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anti-Human PIK3C2A Anticorps:
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Human Polyclonal PIK3C2A Primary Antibody pour ELISA, WB - ABIN544164
Brown, Domin, Arcaro, Waterfield, Shepherd: Insulin activates the alpha isoform of class II phosphoinositide 3-kinase. dans The Journal of biological chemistry 1999
Show all 3 Pubmed References
Human Polyclonal PIK3C2A Primary Antibody pour IHC (p), IHC - ABIN268603
Molz, Chen, Hirano, Williams: Cpk is a novel class of Drosophila PtdIns 3-kinase containing a C2 domain. dans The Journal of biological chemistry 1996
Human Polyclonal PIK3C2A Primary Antibody pour ELISA - ABIN562223
Arbuckle, Komiyama, Delaney, Coba, Garry, Rosie, Allchorne, Forsyth, Bence, Carlisle, ODell, Mitchell, Fleetwood-Walker, Grant: The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. dans EMBO reports 2010
Human Monoclonal PIK3C2A Primary Antibody pour IHC, WB - ABIN2728930
Gulluni, Martini, De Santis, Campa, Ghigo, Margaria, Ciraolo, Franco, Ala, Annaratone, Disalvatore, Bertalot, Viale, Noatynska, Compagno, Sigismund, Montemurro, Thelen, Fan, Meraldi, Marchiò, Pece et al.: Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function. ... dans Cancer cell 2017
The level of PIK3C2A gene expression in patients with acute myocardial infarction is significantly lower than that of healthy people.
PIK3C2A Polymorphism is associated with recurrence in non-small cell lung cancer.
Four gene signature (PTEN, PIK3C2A, ITPA and BCL3) is an independent prognostic factors of both overall survival and disease-free survival in clear-cell renal-cell carcinoma.
These results elucidated that PIK3C2A mRNA acts as a miR-124 decoy to regulate CD151 and to affect hepatocellular carcinoma malignant phenotypes.
PIK3C2A was associated with bipolar disorder.
Results present evidence that PI3K-C2alpha is critical in the proper maturation of endosomes, and for coordinating the use of endosomes as an additional membrane source during autophagy.
miR-518a-5p was downregulated in imatinib-resistant gastrointestinal stromal tumors (GISTs), and the expression of miR-518a-5p was confirmed with good concordance between real-time PCR and miRNA microarray results. Luciferase reporter assays indicated that miR-518a-5p bound to the PIK3C2A 3'UTR.
Therefore, PI3K-C2A is a factor important for human cytomegalovirus replication and has a role in the production of human cytomegalovirus virions.
PI3KC2a knockdown results in rerouting of insulin signaling and pancreatic beta cell proliferation.
MiR-206 regulates endothelial progenitor cell activities by targeting PIK3C2alpha expression.The role of PIK3C2alpha in endothelial progenitor cell function in coronary artery disease
PI3KC2alpha has a role in regulating shear-dependent platelet adhesion via regulation of membrane structure, rather than acute signalling
a model of S. flexneri dissemination is proposed in which the formation of vacuole-like protrusions is mediated by the PIK3C2A-dependent production of the signaling lipid phosphatidylinositol 3-phosphate in the protrusion membrane
Data (including data from knockout mice) suggest that PI3KC2a participates in tumor angiogenesis. [REVIEW]
These observations indicate that PI3K-C2alpha plays the pivotal role in TGFbeta receptor endocytosis and thereby Smad2/3 signaling, participating in angiogenic actions of TGFbeta.
Class II enzyme PI3K-C2beta and the class IB isozyme p110gamma mainly regulate the S1P- and high density lipoprotein (HDL)-dependent endothelial cell (EC) migration and PI3K-C2alpha primarily controls EC survival
PI3K-C2alpha plays the crucial role in S1P(1) internalization into the intracellular vesicular compartment, Rac1 activation on endosomes, and thereby migration through regulating vesicular trafficking in ECs
These data suggest a general role for PI3KC2alpha in regulating physiologically relevant dynamin-independent internalization pathways.
Phosphoinositide 3-kinase C2alpha was found to be differentially regulated by alpha(v)beta(3) and alpha(v)beta(5) integrin, and may represent a new regulatory pathway of cell migration downstream of integrin engagement.
Nickel compounds induce HIF-1 transactivation and Cap43 protein expression through a PI-3K/Akt-dependent and p70(S6k)- independent pathway.
VEGFR1 and VEGFR2 initiate a clonogenic response in myeloid leukemia cells that is PI3-kinase dependent.
This is how other pik3c2a SCR map but I think more specific mapping may be appropriate (Class II Phosphatidylinositol 3-Kinases).
This study adds to this divergence by indicating a nonredundant role for PI3KC2alpha, with no role for PI3KC2beta, in regulating platelet OCS structure and overall platelet-dependent thrombus stability.
Heterozygous PI3K-C2-alpha inactivation in platelets led to reduction in phosphatidylinositol 3-monophosphate and a mislocalization of several membrane skeleton proteins known to control the interactions between the plasma membrane and cytoskeleton.
Data (including data from knockout mice) suggest that Pi3kc2a participates in tumor angiogenesis. [REVIEW]
Our studies indicate that while Vps34 is the main PI3P source during autophagy, class II PI3Ks also significantly contribute to PI3P generation and regulate AP biogenesis.
PI3K-C2alpha has a crucial role in vascular formation and barrier integrity
PI3KC2alpha-deficient mice developed chronic renal failure and exhibited a range of kidney lesions, including glomerular crescent formation and renal tubule defects in early disease, which progressed to diffuse mesangial sclerosis.
phosphoinositide 3-kinase C2alpha has a role in insulin signaling
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
C2-containing phosphatidylinositol kinase
, phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha
, phosphoinositide 3-kinase-C2-alpha
, phosphoinositide-3-kinase, class 2, alpha polypeptide
, ptdIns-3-kinase C2 subunit alpha
, phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide
, phosphoinositide-3-kinase, class 2 alpha polypeptide
, Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing alpha polypeptide
, LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha