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Human TUBB Protein expressed in Escherichia coli (E. coli) - ABIN2127108
Liu, Deng, Yan, Cheng, Luo, Li, Yin, Qin: Novel Beta-Tubulin-Immobilized Nanoparticles Affinity Material for Screening β-Tubulin Inhibitors from a Complex Mixture. dans ACS applied materials & interfaces 2017
Human TUBB Protein expressed in HEK-293 Cells - ABIN2734558
Chang, Zhao, Wang, Chen, Yan: Screening citrullinated proteins in synovial tissues of rheumatoid arthritis using 2-dimensional western blotting. dans The Journal of rheumatology 2013
human tumor cells can acquire spontaneous mutations in beta1-tubulin that cause resistance to paclitaxel
Roles of tubulin beta 1,3 residues Ala428 and Thr429 in microtubule formation in vivo.
TUBB exon 4 mutations and mismatch repair defects do not play a significant role in paclitaxel/cisplatin resistance
Mutations in either TUBB or MAPRE2 cause circumferential skin creases Kunze type.
the dipole moments of each tubulin isotype may influence their functional characteristics within the cell, resulting in differences for MT assembly kinetics and stability
Leucine point mutations viz. L215H, L217R, and L225M were reported for paclitaxel resistance in various cancers. In the current study, molecular mechanism of these resistance causing mutations in TUBB1 was explored using molecular docking, molecular dynamics simulation, binding energy estimation, free energy decomposition, principle component analysis and free energy landscape methods.
Data suggest a looser binding of the ligand in tubulin mutants.
Data show that tubulin phosphorylation and acetylation play important roles in the control of microtubule assembly and stability.
Data suggest that, while lacking a stable structure, NFL-TBS.40-63 peptide (a peptide derived from light neurofilament protein) preferentially binds on a specific single site located near C-terminal end of beta-tubulin.
Citrullination of TUBB is associated with neoplasms.
mechanism of binding and stabilization of microtubules in mammalian cells can be effectively modeled in yeast and also having the advantage of lacking any beta-tubulin isotypes that can complicate interpretation of experiments in mammalian cells.
Data indicate that leucine-rich repeat kinase 2 (LRRK2) selectively interacts with three beta-tubulin isoforms: TUBB, TUBB4, and TUBB6.
Studies suggest that tubulin-interactive agents have the potential to play a significant role in the fight against cancer.
Centaurin-alpha interacts with beta-tubulin and stabilizes microtubules.
results provide insight into the functional repertoire of the tubulin gene family, specifically implicating TUBB5 in embryonic neurogenesis and microcephaly
TQ induced a concentration- and time-dependent degradation of alpha/beta tubulin in both cancer cell types.
Allele frequencies between a group of 191 ITP patients & controls showed no direct aetiological role for SNP (R307H), but it was associated with immunomodulatory treatment failure.
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Data show that knockdown of S100P led to downregulation of thioredoxin 1 and beta-tubulin and upregulation of RhoGDIA, all potential therapeutic targets in cancer.
This is the first cell-based evidence to support a beta-tubulin-binding site for peloruside A and laulimalide.
The axial elastic modulus of tubulin diminishes as the length of the monomer increases.
The results suggest that betaTub97EF upregulation at low temperature contributes to acclimation by stabilizing microtubules.
The model of molecular folding for the mRNP particle involving the mRNA of beta-tubulin 56D has been proposed.
Our results indicate that the maternally supplied beta1-Tubulin based microtubule network is sufficient for myoblast fusion, myotube elongation and sarcomere formation both during visceral and somatic muscle development in Drosophila embryogenesis
Codepletion of Vhl with Mgr gives partial rescue of tubulin instability, monopolar spindle formation, and loss of centrosomes.
These data reveal that beta2-tubulin has robust properties for axoneme assembly, and that axonemal specializations are embedded in both the C-terminal tail and the body of the beta2 molecule.
Bagpipe and Biniou serve as direct, partially redundant, and tissue-specific activators of the terminal differentiation gene beta 3Tub60D in the visceral mesoderm
Partially truncated beta2-tubulin (beta2Delta7) containing only the proximal portion of the C-terminal tail, including the axoneme motif, can support production of functional motile sperm.
beta2t plays an important role in salivary gland and myoblast migration
beta 5-tubulin\; polymerizes to form microtubules\; member of a family of structural proteins
, beta Ib tubulin
, beta-4 tubulin
, class I beta-tubulin
, tubulin beta chain
, tubulin beta polypeptide
, tubulin beta-1 chain
, tubulin beta-5 chain
, tubulin, beta polypeptide
, putative cobalt-zinc-cadmium outer membrane resistance protein
, Tubulin, Beta family member (tbb-6)
, tubb beta-5
, tubulin beta-1
, tubulin, beta, 5
, tubulin, beta 2A
, tubulin, beta class I
, tubulin beta-2B chain
, tubulin, beta 2B class IIb
, c(beta)7 tubulin
, tubulin beta 4'
, tubulin beta-7 chain
, tubulin, beta 2
, tubulin, beta 2A class IIa
, beta tubulin
, beta-1 tubulin
, beta-Tubulin at 56 D
, beta-tubulin 56D
, beta1 tubulin
, tubulin beta1-chain
, 60C beta tubulin
, b-3 tubulin
, b3 tubulin
, beta 3 tubulin
, beta-3 tubulin
, beta-Tubulin at 60A
, beta-tubulin 60D
, beta3 tubulin
, tubulin b-3
, b2 tubulin
, beta 2 tubulin
, beta2 tubulin
, testis-specific beta-tubulin
, beta4 tubulin
, tubulin, beta 5
, Class I beta-tubulin
, Tubulin beta-7 chain
, beta-tubulin isotype I
, class I beta tubulin