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anti-Rat (Rattus) LMO3 Anticorps:
anti-Mouse (Murine) LMO3 Anticorps:
anti-Human LMO3 Anticorps:
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suggested that the expression levels of Lmo3 and/or Hen2 (Montrer NHLH2 Anticorps) could determine the fate of stem cells by inhibiting Hes1 (Montrer HES1 Anticorps) function during nervous system development and might be a trigger of aberrant neurogenesis in vivo
These results support a role for LMO3 in regulating behavioral responses to ethanol, potentially through its actions in the nucleus accumbens.
Gbx2 (Montrer GBX2 Anticorps) regulates thalamocortical axon guidance by modifying the LIM (Montrer PDLIM5 Anticorps) and Robo codes.
when tested for behavioral responses to ethanol, transgenic mice exhibited altered ethanol sedation and consumption that correlated with Lmo3 expression levels; results suggest a role for Lmo3 in ethanol-related behaviors in mice
Results suggest that all four members of the LIM (Montrer PDLIM5 Anticorps)-only family -- LMO1 (Montrer LMO1 Anticorps), 2, 3, and 4 -- are important regulators of distinct developmental pathways.
Data show that the calcium- and integrin-binding protein CIB (Montrer CIB1 Anticorps) as an LMO3-binding protein, which binds via the second LIM (Montrer PDLIM5 Anticorps) domain (LIM2 (Montrer LHX2 Anticorps)) of LMO3.
SH3BP5 (Montrer SH3BP5 Anticorps), LMO3, and SNAP25 (Montrer SNAP25 Anticorps) were expressed in diffuse large B-cell lymphoma cells and associated with clinical features.
LMO3 attenuates GATA4 (Montrer GATA4 Anticorps)-dependent, BMP2 (Montrer BMP2 Anticorps)-mediated inflammatory endothelial activation.
MiR (Montrer MLXIP Anticorps)-101 decreased the expression of LMO3 by reversing the methylation status of the LMO3 promoter and by inhibiting the presence of the methylation-related histones H3K4me2 and H3K27me3 and increasing the presence of H3K9me3 and H4K20me3 on the promoter.
LMO3 as a regulator of human adipogenesis and could contribute a mechanism resulting in visceral-fat accumulation in obesity due to excess glucocorticoids.
suggest that LMO3 is a transcriptional signal transducer in NKX2-1 (Montrer NKX2-1 Anticorps)-amplified lung adenocarcinomas
We confirmed that the expression of LMO3 in squamous cell carcinoma is regulated by DNA methylation (Montrer HELLS Anticorps) of its specific promoter region.
The present results suggest that a transcriptional complex of LMO3 and HEN2 (Montrer NHLH2 Anticorps) may contribute to the genesis and malignant phenotype of neuroblastoma (Montrer ARHGEF16 Anticorps) by inhibiting HES1 (Montrer HES1 Anticorps) which suppresses the transactivation of Mash1 (Montrer ASCL1 Anticorps).
LMO3 acts as a co-repressor of p53 (Montrer TP53 Anticorps), suppressing p53 (Montrer TP53 Anticorps)-dependent transcriptional regulation without inhibition of its DNA-binding activity.
The deregulated expression of neuronal-specific LMO3 and HEN2 (Montrer NHLH2 Anticorps) contributes to the genesis and progression of human neuroblastoma (Montrer ARHGEF16 Anticorps) in a lineage-specific manner.
The protein encoded by this gene belongs to the rhombotin family of cysteine-rich LIM domain oncogenes. This gene is predominantly expressed in the brain. Related family members, LMO1 and LMO2 on chromosome 11, have been reported to be involved in chromosomal translocations in T-cell leukemia. Many alternatively spliced transcript variants have been found for this gene.
LIM domain only protein 3
, LIM domain only 3 (rhombotin-like 2)
, LIM domain only 3
, lim domain only protein 3
, neuronal-specific transcription factor DAT1
, dopamine-inducible LIM-domain transcription factor DAT1
, LIM only 3
, LIM domain only protein 1