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anti-Human SPRY1 Anticorps:
anti-Rat (Rattus) SPRY1 Anticorps:
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Human Monoclonal SPRY1 Primary Antibody pour IHC (p), ELISA - ABIN564437
Moghaddam, Amini, Wei, Pourgholami, Morris: Initial report on differential expression of sprouty proteins 1 and 2 in human epithelial ovarian cancer cell lines. dans Journal of oncology 2012
Show all 2 Pubmed References
Human Polyclonal SPRY1 Primary Antibody pour ELISA, WB - ABIN564436
Mekkawy, De Bock, Lin, Morris, Wang, Pourgholami: Novel protein interactors of urokinase-type plasminogen activator receptor. dans Biochemical and biophysical research communications 2010
Human Polyclonal SPRY1 Primary Antibody pour ELISA, IHC - ABIN4355747
Hanafusa, Torii, Yasunaga, Matsumoto, Nishida: Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. dans The Journal of biological chemistry 2004
Inhibition of miR (Montrer MLXIP Anticorps)-29b could attenuate atherosclerosis by inhibiting the SPRY1/MAPK (Montrer MAPK1 Anticorps) signaling pathway and inflammation in aorta.
During adipogenesis and osteogenesis, TNF-alpha (Montrer TNF Anticorps) significantly increased Spry1 levels and overexpression of miR (Montrer MLXIP Anticorps)-21 dramatically decreased Spry1 levels in the presence of TNF-alpha (Montrer TNF Anticorps), indicated important roles of miR (Montrer MLXIP Anticorps)-21 in modulating link between TNF-alpha (Montrer TNF Anticorps) and Spry1. Our findings introduce a molecular mechanism in which TNF-alpha (Montrer TNF Anticorps) suppresses adipogenic and osteogenic differentiation of PDLSCs by inhibiting miR (Montrer MLXIP Anticorps)-21/Spry1 func...
Although the expression of SPRY1 was low when compared with other tumors, SPRY1 was variably expressed in primary Ewing sarcoma tumors and higher expression levels were significantly associated with improved outcome in a large patient cohort.
SPRY1 and SPRY2 (Montrer SPRY2 Anticorps) mRNA transcripts were significantly upregulated in human CRC (Montrer CALR Anticorps). Suppression of SPRY2 (Montrer SPRY2 Anticorps) repressed AKT2 (Montrer AKT2 Anticorps) and EMT (Montrer ITK Anticorps)-inducing transcription factors and significantly increased E-cadherin (Montrer CDH1 Anticorps) expression. Concurrent downregulation of SPRY1 and SPRY2 (Montrer SPRY2 Anticorps) also increased E-cadherin (Montrer CDH1 Anticorps) and suppressed mesenchymal markers in colon cancer cells.
Spry1 plays a selective role in at least a subset of triple-negative breast cancer to promote the malignant phenotype via enhancing EGF (Montrer EGF Anticorps)-mediated mesenchymal phenotype.
Suppression of SPRY1 by age-associated methylation inhibits the replenishment of the muscle stem cell pool.
Cosuppression of Sprouty and Sprouty-related negative regulators of FGF signalling in prostate cancer
There is an inverse correlation between the expression of Spry1 and growth, proliferation, invasion and migration of ovarian cancer cells.
A random population of LNCaP prostate cancer cells comprises a heterogeneous group of cells with different androgen-deprivation sensitivities and potential for invasiveness; expression levels of 2 genes known to be regulated by miR (Montrer MLXIP Anticorps)-21, an androgen-regulated microRNA, SPRY1 and JAG1 (Montrer JAG1 Anticorps) were lower in an androgen insensitive clone, than an androgen sensitive clone.
The Spry1 acts as a sensor of mitogenic activity that not only attenuates RTK signaling but also induces a cellular senescence response to avoid uncontrolled proliferation.
The results show that lnc-Spry1 could act as an early mediator of TGF-beta (Montrer TGFB1 Anticorps) signaling and reveal different roles for a long noncoding RNA in modulating transcriptional and posttranscriptional gene expression.
modulation of stromal paracrine signaling and extracellular matrix remodeling by SPRY1 regulates mammary epithelial morphogenesis during postnatal development.
Here, we present a novel mouse model of pheochromocytoma consisting of double-heterozygous mice for Pten and Sprouty1 (Spry1), which leads to pheochromocytomas that appear at earlier onset and grow at a higher rate than those from Pten+/- mice.
Sprouty gain of function disrupts lens cellular processes and growth by restricting receptor tyrosine kinase (Montrer ERBB3 Anticorps) signaling.
In vivo analysis of thyroid glands from Spry1 knockout mice reveals that Spry1 induces a senescence-associated secretory phenotype via activation of the NFkappaB pathway.
showed that hSpry1 overexpression prevents VEGF (Montrer VEGFA Anticorps) secretion
Spry1 and Spry2 (Montrer SPRY2 Anticorps) coordination is required for normal development of the external genitalia in mice
conjunctival epithelial Spry1 and Spry2 (Montrer SPRY2 Anticorps) redundantly promote eyelid closure.
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
protein sprouty homolog 1
, sprouty, Drosophila, homolog of, 1 (antagonist of FGF signaling)
, sprouty 1 protein
, sprouty homolog 1, antagonist of FGF signaling (Drosophila)
, sprouty homolog 1, antagonist of FGF signaling
, sprouty 1
, sprouty homolog 1a, antagonist of FGF signaling
, sprouty homolog 1b, antagonist of FGF signaling
, inhibitor of receptor tyrosine kinases