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anti-Rat (Rattus) TRPV1 Anticorps:
anti-Human TRPV1 Anticorps:
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Human Polyclonal TRPV1 Primary Antibody pour ICC, IF - ABIN250444
Guo, Vulchanova, Wang, Li, Elde: Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. dans The European journal of neuroscience 1999
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Mammalian Monoclonal TRPV1 Primary Antibody pour ISt, IHC - ABIN1305031
Mickle, Shepherd, Loo, Mohapatra: Induction of Thermal and Mechanical Hypersensitivity by Parathyroid Hormone-related Peptide (PTHrP) via Upregulation of TRPV1 Function and Trafficking. dans Pain 2015
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Rat (Rattus) Polyclonal TRPV1 Primary Antibody pour WB - ABIN549036
Kwon, Roh, Yoon, Moon, Choi, Choi, Kang, Han, Beitz, Oh, Lee: Acid evoked thermal hyperalgesia involves peripheral P2Y1 receptor mediated TRPV1 phosphorylation in a rodent model of thrombus induced ischemic pain. dans Molecular pain 2014
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Rat (Rattus) Polyclonal TRPV1 Primary Antibody pour IF, IHC - ABIN238891
Mukherjea, Jajoo, Sheehan, Kaur, Sheth, Bunch, Perro, Rybak, Ramkumar: NOX3 NADPH oxidase couples transient receptor potential vanilloid 1 to signal transducer and activator of transcription 1-mediated inflammation and hearing loss. dans Antioxidants & redox signaling 2011
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Human Polyclonal TRPV1 Primary Antibody pour IHC (p), WB - ABIN967211
Caterina, Schumacher, Tominaga, Rosen, Levine, Julius: The capsaicin receptor: a heat-activated ion channel in the pain pathway. dans Nature 1997
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Human Polyclonal TRPV1 Primary Antibody pour ICC, IHC (fro) - ABIN152470
Zsombok, Gao, Miyata, Issa, Derbenev et al.: Immunohistochemical localization of transient receptor potential vanilloid type 1 and insulin receptor substrate 2 and their co-localization with liver-related neurons in the hypothalamus and ... dans Brain research 2011
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Human Monoclonal TRPV1 Primary Antibody pour ELISA, WB - ABIN521348
Zheng, Zhang, Han, Sun, Zhou, Zhao, Wang: Nerve growth factor rescues diabetic mice heart after ischemia/reperfusion injury via up-regulation of the TRPV1 receptor. dans Journal of diabetes and its complications 2015
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Human Polyclonal TRPV1 Primary Antibody pour IF, IHC - ABIN267171
Karai, Brown, Mannes, Connelly, Brown, Gandal, Wellisch, Neubert, Olah, Iadarola: Deletion of vanilloid receptor 1-expressing primary afferent neurons for pain control. dans The Journal of clinical investigation 2004
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Human Monoclonal TRPV1 Primary Antibody pour ELISA, WB - ABIN563377
Choi, Park, Jo, Kang, Park, Kim, Hong, Kim, Lee, Yoon: Endogenous expression of TRPV1 channel in cultured human melanocytes. dans Journal of dermatological science 2009
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Mouse (Murine) Polyclonal TRPV1 Primary Antibody pour IHC - ABIN239041
Takashima, Ma, McKemy: The development of peripheral cold neural circuits based on TRPM8 expression. dans Neuroscience 2010
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Results demonstrate that cell motility and Ca(2+)i activity are affected by pharmacological agents that target TRPV1, indicating a novel role for this channel during cell migration.
Using knock-down studies, we also show that TRPV1 is required for normal heat-induced locomotion.
We haven't found any differences in cold sensation threshold between males and females in both phases of OMC. Moreover, we found significant gender and interphase differences in receptor protein TRPV1 level - the maximal level in females in luteal phase of the OMC, lower in males and minimal in females in follicular phase of the OMC
Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling.
Polymorphic variations of TRPV1 and (CALCA) genes play a role as prognostic markers of efficacy of OnabotulinumtoxinA in chronic migraine female patients.
This study demonstrated that the Expression of VR1 was highest in the intermediate zone, at the beginning and at the end of the investigated periods, pointing to VR1 spatial pattern in the visceral afferents in the grey matter, while the first signs of calretinin were found in the 9th-10th developmental weeks ventrally.
The expression of SP and TRPV1 in intervertebral disc tissues in patients with Degenerative Disc Disease was associated with NF-kappaB activation.
Study results indicate a key role for both inositol trisphosphate receptor and TRPV1 in Ca2+ internal stores in the PAR2-evoked Ca2+ release and consequent skin inflammation in differentiated human primary keratinocytes.
Modulation of IL-1beta release was not TRPV1 mediated.
Inhibitions of anandamide transport and FAAH synthesis decrease apoptosis and oxidative stress through inhibition of TRPV1 channel in an in vitro seizure model
These results suggest novel genetic susceptibility to primary localized provoked vulvodynia associated with specific alleles in genes TRPV1 and NGF and propose the rs222747 "C" allele of TRPV1 as a common genetic predisposition for other pain syndromes.
This study detected 6 single-nucleotide polymorphisms and 11 single-nucleotide polymorphisms related to burning pain and capsaicin sensitivity.
These findings indicate that Urban Particulate Matter upregulates expression of the TRPV 1 gene, which is mediated by the p38 mitogen-activated protein kinase (MAPK) and NF-kappaB signaling pathways.
Correlation between heat pain threshold and TRPV1 receptor protein level over various phases of the ovarian-menstrual cycle has been reported.
C-fibers and transient receptor potential cation channel, subfamily V, member 1 protein (TRPV 1)-mediated vasodilations are impaired in type 1 diabetes (T1D) patients.
Src kinase mediates UV-induced TRPV1 trafficking into cell membrane in HaCaT keratinocytes.
Disruption of the association of Sig-1R with TRPV1 by synthetic or natural antagonists leads to degradation of TRPV1 protein and to decreased levels of the ion channel protein as well as to a decrease in TRPV1-associated pain.
A strong capacity to positively regulate skin sensitization mechanisms related to the TRPV1 receptors.
Activation of TRPV1 channels attenuates ischemia-reperfusion-induced injury in a variety of organs including heart, kidney, lungs, and brain possibly via enhancing the discharge of calcitonin gene-related peptide and substance P
cystinosis patients homozygous for the 57-kb deletion exhibit a strong reduction of TRPV1 function, leading to sensory deficiencies akin to the phenotype of TRPV1-deficient mice
The TRPV1 mRNA were significantly upregulated in chronic Low Back Pain compared with controls.
antitumor and apoptosis effects of 5-FU are up-regulated by activation of TRPV1 channels, but its action was down-regulated by HPer treatment. It seems that HPer cannot be used for increasing the antitumor effect of 5-FU through modulation of the TRPV1.
By downregulating TRPV1 and P2Y receptors.
Transient receptor potential vanilloid 1 (TRPV1) channel as the receptor sensing tissue damage in the injured eye.
The therapeutic potential for TRPV1 agonism for stroke treatment.
sub-epithelial corneal nerve density and intraepithelial expression of transient receptor potential vanilloid receptor 1 (TRPV1) were significantly preserved with SM-345431. Our results suggest that inhibition of Sema3A may be an effective therapy for Dry eye disease (DED).
It is concluded that co-exposure to airborne particulate matter PM2.5 and formaldehyde exacerbated allergic asthma through oxidative stress and enhanced TRPV1 activation.
Comparative study of TRPV1 channels in mouse (mV1) and those in platypus (pV1), which naturally lacks heat-induced desensitization (Dh) show that a temperature-sensitive interaction between the N- and C-terminal domains of mV1 but not pV1 drives a conformational rearrangement in the pore leading to Dh. Findings suggest that Dh evolved late during evolution as a protective mechanism.
It has been proposed that in poorly controlled diabetes, the accelerated rate of capsaicin-sensitive TRPV1 current decay in dorsal root ganglion neurons decreases overall TRPV1 activity and contributes to peripheral neuropathy.
Results show that the transient receptor potential vanilloid family member 1 (TRPV1) cation channel plays a critical role mediating Ca(2+) influx in DRG axons withdrawn from NGF. We further demonstrate that TRPV1 activation is dependent on reactive oxygen species (ROS) generation that is driven through protein kinase C (PKC) and NADPH oxidase (NOX)-dependent pathways that become active upon NGF withdrawal.
These data demonstrate that SIRT1 directly inhibits osteoclastogenesis by inhibiting ROS generation and TRPV1 channel activation under mediation of TNF-alpha.
Results indicate that surgical incision activates the paraventricular hypothalamus and that Trpv1 and Trpv4 might be involved in neuronal activity in the dorsal horn laminae III-IV after surgical incision.
inhibition of TRPV1 by TRPV1 antagonist has significant anti-inflammatory effects on ozone-induced asthma exacerbation
Activation of temperature-sensitive TRPV1-like receptors in the arcuate nucleus of the hypothalamus neurons reduces food intake.
esults suggested that ALDH2 may rescue against doxorubicin cardiac toxicity possibly through a TRPV1-mediated protection of mitochondrial integrity.
TrpV1 receptor activation rescues neuronal function and network gamma oscillations from amyloid-beta-induced impairment in mouse hippocampus in vitro.
This is the first study to provide evidence that TDAG8, ASIC3 and TRPV1 regulate hyperalgesic priming of RA pain and that a transition from acute to chronic RA pain is at about 4 weeks.
CGRPalpha from within TRPV1-cre population plays an important role in visceral nociception but less so in somatic nociception.
Following unilateral acute inflammation of the knee, knee neurons have 1) a lower action-potential threshold 2) increased sensitivity to capsaicin and expression of TRPV1 and 3) an increasing trend in the magnitude of GABA-evoked currents up to 28-h in culture.
Association of TRPV1 and TLR4 through the interleukin-1 receptor domain potentiates TRPV1 activity by blocking activation-induced desensitization
Key markers of psoriatic inflammation and epidermal hyperplasia are reduced in TRPV1 KO mice, indicating the involvement of TRPV1 in the psoriasiform inflammation and suggesting its potential as a therapeutic target.
findings show the involvement of both TRPA1 and TRPV1 channels in trigeminal neuropathic pain, and in particular, in trigeminal mechanical allodynia.
This study is the first to shed light on the structural determinants required for the interaction between TRPV1 and evodiamine, and gives new suggestions for the rational design of novel TRPV1 ligands.
TRPV1 is expressed in cells that are particularly active in Ca(2) exchange as well as in cells with significant water transport activity in eyes of New Zealand White rabbits and humans
There is no correlation of expression of thromboxane A2 receptor with TRPV1 in dorsal root ganglia and nodose ganglia.
Activation of transient receptor potential vanilloid subtype 1 increases expression and permeability of tight junction in normal and hyposecretory submandibular gland
HCl-induced activation of TRPV1 causes ATP release from esophageal epithelial cells that causes release of CGRP and SP from esophageal submucosal neurons.
Capsaicin increased secretion and upregulated the expression of TRPV1 and AQP5 in transplanted submandibular glands.
qPCR showed that expression of TRPV1 and TRPA1 was positively correlated each other and significantly upregulated in lung tissues of model group compared with that of controls. Expression of TRPV1/TRPA1 was upregulated in the chronic cough related to bleomycin induced pulmonary fibrosis in guinea pigs, which provided new insights into the mechanism of idiopathic pulmonary fibrosis (IPF)-associated cough hypersensitivity.
The contractile effect of anandamide in the guinea-pig small intestine is mediated by prostanoids but not TRPV1 receptors or capsaicin-sensitive nerves.
Allergic airway inflammation can induce the expression of TRPV1 in tracheal A-fiber neurons.
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene.
, capsaicin receptor
, osm-9-like TRP channel 1
, transient receptor potential cation channel subfamily V member 1
, vanilloid receptor 1
, vanilloid receptor subtype 1
, vanilloid receptor type 1 like protein 1
, vanilloid type 1 receptor
, transient receptor potential vanilloid 1a
, transient receptor potential vanilloid 1b
, cation channel
, transient receptor potential cation channel V1
, transient receptor potential vanilloid type 1
, transient receptor potential V1
, vanilloid receptor-like protein