Aperçu des produits pour anti-TGFB1 (TGFB1) Anticorps

Human Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Following Schistosoma exposure, TSP-1 (Montrer THBS1 Anticorps) levels in the lung increase, via recruitment of circulating monocytes, while TSP-1 (Montrer THBS1 Anticorps) inhibition or knockout bone marrow prevents TGF-beta activation and protects against pulmonary hypertension development.

2. TGFbeta1 reduced complex IV protein MTCO1 (Montrer COX1 Anticorps) abundance in both myoblasts and myotubes.

3. TGF-beta1 expression is regulated by PlncRNA-1 in breast cancer.

4. Elevated AhR (Montrer AHR Anticorps) expression may be involved in the progression of tissue remodeling in chronic rhinosinusitis without nasal polyp without allergic rhinitis similar to TGF-beta1 expression

5. Overall, these findings suggest a more dominant role for SMAD3 (Montrer SMAD3 Anticorps) and SMAD4 (Montrer SMAD4 Anticorps) than SMAD2 (Montrer SMAD2 Anticorps) in TGFbeta-induced chondrogenesis of human bone marrow-derived mesenchymal stem cells.

6. High TGF beta expression is associated with Chronic Periodontitis.

7. Fewer TIMP-2 (Montrer TIMP2 Anticorps), Hsp70 (Montrer HSP70 Anticorps) and TGF-beta1 immunoreactive cells in younger individuals and increased expression of Hsp70 (Montrer HSP70 Anticorps) in elderly individuals demonstrated the influence of aging in lung remodeling

8. Data show that TGFbeta1-mediated EMT (Montrer ITK Anticorps) involves CD44 (Montrer CD44 Anticorps) splice isoform switching in ovarian cancer cells.

9. Gene silencing experiments of MLL4 (Montrer MLL2 Anticorps) and the subunits PA1 (Montrer PAGR1 Anticorps) and PTIP (Montrer PAXIP1 Anticorps) confirm TGF-beta-specific genes to be regulated by the MLL4 (Montrer MLL2 Anticorps) complex, which links TGF-beta signaling to transcription regulation by the MLL4 (Montrer MLL2 Anticorps) methyltransferase complex.

10. TGF-beta1 is significantly overexpressed in tumor tissue samples of clear cell Renal cell carcinoma (Montrer MOK Anticorps) patients. TGF-beta1 up-regulation could be responsible for the high levels of NNMT (Montrer NNMT Anticorps) observed in clear cell Renal cell carcinoma (Montrer MOK Anticorps) tissues.

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 stimulated lubricin (Montrer PRG4 Anticorps) secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin (Montrer PRG4 Anticorps) much higher compared with twice-a-week treatment.

2. hypoxia increased the expression of platelet-derived growth factor (PDGF (Montrer PDGFA Anticorps)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (Montrer MME Anticorps)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.

3. TGF-beta1 modulates the expression of syndecan-4 (Montrer SDC4 Anticorps) in cultured vascular endothelial cells in a biphasic manner.

4. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (Montrer FGF2 Anticorps) expression through the activation of AP-1 (Montrer JUN Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) in bovine mammary gland fibroblasts.

5. The results identify TGFB1 and ESRRA (Montrer ESRRA Anticorps) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

6. the combined treatment with TGF-beta1 and BMP-7 (Montrer BMP7 Anticorps) or treatment first with TGF-beta1 followed by BMP-7 (Montrer BMP7 Anticorps) was more effective than other treatment groups in both chondrogenic differentiation and SZP (Montrer PRG4 Anticorps) secretion.

7. Tenascin-X (Montrer TNXB Anticorps) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

8. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (Montrer SMAD1 Anticorps)/5/8 and Smad2 (Montrer SMAD2 Anticorps)/3 channels through a negative feedback loop dependent on Smad7 (Montrer SMAD7 Anticorps).

9. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Rabbit Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (Montrer SMAD3 Anticorps) signaling pathway in chronic heart failure .

2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

3. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (Montrer NFKB1 Anticorps), and the amelioration of disc degradation.

4. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (Montrer ROCK1 Anticorps) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

5. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

6. Smad7 (Montrer SMAD7 Anticorps) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (Montrer NOTCH1 Anticorps) signaling target in limbal epithelial stem cells.

7. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

8. After NOTCH1 (Montrer NOTCH1 Anticorps) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (Montrer Vcan Anticorps) and collagen II.

9. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF beta is involved in the pathogenesis of tympanosclerosis.

2. There was significantly higher expression of TGF-beta1 and MMP-9 (Montrer MMP9 Anticorps) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 regulated pAKT (Montrer AKT1 Anticorps) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

2. SIV infection of rhesus macaques results in the emergence of IL-17 (Montrer IL17A Anticorps)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (Montrer IL18 Anticorps) expression.

3. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (Montrer CD8A Anticorps)+ T cells from mesentric lymph nodes.

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 is activated or inactivated by MMP20 or KLK4 (Montrer KLK4 Anticorps) and that the amelogenin (Montrer AMELX Anticorps) cleavage product is necessary for the in-solution mobility of TGF-beta1.

2. Activated TGF-beta signaling rescued miR (Montrer MYLIP Anticorps)-143-reduced FSHR (Montrer FSHR Anticorps) and intracellular signaling molecules, and miR (Montrer MYLIP Anticorps)-143-induced porcine granulosa cell apoptosis.

3. TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (Montrer PTK2 Anticorps)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (Montrer PTK2 Anticorps) signaling is inhibited.

4. this study shows that TGF-beta1 protects intestinal integrity and influences Smad (Montrer SMAD1 Anticorps) and MAPK (Montrer MAPK1 Anticorps) signal pathways in intestinal epithelium cells after TNF-alpha (Montrer TNF Anticorps) challenge

5. this study shows that anemonin may ameliorate LPS (Montrer IRF6 Anticorps)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (Montrer EGFR Anticorps) signaling pathways

6. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

7. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

8. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (Montrer IL10 Anticorps), and IL-6 (Montrer IL6 Anticorps) in ovarian follicles are reported.

9. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (Montrer TGFB2 Anticorps) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

10. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (Montrer MAPK14 Anticorps) signaling, reduces CFTR (Montrer CFTR Anticorps) expression to impair CFTR (Montrer CFTR Anticorps)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (Montrer CFTR Anticorps) mutations and ultimately would compromise male fertility.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (Montrer SYCP3 Anticorps) serves as a vegetally enriched, intrinsic factor (Montrer GIF Anticorps) to ensure a prepared status of Smads for their activation.

3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (Montrer SMAD4 Anticorps)

6. sortilin (Montrer SORT1 Anticorps) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Within the limitations of the study design, production of COMP (Montrer COMP Anticorps) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Following Schistosoma exposure, TSP-1 (Montrer GZMA Anticorps) levels in the lung increase, via recruitment of circulating monocytes, while TSP-1 (Montrer GZMA Anticorps) inhibition or knockout bone marrow prevents TGF-beta activation and protects against pulmonary hypertension development.

2. TGF-beta/Smad (Montrer SMAD1 Anticorps) proteins signaling affects radiation response and prolongs survival by regulating DNA repair genes in malignant glioma.

3. The results indicate that EGFR (Montrer EGFR Anticorps) and its activation are critical for YAP (Montrer YAP1 Anticorps)-mediated suppression of TGF-beta1-induced apoptosis. This study provides a new understanding of the regulatory mechanism underlying the determination of cell fate in response to TGF-beta1-mediated simultaneous apoptosis and epithelial mesenchymal transformation.

4. transforming growth factor beta (TGFbeta) signaling was upregulated in HSCs from bone marrow of mice with MLL (Montrer MLL Anticorps)-AF9 (Montrer MLLT3 Anticorps)-induced acute myeloid leukemia (Montrer BCL11A Anticorps) (AML (Montrer RUNX1 Anticorps)) because of excessive production of TGFbeta1, especially from megakaryocytes, and overactivation of latent TGFbeta1 protein.

5. TGF-beta release from platelets is necessary for podoplanin (Montrer PDPN Anticorps)-mediated tumor invasion and metastasis in lung cancer.

6. Data suggest partial or complete transforming growth factor beta 1 (TGFBI) knockdown as a potential therapy against TGFBI-linked corneal dystrophies.

7. De novo formation of the biliary system by TGFbeta-mediated hepatocyte transdifferentiation

8. CXCL9 (Montrer CXCL9 Anticorps) may promote prostate cancer progression via inhibition of cytokines from T cells.

9. EGCG attenuated airway inflammation in asthmatic mice, decreased the percentage of Th17 cells and increased the percentage of Treg cells. The antiinflammatory effect of EGCG is achieved via the TGFbeta1 signaling pathway.

10. fibrosis induced by Ang II (Montrer AGT Anticorps) may be alleviated by AKAP12 (Montrer AKAP12 Anticorps) expression through inactivation of the TGF-beta1 pathway.

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...

2. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (Montrer LDB2 Anticorps).

3. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (Montrer SMAD5 Anticorps) mediated pathway.

4. PCSK7 (Montrer PCSK7 Anticorps) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

5. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

6. TGFbeta1 plays a role in zebrafish keratocyte migration.

7. data presented show that Zili (Montrer PIWIL2 Anticorps) suppresses TGF-beta signaling by physically associating with Smad4 (Montrer SMAD4 Anticorps) and preventing the formation of Smad2 (Montrer SMAD2 Anticorps)/3/4 and Smad1 (Montrer SMAD1 Anticorps)/5/9/4 complexes

8. TGF-beta1 acts at multiple sites, including LH receptor (Montrer LHCGR Anticorps), 20beta-HSD (Montrer HAL Anticorps) and membrane progestin receptor-beta (Montrer PAQR8 Anticorps), to inhibit zebrafish oocyte maturation

9. These data suggest Pez (Montrer PTPN14 Anticorps) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

10. Data show that Rock2 (Montrer ROCK2 Anticorps) acts as a negative regulator of the TGFbeta signaling pathway.