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anti-Rat (Rattus) alpha Tubulin Anticorps:
anti-Human alpha Tubulin Anticorps:
anti-Mouse (Murine) alpha Tubulin Anticorps:
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Bird (Avian) Monoclonal alpha Tubulin Primary Antibody pour CyTOF, FACS - ABIN152113
Odreman, Vindigni, Gonzales, Niccolini, Candiano, Zanotti, Skrap, Pizzolitto, Stanta, Vindigni: Proteomic studies on low- and high-grade human brain astrocytomas. dans Journal of proteome research 2005
Show all 69 Pubmed References
All Species Monoclonal alpha Tubulin Primary Antibody pour ICC, IHC (p) - ABIN93891
Dráber, Dráberová, Linhartová, Viklický: Differences in the exposure of C- and N-terminal tubulin domains in cytoplasmic microtubules detected with domain-specific monoclonal antibodies. dans Journal of cell science 1990
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Human Polyclonal alpha Tubulin Primary Antibody pour ELISA, WB - ABIN129653
Hall, Cowan: Structural features and restricted expression of a human alpha-tubulin gene. dans Nucleic acids research 1985
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All Species Monoclonal alpha Tubulin Primary Antibody pour ICC, IHC (p) - ABIN93892
Dráber, Dráberová, Zicconi, Sellitto, Viklický, Cappuccinelli: Heterogeneity of microtubules recognized by monoclonal antibodies to alpha-tubulin. dans European journal of cell biology 1987
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All Species Monoclonal alpha Tubulin Primary Antibody pour ICC, IHC (p) - ABIN301997
Honys, R?nuak, Fecikovua, Jedelskuy, Nebesuarovua, Dobrev, Capkovua: Cytoskeleton-associated large RNP complexes in tobacco male gametophyte (EPPs) are associated with ribosomes and are involved in protein synthesis, processing, and localization. dans Journal of proteome research 2009
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Human Polyclonal alpha Tubulin Primary Antibody pour IF, IHC - ABIN6712205
Zhu, Shan, Wang, Shu, Liu: miR-181b modulates multidrug resistance by targeting BCL2 in human cancer cell lines. dans International journal of cancer 2010
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Chicken Polyclonal alpha Tubulin Primary Antibody pour ELISA, ICC - ABIN6269432
Qiu, Li, Kong, Li, Niu, Pan: Herbal SGR Formula Prevents Acute Ethanol-Induced Liver Steatosis via Inhibition of Lipogenesis and Enhancement Fatty Acid Oxidation in Mice. dans Evidence-based complementary and alternative medicine : eCAM 2015
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Pig (Porcine) Monoclonal alpha Tubulin Primary Antibody pour ELISA, WB - ABIN387714
Lakshmana, Hayes, Bennett, Bianchi, Reddy, Koo, Kang: Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
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Human Monoclonal alpha Tubulin Primary Antibody pour FM, IHC - ABIN964563
Patel, Blaauboer, Tucker, Mansouri, Ruiz-Moreno, Hamann, Schumann, Opitz, Jin: The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele. dans Journal of immunology (Baltimore, Md. : 1950) 2017
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Chicken Monoclonal alpha Tubulin Primary Antibody pour IHC (p), WB - ABIN3043083
Zuo, Liu, Zhang, Wu, Guo, Liao: Development of trastuzumab-resistant human gastric carcinoma cell lines and mechanisms of drug resistance. dans Scientific reports 2015
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Data show that retinal endothelial cells (HREC) treated with low molecular weight fraction of commercial 5% human serum albumin (LMWF5A) exhibit a rapid increase in the amount and distribution of acetylated alpha-tubulin.
The C-terminal tail from the tubulin beta I isotype, but not the beta III isotype, formed contacts in the putative binding site of a recently discovered antineoplastic peptide that disrupts microtubule formation in glioma cells.
TUBA1B/ESR1 gene interaction might play pivotal roles in the occurrence and development of Postmenopausal Osteoporosis.
Taken together our data provide valuable information regarding the interaction of CK1delta and a-tubulin and a novel approach for the development of pharmacological tools to inhibit proliferation of cancer cells.
Results suggest that lithium chloride (LiCl) treatments activate alpha-tubulin N-acetyltransferase 1 (alphaTAT1) by the inhibition of glycogen synthase kinase 3 beta (GSK-3beta) and promote the alpha-tubulin acetylation, and then elongate the primary cilia.
NAD-dependent regulation of alpha-tubulin acetylation is mediated by SIRT2.
Data indicate that the derivatives exhibited much better potency to inhibit tubulin polymerization but a decreased activity to inhibit Hsp27 chaperone function.
Increased TUBA1B expression is associated with poor overall survival in hepatocellular carcinoma.
ARHGAP21 is a Rho-GAP involved in cell-cell junction remodeling that affects migration and EMT through alpha-tubulin interaction and acetylation
TQ induced a concentration- and time-dependent degradation of alpha/beta tubulin in both cancer cell types.
the ethyl acetate extract of Lactuca sativa induced HL-60 cell death, which correlated with the acetylation of alpha-tubulin.
Confocal microscopic analyses showed co-localization of the TaSP protein with alpha-tubulin and reciprocal immuno-co-precipitation experiments demonstrated an association of TaSP with alpha-tubulin in vivo.
This protein has been found differentially expressed in the anterior cingulate cortex from patients with schizophrenia
Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp.
increased levels in paclitaxel-resistant breast cancer cells
Candidate gene K-ALPHA-1 expression in malignant and non-malignant prostate tissue samples after microdissection.
accumulation of alpha-synuclein might contribute to the pathogenesis of PD and other Lewy body diseases by promoting alterations in parkin and tubulin solubility
N-terminal sequencing and blastx analysis as well as blocking with K-alpha1 tubulin-specific Ab identified the epithelial Ag as K-alpha1 tubulin[K-alpha1 tubulin]
mitochondrial ribosomal protein S12 3'-UTR interacts specifically with TRAP1 (tumor necrosis factor receptor-associated protein1), hnRNPM4 (heterogeneous nuclear ribonucleoprotein M4), Hsp70 and Hsp60 (heat shock proteins 70 and 60), and alpha-tubulin
These results imply that MeCP2 is involved in the regulation of neuronal alpha-tubulin and add molecular evidence that reversal of the effects of MeCP2 deficiency is achievable
The molecular interaction between alpha-synuclein and tubulin was confirmed by GST pull-down assay and co-immunoprecipitation.
Study shows that loss of Tubb2a or Tubb2b does not impair survival but does lead to relatively mild cortical malformation phenotypes. In contrast, loss of Tuba1a is perinatal lethal and leads to significant forebrain dysmorphology. The ability of the mouse to survive in the absence of some tubulin genes known to cause disease in humans suggests future intervention strategies for these devastating tubulinopathy diseases.
In this study, we demonstrate that missense mutations affecting arginine at position 402 (R402) of TUBA1A alpha-tubulin selectively impair dynein motor activity and severely and dominantly disrupt cortical neuronal migration.
Transgenic mdx mice expressing the short dystrophin isoform Dp116 served as a negative control. All mini- and micro-dystrophins restored elevated detyrosinated alpha-tubulin and microtubule density of mdx muscle to values not different from C57BL/10, however, only mini-dystrophins restored the transverse component of the microtubule lattice back to C57BL/10.
Here the authors demonstrate that mice lacking the alpha-tubulin acetyltransferase Atat1 in sensory neurons display profound deficits in their ability to detect mechanical stimuli.
Collectively, these findings suggest that Smo and primary cilia-dependent noncanonical Hh signaling leads to post-translational regulation of microtubules and may be important for modulating cell behaviors.
Further PS treatment resulted in recovery of axonal outgrowth and enhanced retrograde axonal transport by decreasing histone deacetylase 6 (HDAC6) levels and thus increasing acetylation of alpha-tubulin levels. Thus, we have identified the molecular pathway that leads to neurodegeneration in FD and have demonstrated that phosphatidylserine treatment has the potential to slow progression of neurodegeneration
mass spectrometry-based quantitative comparison of acetylated peptides from wild-type vs HDAC6 knockout mice allowed to identify six new deacetylation sites possibly mediated by HDAC6.
These results give new insights into the functions of Tuba1a, mechanisms for regulating tubulin proteostasis, and how compromising these may lead to neural defects.
Data indicate that alpha 1a tubulin (Tuba1a) showed the least variability in expression among the different stages of lung development.
Tubulin-tyrosine ligase (TTL) is required to increase the levels of tyrosinated alpha-tubulin at the axon injury site and plays an important role in injury signaling.
Data suggest a mechanistic link between tubulin hyperacetylation and autophagy induction.
TFIIB co-localizes and interacts with alpha-tubulin during oocyte meiosis in the mouse and depletion of TFIIB causes arrest of subsequent embryo development.
Acetylation of alpha-tubulin is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2) and HDAC6 (histone deacetylase 6). Adipocyte development is inhibited in MEC-17-knockdown cells, but enhanced in MEC-17-overexpressing cells.
Unambiguous identification of novel glutamylation sites E441 and E443 in mouse brain Tuba1a and Tuba1b.
This study demonistrated that novel tubal(aspartic acid to glycine) mutant mouse is a novel animal model for neurodevelopmental disorders.
These results demonstrate a role for CCP1 in the processing of Glu residues from beta- as well as alpha-tubulin in vitro and in vivo.
Our results highlight the importance of Tuba1a for correct neuronal migration
association between dysferlin and alpha-tubulin, as well as between dysferlin and microtubules
mice harbouring an S140G mutation in Tuba1a present with normal neurogenic potential, but that this neurogenesis is often ectopic
Data indicated that CacyBP/SIP could simultaneously interact with tubulin and actin, suggesting that CacyBP/SIP might link actin and tubulin cytoskeletons.
These results suggest that tuba1a-expressing progenitors contribute to multiple cell lineages during development and that tuba1a-expressing Muller glia are retinal progenitors in the adult.
These results suggest tuba1a expression is necessary for CNS development and regeneration and that KLF6a and 7a mediate their effects, at least in part, via transcriptional control of tuba1a promoter activity.
Wild-type 1.696 kb & mutant promoters w/o E-box &/or HD sequences had similar activity in developing retina. In mature retina, mutant promoter activity was less. E-box & HD sequences were needed during optic nerve regeneration, but not for retinal injury.
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
, tubulin alpha-1 chain
, tubulin alpha-1A chain
, tubulin, alpha 1
, alpha tubulin
, alpha-tubulin ubiquitous
, tubulin K-alpha-1
, tubulin alpha-1B chain
, tubulin alpha-ubiquitous chain
, tubulin, alpha, ubiquitous
, Talpha1 alpha-tubulin
, alpha-tubulin isotype M-alpha-1
, tubulin alpha-1C chain
, Alpha-tubulin 1
, Alpha-tubulin I
, Tubulin alpha-1 chain
, Tubulin alpha-1A chain
, alpha-tubulin I