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anti-Mouse (Murine) LMX1A Anticorps:
anti-Rat (Rattus) LMX1A Anticorps:
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Human Polyclonal LMX1A Primary Antibody pour ELISA, WB - ABIN544031
Robertson, Charatsi, Joyner, Koonce, Morgan, Islam, Paterson, Lejsek, Arnold, Kallies, Nutt, Bikoff: Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. dans Development (Cambridge, England) 2007
Show all 2 Pubmed References
Data show that sustained expression of Lmx1a and Lmx1b is required for the survival of adult midbrain dopaminergic neurons.
Lmx1a and Lmx1b regulate Plxnc1 expression.Lmx1a is required for the topographical organization of dopaminergic innervation in the striatum.
Lmx1a is expressed in enterochromaffin cells and functions downstream of Nkx2.2.
This study showed that spontaneous Lmx1a mutations causing cerebellar pathology are impaired in motor functions during the neonatal period.
The data of this study that Oc-1 interacts with Lmx1a to promote ventral midbrain neural stem cells differentiation into dopamine neuron through Wnt1-Lmx1a pathway.
Lmx1a signaling in mouse embryonic stem cells contributes to a molecular cascade establishing neuronal specification.
our data demonstrate that key midbrain dopamine regulators (Nurr1, Pitx3, and Lmx1a) play overlapping as well as distinct roles during neurogenesis and neurotransmitter phenotype determination of mDA neurons
The data of this study suggested that aberrant anlage patterning and granule cell development lead to Purkinje cell ectopia, which ultimately causes abnormal cerebellar architecture in dreher.
dopamine transporter is a direct target of Lmx1a and emphasizes a novel role of Lmx1a as one of regulators of mature midbrain dopaminergic neurotransmitter phenotypes
Lmx1a mutant (dr/dr) embryos demonstrate a clear decrease in expression of the genes Grb10 and Rgs4.
The characterization of two new Lmx1a alleles highlights the critical role of this gene in the development of the cochlea and vestibular system.
Data conclude that Lmx1a is a useful marker for the extraction of progenitors of GABAergic or dopaminergic neurons.
The Lmx1a can induce desired neuronal lineages from most expressing neural progenitor cells by a mechanism resembling developmental binary cell-fate switching.
This study demonstrated that Lmx1a and Lmx1b function cooperatively to regulate proliferation, specification, and differentiation of mDA progenitors, including their floor plate-like properties.
data establish that Lmx1b influences the differentiation of multiple neuronal subtypes in the ventral midbrain, whereas Lmx1a appears to be exclusively devoted to the differentiation of the dopamine neuron lineage
Generation of knockout mice expressing a GFP-reporter under the control of the Lmx1a locus.
In the developing cerebellum, Lmx1a is expressed in the roof plate, where it is required to segregate the roof plate lineage from neuronal rhombic lip derivatives.
obtained evidence that Lmx1a and Lmx1b cooperate with Foxa2 to specify mesDA neuron identity by gain-of-function approaches using transgenic mice
Lmx1a/Lmx1b null mutant mice fail to generate a hindbrain roof plate. Both genes act in concert to direct normal hindbrain formation.
Lmx1a is expressed in the dorsal midline (roof plate) of the neural tube, the cortical hem, the otic vesicles, the developing cerebellum and the notochord of developing mice
The late-onset progressive phenotype and the absence of cochleovestibular malformations on computed tomography scans indicate that heterozygous defects of LMX1A do not result in severe developmental abnormalities in humans.
Study revealed an anti-metastatic role of LMX1A in gastric cancer which is mediated by the negative regulation of beta-catenin signaling target genes.
Polymorphisms of dopamine pathway gene aLMX1A is associated with cognitive performance in Bipolar disorder.
Lmx1a and Lmx1b expression persists in mature dopaminergic neurons of the substantia nigra pars compacta and the ventral tegmental area. [Review]
SNPs of the LMX1A gene might be associated with the susceptibility to congenital scoliosis and different clinical phenotypes in the Chinese Han population.
To our best knowledge, this is the first report demonstrating the application of TAT-LMX1A recombinant protein to enhance hESC differentiation to DA as shown by the expression of DA specific makers.
LMX1A is weakly methylated in cervical adenocarcinomas compared with controls, in a metastatic stage of cervical cancer.
higher expression is associated with more advanced neoplasm staging in Chinese patients with pancreatic ductal adenocarcinomas
these data imply that Sp1 and EZH2 may activate LMX1A expression upon oncogenic stress during cervical cancer development.
Higher immunostaining intensity for OPN and LMX1A correlated with WHO grades for meningiomas and some gliomas. Contrary to our expectations, LMX1A staining in WHO grade IV gliomas was shown to be weaker than in WHO grade III tumours.
One single nucleotide polymorphisms of lmx1a was strongly associated with the magnitude of training-related gains in verbal working memory
LMX1A may be a potential biomarker for gastric cancer.
Genetic variation in LMX1A may increase the risk of developing schizophrenia.
Did not find evidence for association of any LMX1A SNPs with type 2 diabetes mellitus (T2DM) and conclude that LMX1A does not contribute significantly to T2DM etiology in Pima Indians.
Lmx1a expression is necessary for the expression of bone morphogenetic protein (BMP), and for the normal generation and differentiation of the dorsal-most spinal cord neurons, the dl1 interneurons.
Lmx1a may be critical to the development of midbrain dopamine neurons from human embryonic stem cells.
Data show that three single nucleotide polymor in LMX1A and one in LMX1B are associated with Parkinson's disease.
This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants.
LIM homeobox transcription factor 1-alpha
, LIM/homeobox protein 1.1
, LIM/homeobox protein LMX1A
, shaker short-tail