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anti-Mouse (Murine) ROCK1 Anticorps:
anti-Rat (Rattus) ROCK1 Anticorps:
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Dog (Canine) Monoclonal ROCK1 Primary Antibody pour ICC, IF - ABIN252549
Zhao, Miller, Pfeiffer, Buras, Stahl: Anoxia and reoxygenation of human endothelial cells decrease ceramide glucosyltransferase expression and activates caspases. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003
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Human Polyclonal ROCK1 Primary Antibody pour ICC, IF - ABIN152055
Chang, Xie, Shah, Schneider, Entman, Wei, Schwartz: Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. dans Proceedings of the National Academy of Sciences of the United States of America 2006
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Human Polyclonal ROCK1 Primary Antibody pour IF (p), IHC (p) - ABIN707771
Wang, Zhang, Wang, Zhang, Mao, Zhuang, Tang, Luo, Zhou, Zhang: Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway. dans The international journal of biochemistry & cell biology 2013
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Human Monoclonal ROCK1 Primary Antibody pour IF, ELISA - ABIN562671
Gong, Fang, Peng, Liu, Du: Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors. dans Journal of biotechnology 2010
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Human Monoclonal ROCK1 Primary Antibody pour ELISA, WB - ABIN969563
Kroll, Epting, Kern, Dietz, Feng, Hammes, Wieland, Augustin: Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. dans American journal of physiology. Heart and circulatory physiology 2009
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Human Polyclonal ROCK1 Primary Antibody pour IF (p), IHC (p) - ABIN738636
Pan, Lu, Tang, Pan, Wan, Lan, Zhang, Sun: RAB8A GTPase regulates spindle migration and Golgi apparatus distribution via ROCK-mediated actin assembly in mouse oocyte meiosis†. dans Biology of reproduction 2019
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Human Monoclonal ROCK1 Primary Antibody pour WB - ABIN223244
Dasgupta, Argaiz, Mercado, Maul, Garza, Enriquez, Abdel-Monem, Prakasam, Andreeff, Thiagarajan: Platelet senescence and phosphatidylserine exposure. dans Transfusion 2010
polarity-induced spatiotemporal control of Rok and Pkn is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.
Loss of DRok function in tendon cells results in mis-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous junction formation and muscle morphogenesis.
model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 homolog Knittrig in controlling macrophage migration
Atonal and EGFR signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
The structure of Shrm domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm function, is reported.
Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.
CD44 interaction with p115RhoGEF and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3-kinase membrane localization, AKT signaling, and cytokine (M-CSF) production during HA-mediated breast cancer progression
Drok and Drosophila Lim-kinase interact in the developing nervous system
DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis
activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
In parallel to regulation of crb RNA and protein, Rho1 activity also signals through Rho-kinase (Rok) to induce apical constriction and cell shape change during invagination of salivary gland.
findings establish a ROCK1/AMPK signaling axis that regulates de novo lipogenesis, providing a unique target for treating obesity-related metabolic disorders such as NAFLD.
Toll-like receptor signaling in macrophages is regulated by extracellular substrate stiffness and Rho-associated coiled-coil kinase (ROCK1/2)
ROCK1- or ROCK2-haploinsufficient mice were protected from bleomycin-induced pulmonary fibrosis.
Study shows Increased apical and basal dendritic length and intersections were observed in rho-associated protein kinases 1 (ROCK1 +/-) but not rho-associated protein kinases 2 (ROCK2 +/-) mice. Observations implicate ROCK1 as a novel regulatory factor of neuronal dendritic structure and detail distinct and complementary roles of ROCKs in medial prefrontal cortex dendritic spine structure.
Chondroitin sulfate-impaired cell migration in vitro by activating ROCK.
These findings elucidated the molecular mechanism of anti-freezing, involving RhoA phosphorylation, meditated by the Rho/ROCK signalling pathway, in hatched and diapaused murine blastocysts.
by differentially affecting CyPA and Bsg expressions, ROCK1 protects and ROCK2 jeopardizes the heart from pressure-overload heart failure with postcapillary pulmonary hypertension, for which celastrol may be a promising agent.
Data indicate that Rho-associated protein kinase (ROCK)-dependent intermittent T cell migration regulates tissue-sampling during acute lung injury.
findings are the first to show that astrocytes exposed to MeHg showed increased cleavage/activation of ROCK-1, which was independent of the small GTPase RhoA
the transcription of Rho-associated coiled-coil containing protein kinase 1 (ROCK1), which phosphorylates Drp1 at Ser616, was shown by luciferase assay to be directly regulated by FOXO1. These findings suggested that FOXO1 is critical to preserve mitochondrial quantity and function in ECs, and FOXO1 may serve as a therapeutic target for microvascular complications of diabetes.
A specific inhibitor of ROCK, Y-27632, was used to examine the role of ROCK in mouse colitis models. ROCK1 and ROCK2 were silenced respectively using RNA interference in Caco-2 cells. The expression of tight junction proteins and the downstream molecules of ROCK were assessed
GTP-RhoA and ROCK1 expression levels were markedly increased in a time-dependent manner in the ears and lungs of mice treated with penicillin.
Irisin replenishment in mCaROCK1 mice partially reversed insulin resistance.
MicroRNA-146a suppresses ROCK1 allowing hyperphosphorylation of tau in Alzheimer's disease
Fasudil exhibited protective effects on smoke exposure induced cognitive deficits which might involve with the regulation of Rho/ROCK/NF-kappaB pathways.
we define how ROCK/LIMK pathway regulates mast cell development and functions
Dexamethasone up-regulates ROCK1/2 activity promoting migration, invasion and metastasis of melanoma cells.
mDia induces circumferential actin filaments around the edge of the synaptic cleft, which contract the presynaptic terminals in a ROCK-dependent manner.
SNRK in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2, which influenced Ras Homology Family Member A (RhoA) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (Dvl2).
STAT3 phosphorylation, while responsive to exogenous ligands on both soft and stiff matrices, is innately active on a stiff matrix in a ligand/receptor-independent, but ROCK- and JAK2-dependent fashion.
Rock inhibition-mediated alteration of senescent cell morphology may be associated with the decreased actin stress fibers formation. Since it is known that secretory activity is accompanied by the changes of cell morphology, these morphological alterations observed by the inhibition of Rho/Rho kinase pathway may also lead to important secretory functions of senescent cells.
Loss of protective endothelial CLOCK expression aggravates TGF-beta/ROCK1-modulated endothelial to mesenchymal transition progression, which contributes to the vulnerability of human carotid plaque.
ROCK1 and ROCK2 regulated cell proliferation in PC-3 and DU145 prostate cancer cells. Protein levels of phosphorylated LIM kinase 1 (p-LIMK1) and matrix metalloproteinase-2 (MMP-2) were reduced in ROCK1 and ROCK2 siRNA transfected cells. CONCLUSIONS In PC-3 and DU145 human prostate cancer cells, ROCK promoted cell proliferation and migration by targeting LIMK1 and MMP-2.
High ROCK1 expression is associated with adenomyosis.
we found that ROCK2 but not ROCK1 controls LPA-induced monocytic migration and monocyte adhesion toward endothelial cells. These findings demonstrate that ROCK2 is a key regulator of endothelial inflammation. We conclude that targeting endothelial ROCK2 is potentially effective in attenuation of atherosclerosis
MiR-144 inhibited tumor growth and metastasis in OS via dual-suppressing of RhoA and ROCK1.
These results demonstrate the importance of the FAM40 proteins for endothelial cell physiology, and suggest that they act as part of the CCM3-containing STRIPAK complex.
the lncRNA SNHG1 acted as an oncogene in OS cancer; it downregulated the expression of miRNA-101-3p and promoted cancer cell proliferation, migration and invasion through activating the expression of ROCK1, the PI3K/AKT pathway and EMT.
Long non-coding RNA LINC-ITGB1 can promote the proliferation, migration, and invasion of hepatocellular carcinoma cells by up-regulating ROCK1.
expression level of ROCK1 gene in acute lymphoblastic leukemia patients is high
Increased Rho kinase activity is associated with heart ischemia/reperfusion.
these findings indicate that miR-199a acts as a tumour suppressor and its downregulation in tumour tissues may contribute to the progression and metastasis of Renal cell carcinoma (RCC) through a mechanism involving ROCK1, suggesting miR-199a as a potential new diagnostic and therapeutic target for the treatment of RCC.
Rock1 has an important role in Rac1 regulation of actomyosin at the cell cortex.
We examined effects of induced mosaic knockdown of molecular regulators of cortical tension (ROCK1) and cell-cell adhesion (CDH1) with CRISPR interference. Mosaic knockdown of ROCK1 or CDH1 resulted in differential patterning within hiPSC colonies due to cellular self-organization, while retaining an epithelial pluripotent phenotype
Melatonin reduced ROCK1 and ROCK2 expression and activity in TGF-beta2-stimulated Glomerular Endothelial Cells by enhancing expression of miR-497, which targets ROCK1 and ROCK2.
SNHG5 acts as an oncogene in osteosarcoma via the SNHG5-miR-26a-ROCK1 axis.
upregulation of NEAT1 may promote proliferation, migration and invasion of gastric cancer cells via targeting miR-335-5p/ROCK1 axis
These results indicate shear stress induced vascular smooth muscle cell contraction was mediated by cell surface glycocalyx via a ROCK-MLC phosphatase (MLCP) pathway, providing evidence of the glycocalyx mechanotransduction in myogenic response.
he phosphorylation of the MP inhibitory MYPT1(T850) and the regulatory PRMT5(T80) residues as well as the symmetric dimethylation of H2A/4 were elevated in human hepatocellular carcinoma and in other types of cancers.
These results reveal a crucial role of ROCK-controlled directional cell movements during rabbit primitive streak formation.
Results indicate that ROCK1 and ROCK2 may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.
results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK/cofilin pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.
In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.
p38 phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
The RhoA/ROCK signaling pathway is an important negative regulator of vascular calcification.
These results suggest the existence of a feedback loop between cytoskeletal tension, adhesion maturation, and ROCK signaling that likely contributes to numerous mechanochemical processes.[ROCK]
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa vasorum endothelial cells, is reported.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Rho-associated coiled coil containing protein kinase 1
, rho-associated protein kinase 1
, Rho-associated, coiled-coil containing protein kinase 1
, Rho-associated kinase
, RhoA kinase
, drosophila rho-associated kinase
, rho kinase
, Rho-associated coiled-coil forming kinase 1
, p160 ROCK-1
, rho-associated, coiled-coil-containing protein kinase 1
, rho-associated, coiled-coil-containing protein kinase I
, Rho-associated kinase beta
, liver regeneration-related protein LRRG199
, p150 RhoA-binding kinase ROK beta
, Rho kinase
, renal carcinoma antigen NY-REN-35
, cAMP-dependent protein kinase ROCK-I
, corneal epithelial Rho-associated-Ser/Thr kinase 1
, Rho-kinase beta
, Rho-associated protein kinase 1
, rho-associated coiled-coil domain-containing protein kinase 1