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These data will serve as a foundation for further insight into the cattle ADCY2 gene.
This study demonistrated that adcy2 knockout mice regulate the expression soluble adenylyl cyclase in brain.
Show that adenylyl cyclases 2 and 5 can form a functional heterodimeric complex in HEK293 cells and mouse myocardium.
In patients receiving capecitabine monotherapy, rs4702484, located in ADCY2 and close to MTRR, was associated with slightly reduced PFS for homozygous wild-type patients (CC 6.2 vs. CT 8.0 months; P=0.018).
Our present study defines an AC2 cAMP signaling compartment that specifically regulates IL-6 expression in bronchial smooth muscle cells.
AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex.
AGS3 reduced D(2L)DR-mediated sensitization of AC1 and AC2.
A replication of association between two SNPs previously associated with COPD (CHRNA3/5 and IREB2), as well as an association with COPD of one locus initially associated with lung function (ADCY2).
Data suggest that SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are potential prognostic markers in colorectal cancer.
AC2 and AC4 isoforms, stimulated by GTP binding protein betagamma subunits, are expressed in bronchial nonlipid raft membrane fractions where they colocalize with and couple to prostanoid EP2 receptors.
AC2 interacts with RXFP1 through AKAP79, whereas the association with PDE4D3 and PKA depends upon beta-arrestin 2 binding to Ser704.
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.
adenylate cyclase 2
, adenylate cyclase 2 (brain)
, adenylate cyclase type 2
, adenylate cyclase type 2-like
, ATP pyrophosphate-lyase 2
, adenylate cyclase type II
, adenylyl cyclase 2
, 3',5'-cyclic AMP synthetase
, adenylate cyclase II
, type II adenylate cyclase
, mutant adenylate cyclase 2