 170 kD
, DNA topoisomerase II, alpha isozyme
, DNA Topoisomerase II alpha
, topoisomerase (DNA) 2 alpha
, DNA topoisomeraseII_alpha
, topoisomerase (DNA) II alpha
, Thimet metalloendopeptidase 2
, Zincin-like metalloproteases family protein 2