Aperçu des produits pour anti-ADCY5 (ADCY5) Anticorps

Human Adenylate Cyclase 5 (ADCY5) interaction partners

1. Mutations in ADCY5 are responsible for a hyperkinetic movement disorder that can be preceded by episodic attacks before the movement disorder becomes persistent and is frequently misdiagnosed as dyskinetic cerebral palsy.

2. In this series of five ADCY5 mutation carriers, perioral twitches and truncal jerks do not represent myokymia

3. ADCY5-related dyskinesia may manifest variable expressivity within a single family, and affected individuals may be initially diagnosed with differing neurological phenotypes.

4. ADCY5 gene mutations can present with a wider variety of movement disorder syndromes.

5. ADCY5, which encodes adenylyl cyclase type 5, and RAP2C (Montrer RAP2C Anticorps), which encodes a member of the RAS oncogene (Montrer RAB1A Anticorps) family, had associations of nearly genomewide significance. ADCY5 locus have been reported to be associated with birth weight and type 2 diabetes however, none were in linkage disequilibrium with the SNPs showing significant association with gestational duration.

6. These data suggest that rs11708067-A risk allele contributes to type 2 diabetes by disrupting an islet enhancer, which results in reduced ADCY5 expression and impaired insulin (Montrer INS Anticorps) secretion.

7. This study demonstrated that whole-exome sequencing show reveled ADCY5 mutation with early-onset generalized dystonia.

8. the clinical spectrum of ADCY5 mutations encompasses paroxysmal weakness in addition to paroxysmal dyskinesia and persistent hyperkinesia, nominating ADCY5 mutations as a genetic cause of unexplained alternating hemiplegia of childhood.

9. This study showed that ADCY5 mutation carriers display pleiotropic paroxysmal day and nighttime dyskinesias.(

10. Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A (Montrer ADRA2A Anticorps), CDKAL1 (Montrer CDKAL1 Anticorps), CDKN2A/B, GRB10 (Montrer GRB10 Anticorps), and TCF7L2 (Montrer TCF7L2 Anticorps)

Mouse (Murine) Adenylate Cyclase 5 (ADCY5) interaction partners

1. AC5 knockout mice, without exercise training, share similar mechanisms responsible for enhanced exercise capacity with chronic exercise training.

2. Adenylyl cyclase 5 links changes in calcium homeostasis to cAMP-dependent cyst growth in a model of autosomal dominant polycystic liver disease.

3. Epac1 (Montrer RAPGEF3 Anticorps) is involved in AC5-mediated catecholamine stress-induced cardiac fibrosis. Epac1 (Montrer RAPGEF3 Anticorps) is involved in AC5-mediated elongation of atrial fibrillation.

4. In this study, we report that in the striatum AC5 exists in a stable pre-coupled complex with subunits of Golf heterotrimer.

5. changes in adipose tissue ADCY5 expression are related to obesity and fat distribution.

6. these results suggest that AnxA4 (Montrer ANXA4 Anticorps) is a novel direct negative regulator of AC5, adding a new facet to the functions of annexins.

7. These results identify the AC5 and mGluR system in the dorsal striatum as molecular on/off switches to direct decisions on behavioral preferences for cue-oriented options

8. deficiency of AC5 protects against obesity, glucose intolerance, and insulin (Montrer INS Anticorps) resistance.

9. Myocardial adrenergic receptor beta 1 (Montrer ADRB1 Anticorps) preferentially associates with AC5.

10. Disruption of AC5 prevents cardiomyopathy induced by chronically enhanced beta-AR signaling in mice with overexpressed beta-AR, potentially by enhancing resistance to oxidative stress and apoptosis, suggesting a novel, alternative approach to beta-AR blockade.

Pig (Porcine) Adenylate Cyclase 5 (ADCY5) interaction partners

1. Describe developmental expression of adenylyl cyclase 5.

Rabbit Adenylate Cyclase 5 (ADCY5) interaction partners

1. our data suggest that AC5 is the prevalent adenylyl cyclase isoform in rabbit renal cortex