Aperçu des produits pour anti-TGFB1 (TGFB1) Anticorps

Human Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. This review analyzes the molecular mechanisms leading to TGFbeta dysregulation in tumor and stroma cells and the modification of the microenvironment that fosters colorectal cancer metastasis. [review]

2. theses results suggest that TGF-beta1 genotypes of recipient are the most associated with the risk of complications after haematopoietic stem cell transplantation

3. Studies indicate that transforming growth factor-beta (TGF-beta) signaling and receptor tyrosine kin (Montrer KIN Anticorps) (RTK) pathways interact with each other and their interplay is important for cancer development [Review].

4. We found that PD-L1 (Montrer CD274 Anticorps) expression was upregulated following TGF-beta induction; in contrast, it was downregulated by TGF-beta receptor-kinase inhibitors and the MET process. Furthermore, chemo-treatment increased TGF-beta expression and enhances PD-L1 (Montrer CD274 Anticorps) expression via autocrine TGF-beta induced EMT (Montrer ITK Anticorps). Analysis of clinical samples revealed a significant relationship between PD-L1 (Montrer CD274 Anticorps) expression and EMT (Montrer ITK Anticorps) status

5. TGF-beta1 promotes cells invasion and migration by inducing epithelial mesenchymal transformation in oral squamous cell carcinoma

6. Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population.

7. TGF-beta1 efficiently converted human acinar cells to duct-like cells (AD) in a SMAD (Montrer SMAD1 Anticorps)-dependent manner, highlighting fundamental differences between the species

8. Plasma kallikrein (Montrer KLKB1 Anticorps) (PLK (Montrer PLK1 Anticorps))-dependent transforming growth factor-beta (TGF-beta) activation could be detected in isolated pancreatic stellate cells (PSCs) from chronic pancreatitis (CP) and pancreatic cancer.

9. rs1800469 in TGFB1 was associated to hepatic decompensation in chronic hepatitis C, while the other 11 described polymorphisms must be evaluated in a larger cohort to determine the possible role of vitamin D in hepatitis C.

10. isatuximab decreases multiple myeloma cell- and bone marrow stromal cell-induced iTreg by inhibiting both cell-cell contact and TGFbeta/IL10. Finally, CD38 levels correlate with differential inhibition by isatuximab of Tregs from multiple myeloma versus normal donors.Targeting CD38 by isatuximab can preferentially block immunosuppressive Tregs and thereby restore immune effector function against multiple myeloma

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 stimulated lubricin (Montrer PRG4 Anticorps) secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin (Montrer PRG4 Anticorps) much higher compared with twice-a-week treatment.

2. hypoxia increased the expression of platelet-derived growth factor (PDGF (Montrer PDGFA Anticorps)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (Montrer MME Anticorps)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.

3. TGF-beta1 modulates the expression of syndecan-4 (Montrer SDC4 Anticorps) in cultured vascular endothelial cells in a biphasic manner.

4. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (Montrer FGF2 Anticorps) expression through the activation of AP-1 (Montrer JUN Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) in bovine mammary gland fibroblasts.

5. The results identify TGFB1 and ESRRA (Montrer ESRRA Anticorps) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

6. the combined treatment with TGF-beta1 and BMP-7 (Montrer BMP7 Anticorps) or treatment first with TGF-beta1 followed by BMP-7 (Montrer BMP7 Anticorps) was more effective than other treatment groups in both chondrogenic differentiation and SZP (Montrer PRG4 Anticorps) secretion.

7. Tenascin-X (Montrer TNXB Anticorps) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

8. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (Montrer SMAD1 Anticorps)/5/8 and Smad2 (Montrer SMAD2 Anticorps)/3 channels through a negative feedback loop dependent on Smad7 (Montrer SMAD7 Anticorps).

9. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Rabbit Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (Montrer SMAD3 Anticorps) signaling pathway in chronic heart failure .

2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

3. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (Montrer NFKB1 Anticorps), and the amelioration of disc degradation.

4. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (Montrer ROCK1 Anticorps) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

5. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

6. Smad7 (Montrer SMAD7 Anticorps) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (Montrer NOTCH1 Anticorps) signaling target in limbal epithelial stem cells.

7. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

8. After NOTCH1 (Montrer NOTCH1 Anticorps) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (Montrer Vcan Anticorps) and collagen II.

9. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF beta is involved in the pathogenesis of tympanosclerosis.

2. There was significantly higher expression of TGF-beta1 and MMP-9 (Montrer MMP9 Anticorps) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 regulated pAKT (Montrer AKT1 Anticorps) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

2. SIV infection of rhesus macaques results in the emergence of IL-17 (Montrer IL17A Anticorps)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (Montrer IL18 Anticorps) expression.

3. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (Montrer CD8A Anticorps)+ T cells from mesentric lymph nodes.

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 is activated or inactivated by MMP20 or KLK4 (Montrer KLK4 Anticorps) and that the amelogenin (Montrer AMELX Anticorps) cleavage product is necessary for the in-solution mobility of TGF-beta1.

2. Activated TGF-beta signaling rescued miR (Montrer MYLIP Anticorps)-143-reduced FSHR (Montrer FSHR Anticorps) and intracellular signaling molecules, and miR (Montrer MYLIP Anticorps)-143-induced porcine granulosa cell apoptosis.

3. TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (Montrer PTK2 Anticorps)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (Montrer PTK2 Anticorps) signaling is inhibited.

4. this study shows that TGF-beta1 protects intestinal integrity and influences Smad (Montrer SMAD1 Anticorps) and MAPK (Montrer MAPK1 Anticorps) signal pathways in intestinal epithelium cells after TNF-alpha (Montrer TNF Anticorps) challenge

5. this study shows that anemonin may ameliorate LPS (Montrer IRF6 Anticorps)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (Montrer EGFR Anticorps) signaling pathways

6. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

7. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

8. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (Montrer IL10 Anticorps), and IL-6 (Montrer IL6 Anticorps) in ovarian follicles are reported.

9. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (Montrer TGFB2 Anticorps) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

10. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (Montrer MAPK14 Anticorps) signaling, reduces CFTR (Montrer CFTR Anticorps) expression to impair CFTR (Montrer CFTR Anticorps)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (Montrer CFTR Anticorps) mutations and ultimately would compromise male fertility.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (Montrer SYCP3 Anticorps) serves as a vegetally enriched, intrinsic factor (Montrer GIF Anticorps) to ensure a prepared status of Smads for their activation.

3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (Montrer SMAD4 Anticorps)

6. sortilin (Montrer SORT1 Anticorps) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Within the limitations of the study design, production of COMP (Montrer COMP Anticorps) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. IL 6 (Montrer IL6 Anticorps) and TGF beta perform essential role in cerebral malaria pathogenesis by modulating the level of glial cell induced neuroinflammation.

2. The increased susceptibility to IMQ-induced psoriasis of GILZ (Montrer TSC22D3 Anticorps)-Tg mice was significantly associated with skin-specific over-activation of TGF-beta1-mediated signaling via SMAD2 (Montrer SMAD2 Anticorps)/3.

3. The data suggest that B cells can down-regulate the function of antigen-presenting cells, and in turn encephalitogenic Th1 (Montrer HAND1 Anticorps)/Th17 responses, via TGF-beta1.

4. p-SMAD2 (Montrer SMAD2 Anticorps)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF (Montrer CTGF Anticorps) exp p-SMAD2 (Montrer SMAD2 Anticorps)/3 and p-ERK1/2 might play a regulatory role in TGF-beta1 induced CTGF (Montrer CTGF Anticorps) expression during tooth development.

5. inhibiting NCAM1 (Montrer NCAM1 Anticorps) would be cardioprotective, counteract the pathological action of TGFbeta1 and reduce heart failure severity.

6. TGF-beta signaling has a role in inhibiting tumor progression and invasion in an induced mouse bladder cancer model

7. calpains inhibition plays crucial roles in vascular restenosis by preventing neointimal hyperplasia at the early stage via suppression of the MMP2 (Montrer MMP2 Anticorps)/TGF-beta1 pathway.

8. Suggest an essential role for platelet-derived TGFbeta1 for the vascular remodelling response to arterial injury, apparently independent from the role of platelets in thrombosis or haemostasis.

9. In cultured B16 melanoma and Bend3 endothelial cells treated with Bend3 conditioned media, MITF (Montrer MITF Anticorps), tyrosinase (Montrer TYR Anticorps), and melanin expression decreased due to TGFB1 secreted by the endothelial cells.

10. Lycat (Montrer LCLAT1 Anticorps) regulates TGF-beta mediated lung fibroblast differentiation in pulmonary fibrosis.

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...

2. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (Montrer LDB2 Anticorps).

3. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (Montrer SMAD5 Anticorps) mediated pathway.

4. PCSK7 (Montrer PCSK7 Anticorps) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

5. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

6. TGFbeta1 plays a role in zebrafish keratocyte migration.

7. data presented show that Zili (Montrer PIWIL2 Anticorps) suppresses TGF-beta signaling by physically associating with Smad4 (Montrer SMAD4 Anticorps) and preventing the formation of Smad2 (Montrer SMAD2 Anticorps)/3/4 and Smad1 (Montrer SMAD1 Anticorps)/5/9/4 complexes

8. TGF-beta1 acts at multiple sites, including LH receptor (Montrer LHCGR Anticorps), 20beta-HSD (Montrer HAL Anticorps) and membrane progestin receptor-beta (Montrer PAQR8 Anticorps), to inhibit zebrafish oocyte maturation

9. These data suggest Pez (Montrer PTPN14 Anticorps) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

10. Data show that Rock2 (Montrer ROCK2 Anticorps) acts as a negative regulator of the TGFbeta signaling pathway.