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Data show that sustained expression of Lmx1a and Lmx1b (Montrer LMX1B Anticorps) is required for the survival of adult midbrain dopaminergic neurons.
Lmx1a and Lmx1b (Montrer LMX1B Anticorps) regulate Plxnc1 (Montrer PLXNC1 Anticorps) expression.Lmx1a is required for the topographical organization of dopaminergic innervation in the striatum.
Lmx1a is expressed in enterochromaffin cells and functions downstream of Nkx2.2 (Montrer Nkx2-2 Anticorps).
This study showed that spontaneous Lmx1a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
The data of this study that Oc-1 (Montrer ONECUT1 Anticorps) interacts with Lmx1a to promote ventral midbrain neural stem cells differentiation into dopamine neuron through Wnt1 (Montrer WNT1 Anticorps)-Lmx1a pathway.
Lmx1a signaling in mouse embryonic stem cells contributes to a molecular cascade establishing neuronal specification.
our data demonstrate that key midbrain dopamine regulators (Nurr1 (Montrer NR4A2 Anticorps), Pitx3 (Montrer PITX3 Anticorps), and Lmx1a) play overlapping as well as distinct roles during neurogenesis and neurotransmitter phenotype determination of mDA neurons
The data of this study suggested that aberrant anlage patterning and granule cell development lead to Purkinje cell ectopia, which ultimately causes abnormal cerebellar architecture in dreher.
dopamine transporter is a direct target of Lmx1a and emphasizes a novel role of Lmx1a as one of regulators of mature midbrain dopaminergic neurotransmitter phenotypes
Lmx1a mutant (dr/dr) embryos demonstrate a clear decrease in expression of the genes Grb10 (Montrer GRB10 Anticorps) and Rgs4 (Montrer RGS4 Anticorps).
Study revealed an anti-metastatic role of LMX1A in gastric cancer which is mediated by the negative regulation of beta-catenin (Montrer CTNNB1 Anticorps) signaling target genes.
Lmx1a and Lmx1b (Montrer LMX1B Anticorps) expression persists in mature dopaminergic neurons of the substantia nigra pars (Montrer EPRS Anticorps) compacta and the ventral tegmental area. [Review]
SNPs of the LMX1A gene might be associated with the susceptibility to congenital scoliosis and different clinical phenotypes in the Chinese Han population.
To our best knowledge, this is the first report demonstrating the application of TAT (Montrer TAT Anticorps)-LMX1A recombinant protein to enhance hESC differentiation to DA as shown by the expression of DA specific makers.
LMX1A is weakly methylated in cervical adenocarcinomas compared with controls, in a metastatic stage of cervical cancer.
these data imply that Sp1 (Montrer PSG1 Anticorps) and EZH2 (Montrer EZH2 Anticorps) may activate LMX1A expression upon oncogenic stress during cervical cancer development.
Higher immunostaining intensity for OPN (Montrer SPP1 Anticorps) and LMX1A correlated with WHO grades for meningiomas and some gliomas. Contrary to our expectations, LMX1A staining in WHO grade IV gliomas was shown to be weaker than in WHO grade III tumours.
The Lmx1a can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching.
One single nucleotide polymorphisms of lmx1a was strongly associated with the magnitude of training-related gains in verbal working memory
LMX1A may be a potential biomarker for gastric cancer.
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants.
LIM homeobox transcription factor 1-alpha
, LIM/homeobox protein 1.1
, LIM/homeobox protein LMX1A
, shaker short-tail