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anti-Human AMFR Anticorps:
anti-Mouse (Murine) AMFR Anticorps:
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Human Polyclonal AMFR Primary Antibody pour Func, IHC - ABIN4280243
Lucarelli, Galleggiante, Rutigliano, Sanguedolce, Cagiano, Bufo, Lastilla, Maiorano, Ribatti, Giglio, Serino, Vavallo, Bettocchi, Selvaggi, Battaglia, Ditonno: Metabolomic profile of glycolysis and the pentose phosphate pathway identifies the central role of glucose-6-phosphate dehydrogenase in clear cell-renal cell carcinoma. dans Oncotarget 2015
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Human Polyclonal AMFR Primary Antibody pour FACS, IHC (p) - ABIN388938
Huang, Xie, Raz: Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor. dans Biochemical and biophysical research communications 1995
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Human Polyclonal AMFR Primary Antibody pour IHC - ABIN965545
Shimizu, Tani, Watanabe, Nagamachi, Niinaka, Shiroishi, Ohwada, Raz, Yokota: The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. dans FEBS letters 1999
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This is the first study to show that HSPA1L (Montrer HSPA1L Anticorps) mediated HIF-1alpha (Montrer HIF1A Anticorps) stabilization. In addition, this is the first study to show that GP78 inactivation promotes cancer cell proliferation, migration and eventual tumor growth both in vivo and in vitro by increasing cellular prion protein (Montrer PRNP Anticorps).
overexpression of gp78 or SVIP suppression may eliminate the toxic gain of function associated with polymerization of ZAAT, thus providing a potential new therapeutic approach to the treatment of alpha-1 antitrypsin (Montrer SERPINA1 Anticorps) deficiency
Despite its interaction with gp78, Lnp does not seem to have a broad function in degradation of misfolded ER proteins.
Further study discovered that the gp78 CUE domain works as a proofreading machine during the growth of K48-linked polyubiquitin (Montrer UBB Anticorps) chains to ensure the linkage specificity. Together, our studies uncover a novel mechanism underlying the linkage specificity determination of longer polyubiquitin (Montrer UBB Anticorps) chains.
AMFR expression is significantly reduced in plasma from osteoporosis patients.
Catalytic inactivation of MGRN1 (Montrer MGRN1 Anticorps) results in elevated levels of GP78 and a consequential increase in the initiation of mitophagy.
Authors conclude that the Hrd1 (Montrer SYVN1 Anticorps) complex forms an essential retrotranslocation module that is evolutionarily conserved, but the mammalian ERAD system uses additional ubiquitin ligases to assist Hrd1 (Montrer SYVN1 Anticorps) during retrotranslocation.
Downregulation of AMFR induced cell cycle arrest at the G0/G1 phase, and increased apoptosis of the THP1 (Montrer GLI2 Anticorps) cells.
The authors identify USP13 (Montrer USP13 Anticorps) as a gp78-associated deubiquitinase that eliminates ubiquitin conjugates from Ubl4A (Montrer UBL4A Anticorps) to maintain the functionality of Bag6 (Montrer BAT3 Anticorps).
Data show that autocrine motility factor receptor (AMFR) and NOTCH1 (Montrer NOTCH1 Anticorps) protein are the direct target genes of microRNA miR (Montrer MLXIP Anticorps)-139-5p in colorectal cancer (CRC (Montrer CALR Anticorps)).
the role of gp78 and cidec (Montrer CIDEC Anticorps) in hepatic steatosis, were investigated.
Gp78, an E3 ubiquitin ligase (Montrer MUL1 Anticorps) acts as a gatekeeper suppressing nonalcoholic steatohepatitis (NASH (Montrer SAMSN1 Anticorps)) and liver cancer.
The ubiquitin ligase (Montrer RNF123 Anticorps) gp78, known for its role in protein quality control, is critical for unglycosylated PrP ubiquitylation and degradation.
we consistently observe involvement of gp78 in Insig-1 (Montrer INSIG1 Anticorps) degradation, we find no substantive evidence to support roles for either gp78 or TRC8 (Montrer RNF139 Anticorps) in the robust sterol-accelerated degradation of HMG-CoA reductase (Montrer HMGCR Anticorps)
Ablation of gp78 in liver improves hyperlipidemia and insulin (Montrer INS Anticorps) resistance by inhibiting SREBP to decrease lipid biosynthesis.
Palmitoylation of RING finger (Montrer PCGF1 Anticorps) cysteines therefore regulates gp78 distribution to the peripheral ER
AMFR is involved in the process of learning and memory in the central nervous system.
KAI1 has a role in promotion of cell proliferation and mammary gland hyperplasia by the gp78 ubiquitin ligase
Gp78 promotes SOD1 (Montrer SOD1 Anticorps) and ataxin-3 (Montrer ATXN3 Anticorps) degradation in endoplasmic reticulum.
cytoplasmic protein (Montrer BLZF1 Anticorps) mouse p97 (Montrer EIF4G2 Anticorps)(mp97) participates in the formation of a ternary complex containing mouse autocrine motility factor receptor (mAMFR), mp97, and peptide N-glycanase
gp78 plays a critical role in protecting against ER stress in liver
This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins.
E3 ubiquitin-protein ligase AMFR
, RING finger protein 45
, AMF receptor
, autocrine motility factor receptor
, autocrine motility factor receptor, amfr
, autocrine motility factor receptor amfr
, autocrine motility factor receptor, isoform 2-like