Aperçu des produits pour anti-TGFB1 (TGFB1) Anticorps

Human Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. High TGFB1 expression is associated with fibrosis in chronic pancreatitis and pancreatic cancer.

2. This is the first evidence of downregulation of TGFbeta1-mediated activation of a Smad1 (Montrer GARS Anticorps)/5/8 signalling pathway by CCN3 (Montrer NOV Anticorps) in human podocytes and in any cell type.

3. TGFbeta1 2.5ng/ml induced the alternative splicing of extra domain A fibronectin (Montrer FN1 Anticorps) shown by conventional RT-PCR.

4. effects of both oxidative stress and LTBP2 knockdown on the extracellular matrix and apoptosis may be mediated by TGFbeta and BMP signaling pathway activation

5. We found that ITZ treatment was efficient in suppressing EMT (Montrer ITK Anticorps) and that the effect of ITZ was partially mediated by impaired TGF-b/SMAD2 (Montrer SMAD2 Anticorps)/3 signaling. The role of TGF-b/SMAD2 (Montrer SMAD2 Anticorps)/3 signaling in mediating the effect of ITZ was confirmed based on the results that recombinant TGF-b induced, but the TGF-b neutralizing antibody inhibited EMT (Montrer ITK Anticorps) as well as the invasion and migration of pancreatic cancer cells

6. our findings demonstrated that tumor cells may promote AEC II transdifferentiation. Furthermore, the transdifferentiation of AEC IIs may, in turn, induce the reactivation of 3D-established DTCs by promoting TGF-beta1/SNAI2 signaling

7. T869C polymorphism of the TGF-beta1 gene has an impact on bone mineral density and enhancement of the susceptibility to osteopenia/osteoporosis in Egyptian women.

8. GRP78 (Montrer HSPA5 Anticorps) binds to and acts in concert with a glycosylphosphatidylinositol-anchored protein, CD109 (Montrer CD109 Anticorps), in blocking TGF-beta signaling by promoting the routing of the TGF-beta receptor to the caveolae, thereby disrupting its binding to and activation of Smad2 (Montrer SMAD2 Anticorps).

9. Studies suggest that the regulation of transforming growth factor [TGF-beta] signaling in cancer metastasis which may contribute to the development of novel cancer-targeting therapies [Review].

10. studies indicate the association between transforming growth factor beta (TGF-beta)/BMP (Montrer TGFb Anticorps) signaling pathways and neuronal tissue homeostasis and development and facilitate the research with a potential to develop new therapies for neurological ailments by modulating the pathways [Review].

Cow (Bovine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 stimulated lubricin (Montrer PRG4 Anticorps) secretion by superficial zone chondrocytes at all densities with twice-a-week TGF-beta treatment. It is noteworthy that the daily treatment of TGF-beta1 increased lubricin (Montrer PRG4 Anticorps) much higher compared with twice-a-week treatment.

2. hypoxia increased the expression of platelet-derived growth factor (PDGF (Montrer PDGFA Anticorps)) and transforming growth factor-beta1 (TGF-beta1) and decreased the expression of neprilysin (NEP (Montrer MME Anticorps)), which contributed to the hypoxia-induced Endothelial-to-mesenchymal transition of pulmonary artery endothelial cells.

3. TGF-beta1 modulates the expression of syndecan-4 (Montrer SDC4 Anticorps) in cultured vascular endothelial cells in a biphasic manner.

4. Taken together, Staphylococcus aureus induces TGF-beta1 and bFGF (Montrer FGF2 Anticorps) expression through the activation of AP-1 (Montrer JUN Anticorps) and NF-kappaB (Montrer NFKB1 Anticorps) in bovine mammary gland fibroblasts.

5. The results identify TGFB1 and ESRRA (Montrer ESRRA Anticorps) as likely transcriptional regulators of rumen epithelial development and energy metabolism, respectively, and provide targets for modulation of rumen development and function in the growing calf.

6. the combined treatment with TGF-beta1 and BMP-7 (Montrer BMP7 Anticorps) or treatment first with TGF-beta1 followed by BMP-7 (Montrer BMP7 Anticorps) was more effective than other treatment groups in both chondrogenic differentiation and SZP (Montrer PRG4 Anticorps) secretion.

7. Tenascin-X (Montrer TNXB Anticorps) promotes activation of latent TGF-beta1 and subsequent epithelial to mesenchymal transition in mammary epithelial cells.

8. a detailed computational model for TGF-beta signalling that incorporates elements of previous models together with crosstalking between Smad1 (Montrer SMAD1 Anticorps)/5/8 and Smad2 (Montrer SMAD2 Anticorps)/3 channels through a negative feedback loop dependent on Smad7 (Montrer SMAD7 Anticorps).

9. Endogenous TGF-beta1 became more bioactive following activation of the transgene protein product in chondrocytes.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Rabbit Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Data indicate that cardiac contractility modulation (CCM) therapy exerted protective effects against myocardial fibrosis potentially by inhibiting TGF-beta1/Smad3 (Montrer SMAD3 Anticorps) signaling pathway in chronic heart failure .

2. study suggested that TGF-beta1/Smad3/smad7 is a major pathway which plays an important role in the regulation of the IUA and specific inhibitor of Smad3 (SIS3) may provide a new therapeutic strategy for IUA.

3. cell therapy promoted TGF-beta1 expression in nucleus pulposus, leading to anti-inflammatory effects via the inhibition of NF-kappaB (Montrer NFKB1 Anticorps), and the amelioration of disc degradation.

4. that prenatal tracheal occlusion increases TGF-beta/Rho kinase (Montrer ROCK1 Anticorps) pathway, myofibroblast differentiation, and matrix deposition in neonatal rabbit and human congenital diaphragmatic hernia lungs

5. observation. Based on the above results, we conclude that TGF-beta1-immobilized PLGA-gelatin scaffold seeded with ASCs considerably enhances the quality of the tissue-engineered cartilage, therefore, advancing the field of cartilage tissue engineering

6. Smad7 (Montrer SMAD7 Anticorps) plays a crucial role in antagonizing epithelial-mesenchymal transition induced by TGFbeta signaling and is a Notch (Montrer NOTCH1 Anticorps) signaling target in limbal epithelial stem cells.

7. the role of IL-10 in inhibited allograft rejection may be associated with CD4+CD25+ regulatory T cells and IL-10, and may be independent of TGF-b

8. After NOTCH1 (Montrer NOTCH1 Anticorps) knockdown and TGFB1 stimulation, rabbit mesenchymal stem cells expressed higher levels of proteoglycan (Montrer Vcan Anticorps) and collagen II.

9. TGF-beta1 gene transcription significantly correlates with the surgical vaginal and dermal wound closure rate.

10. A novel peptide, P2K, regulating TGF-beta1 signaling had an anabolic effect on bovine intervertebral disc cells and rabbit degenerated discs.

Guinea Pig Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF beta is involved in the pathogenesis of tympanosclerosis.

2. There was significantly higher expression of TGF-beta1 and MMP-9 (Montrer MMP9 Anticorps) in nasal mucosa of experimental allergic rhinitis guinea pigs than in controls.

Rhesus Monkey Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 regulated pAKT (Montrer AKT1 Anticorps) and IFNgamma expressions were associated with epithelial cell survival in rhesus macaque colon explants and suggest a potential role of mucosal TGF-beta1 in regulating intestinal homeostasis and EC integrity.

2. SIV infection of rhesus macaques results in the emergence of IL-17 (Montrer IL17A Anticorps)-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 (Montrer IL18 Anticorps) expression.

3. SIV-infected macaques exhibiting progression to AIDS displayed greater expression of TGF-beta and indoleamine 2,3 dioxygenase in CD8 (Montrer CD8A Anticorps)+ T cells from mesentric lymph nodes.

Pig (Porcine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. TGF-beta1 is activated or inactivated by MMP20 or KLK4 (Montrer KLK4 Anticorps) and that the amelogenin (Montrer AMELX Anticorps) cleavage product is necessary for the in-solution mobility of TGF-beta1.

2. Activated TGF-beta signaling rescued miR (Montrer MYLIP Anticorps)-143-reduced FSHR (Montrer FSHR Anticorps) and intracellular signaling molecules, and miR (Montrer MYLIP Anticorps)-143-induced porcine granulosa cell apoptosis.

3. TGF-beta1-induced epithelial-myofibroblast plasticity is FAK (Montrer PTK2 Anticorps)- dependent, whereas TGF-beta1-induced apoptosis is favored when FAK (Montrer PTK2 Anticorps) signaling is inhibited.

4. this study shows that TGF-beta1 protects intestinal integrity and influences Smad (Montrer SMAD1 Anticorps) and MAPK (Montrer MAPK1 Anticorps) signal pathways in intestinal epithelium cells after TNF-alpha (Montrer TNF Anticorps) challenge

5. this study shows that anemonin may ameliorate LPS (Montrer IRF6 Anticorps)-induced intestinal injury and improve restoration by regulating the TGF-b1 and EGFR (Montrer EGFR Anticorps) signaling pathways

6. The results indicated that TGF-beta-1 was associated with the restoration of intestinal morphology and barrier function following weaning stress.

7. Data (including data from in vitro and in vivo experiments) suggest that day 14 elongated conceptus secretes proteins that up-regulate TGFbeta1 mRNA and TGFbeta1 expression in endometrium; TGFbeta1 may be important during pregnancy maintenance.

8. The effects of semen, spermatozoa in extender, or extender alone on the expression of TGF-beta1, IL-10 (Montrer IL10 Anticorps), and IL-6 (Montrer IL6 Anticorps) in ovarian follicles are reported.

9. Dietary (1,3/1,6)-beta-D-glucan reduced the mRNA expression of transforming growth factor (TGF) beta2 (Montrer TGFB2 Anticorps) and tended to reduce the mRNA expression of TGF-beta1 in lung tissue of neonatal piglet.

10. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK (Montrer MAPK14 Anticorps) signaling, reduces CFTR (Montrer CFTR Anticorps) expression to impair CFTR (Montrer CFTR Anticorps)-mediated anion secretion, which would likely compound the effects associated with mild CFTR (Montrer CFTR Anticorps) mutations and ultimately would compromise male fertility.

Xenopus laevis Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. These data indicate that TGF-beta signaling is crucial for the function of the transition zone, which in turn may affect the regulation of cilia length.

2. R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 (Montrer SYCP3 Anticorps) serves as a vegetally enriched, intrinsic factor (Montrer GIF Anticorps) to ensure a prepared status of Smads for their activation.

3. the present in vitro system, which permits not only the cell contraction-mediated cell sorting but also the TGF-b-directed mesodermal induction such as cartilage formation, may fairly reflect the embryogenesis in vivo.

4. Loss of XTgfbi impaired blastopore formation and dorsal tissue morphogenesis.

5. TGF-beta signaling has a role in nuclear localization of transcription factor Smad4 (Montrer SMAD4 Anticorps)

6. sortilin (Montrer SORT1 Anticorps) negatively regulates TGF-beta signaling by diverting trafficking of precursor proteins to the lysosome during transit through the biosynthetic pathway

Horse (Equine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Within the limitations of the study design, production of COMP (Montrer COMP Anticorps) during healing of skin wounds does not appear to be influenced by wound type or anatomic site, nor does it appear to be correlated with TGF-beta1 concentrations.

2. Peritoneal TGF-beta(1) concentration was higher in horses with severe gastrointestinal diseases, in horses with an altered peritoneal fluid, and in nonsurvivors.

Mouse (Murine) Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. Infection with Mycobacterium bovis results in increase in interleukin-1alpha, TGF-beta1, and MMP1 (Montrer MMP1 Anticorps) in multinucleated macrophages.

2. type I and II IFN as in vivo modifiers of LIC fate that may significantly affect the impact of putative leukemia-driving activities such as the ETV6 (Montrer ETV6 Anticorps)-RUNX1 (Montrer RUNX1 Anticorps)-mediated growth advantage in the presence of TGF-beta and TLR4 (Montrer TLR4 Anticorps)-upregulated mutagenic activity

3. Osthole,a natural coumarin, decreases the collagen/III ratio in transforming growth factor beta 1 (TGF-beta1)-transfected mouse cardiac fibroblasts via the TGF-beta/Smad (Montrer SMAD1 Anticorps) signaling pathway.

4. both ERK (Montrer EPHB2 Anticorps) and Smad2 (Montrer SMAD2 Anticorps) signal pathways are involved in the activation of macrophages induced by TGF-b1 and high-ambient glucose, while there is no crosstalk shown in the process.

5. In obese mice, periodontitis caused the downregulation of MMP2 (Montrer MMP2 Anticorps), and upregulation of TIMP1 (Montrer TIMP1 Anticorps) and TGF-beta1 at transcriptional and translational levels

6. The protective effect of the EP2 receptor on TGF-beta1 induced podocyte injury via the PI3K / Akt (Montrer AKT1 Anticorps) signaling pathway.

7. This study demonstrates that prevention of renal apoB (Montrer APOB Anticorps) accumulation is a mechanism by which TGF-beta inhibition is nephroprotective.

8. data show that increased TGFbeta in the tumour microenvironment represents a primary mechanism of immune evasion that promotes T-cell exclusion and blocks acquisition of the TH1 (Montrer HAND1 Anticorps)-effector phenotype; immunotherapies directed against TGFbeta signalling may therefore have broad applications in treating patients with advanced colorectal cancer

9. IL 6 (Montrer IL6 Anticorps) and TGF beta perform essential role in cerebral malaria pathogenesis by modulating the level of glial cell induced neuroinflammation.

10. The increased susceptibility to IMQ-induced psoriasis of GILZ (Montrer TSC22D3 Anticorps)-Tg mice was significantly associated with skin-specific over-activation of TGF-beta1-mediated signaling via SMAD2 (Montrer SMAD2 Anticorps)/3.

Zebrafish Transforming Growth Factor, beta 1 (TGFB1) interaction partners

1. transforming growth factor beta (TGFbeta) is required for hematopoietic progenitor cell specification. The requirement for TGFbeta is two fold and sequential: autocrine via Tgfbeta1a and Tgfbeta1b produced in the endothelial cells themselves, followed by a paracrine input of Tgfbeta3 from the notochord, suggesting that the former programs the hemogenic endothelium and the latter drives endothelial-to-hematopoietic tran...

2. The fine tuning of TGF-beta signaling derives from positive and negative control by Ldb2a (Montrer LDB2 Anticorps).

3. TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 (Montrer SMAD5 Anticorps) mediated pathway.

4. PCSK7 (Montrer PCSK7 Anticorps) is essential for zebrafish development and regulates the expression and proteolytic cleavage of TGFbeta1a.

5. TGFbeta signaling orchestrates the beneficial interplay between scar-based repair and cardiomyocyte-based regeneration to achieve complete heart regeneration.

6. TGFbeta1 plays a role in zebrafish keratocyte migration.

7. data presented show that Zili (Montrer PIWIL2 Anticorps) suppresses TGF-beta signaling by physically associating with Smad4 (Montrer SMAD4 Anticorps) and preventing the formation of Smad2 (Montrer SMAD2 Anticorps)/3/4 and Smad1 (Montrer SMAD1 Anticorps)/5/9/4 complexes

8. TGF-beta1 acts at multiple sites, including LH receptor (Montrer LHCGR Anticorps), 20beta-HSD (Montrer HAL Anticorps) and membrane progestin receptor-beta (Montrer PAQR8 Anticorps), to inhibit zebrafish oocyte maturation

9. These data suggest Pez (Montrer PTPN14 Anticorps) plays a crucial role in organogenesis by inducing TGFbeta and epithelial-mesenchymal transition.

10. Data show that Rock2 (Montrer ROCK2 Anticorps) acts as a negative regulator of the TGFbeta signaling pathway.