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Aperçu des produits pour anti-Der1-Like Domain Family, Member 1 (DERL1) Anticorps

Full name:: anti-Der1-Like Domain Family, Member 1 Anticorps (DERL1)

Chez www.anticorps-enligne.fr sont 59 Der1-Like Domain Family, Member 1 (DERL1) Anticorps de 11 de différents fournisseurs disponibles. De plus, nous expédions Der1-Like Domain Family, Member 1 Protéines (4) et beaucoup plus de produits pour cette protéine. Un total de 64 Der1-Like Domain Family, Member 1 produits sont actuellement listés.

Synonymes:: 1110021N07Rik, AI195141, AW551338, CG10908, DDBDRAFT_0188135, DDBDRAFT_0266772, DDB_0188135, DDB_0266772, DER-1, DER1, DERLIN-1, Dmel\\CG10908, F17A13.150, F17A13_150, MGC84200, RGD1311835, wu:fb09d07, wu:fb94d05, wu:fj92g12, zgc:55637

afficher tous les anticorps	Gène	GeneID	UniProt
	DERL1	67819	Q99J56
	DERL1	79139	Q9BUN8
	DERL1	362912
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Pathways pertinentes pour anti-Der1-Like Domain Family, Member 1 Anticorps

ER-Nucleus Signaling

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Polyclonal DERL1 Primary Antibody pour IHC (fro), WB - ABIN540747 : Schekman: Cell biology: a channel for protein waste. dans Nature 2004 (PubMed)
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Chinese Hamster Polyclonal DERL1 Primary Antibody pour ICC, IF - ABIN151899 : Huttunen, Guénette, Peach, Greco, Xia, Kim, Barren, Tanzi, Kovacs: HtrA2 regulates beta-amyloid precursor protein (APP) metabolism through endoplasmic reticulum-associated degradation. dans The Journal of biological chemistry 2007 (PubMed)
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Plus d’anticorps contre Der1-Like Domain Family, Member 1 partenaires d’interaction

Mouse (Murine) Der1-Like Domain Family, Member 1 (DERL1) interaction partners

The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.
Cav-1 may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 and may facilitate Derlin-1- and p97 complex-mediated COX-2 ubiquitination, retrotranslocation, and degradation.
Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice
Derlin-1 regulates the turnover of superoxide dismutase 1 by promoting the proteasomal and autophagosomal degradation of SOD1 protein, but not by decreasing mutant SOD1 mRNA levels.
Perturbation of binding between SOD1(mut) and Derlin-1 by Derlin-1-derived oligopeptide suppressed SOD1(mut)-induced ER stress, ASK1 activation, and motor neuron death.

Human Der1-Like Domain Family, Member 1 (DERL1) interaction partners

association of the degradation factor HRD1 with the translocon and the rerouting factor Derlin-1 may be necessary for the smooth and effective clearance of ERpQC substrates
Overexpression of Derlin-1 is Associated with Non-small Cell Lung Cancer.
These findings for the first time revealed that miR-598, as a tumor suppressor, negatively regulate DERL1 and Epithelial-Mesenchymal Transition to suppress the invasion and migration in Non-Small Cell Lung Cancer (NSCLC), thereby putatively serving as a novel therapeutic target for NSCLC clinical treatment.
ChIP assays were used to ascertain the correlations between HNF1beta and Derlin-1 in the miR-217/HNF1beta/Derlin-1 pathway in glioma cells
The derlin-1 pathway therefore may represent a significant early checkpoint in the recognition and degradation of ENaC in mammalian cells.
Derlin-1 is overexpressed in bladder cancer and promotes malignant phenotype through ERK/MMP-2/9 and PI3K/AKT signaling pathway.
Derlin-1 was overexpressed in bladder cancer and was associated with the malignancy of bladder cancer.
insights into the interactions between other SHP-containing proteins and p97N
data suggest that miR-181d is a tumor suppressor in ESCC inversely regulating its downstream target gene of DERL1.
Results showed that Derlin-1 is overexpressed in colon cancer and promotes proliferation of colon cancer cells.
TMEM129 contains an unusual cysteine-only RING with intrinsic E3 ligase activity and is recruited to US11 via Derlin-1.
Cav-1 may be a cofactor in the interaction of Derlin-1 and N-glycosylated COX-2 and may facilitate Derlin-1- and p97 complex-mediated COX-2 ubiquitination, retrotranslocation, and degradation.
Derlin-1 is overexpressed in non-small cell lung cancer and promotes invasion by EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9.
Upregulation of derlin-1 may be associated with endoplasmic reticulum stress in neuronal cells in Alzheimer's disease.
These results indicate that ApoB after lipidation is dislocated from the ER lumen to the LD surface for proteasomal degradation and that Derlin-1 and UBXD8 are engaged in the predislocation and postdislocation steps, respectively.
Derlin-1 expression levels may affect glucose-stimulated insulin secretion by altering surface expression of K(ATP) channels.
Derlin-1 is a negative regulator for both glycosylated and non-glycosylated BCRP expression and provide a novel posttranslational regulatory mechanism of BCRP by Derlin-1.
Derlin-1 is an important factor for the extraction of certain aberrantly folded proteins from the mammalian ER
Derlin-1 interacts with US11, a virally encoded ER protein that specifically targets MHC class I heavy chains for export from the ER, as well as with VIMP, a novel membrane protein that recruits the p97 ATPase and its cofactor
Derlin-1 interacts with the N-terminal domain of PNGase via its cytosolic C-terminus. PNGase distributed in two populations; ER-associated and free in the cytosol, which suggests the deglycosylation process can proceed at either site

Cow (Bovine) Der1-Like Domain Family, Member 1 (DERL1) interaction partners

A role for DERL1 in tissue remodeling events and maintenance of function in reproductive tissues.

Der1-Like Domain Family, Member 1 (DERL1) profil antigène

Antigen Summary

The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Alternative names and synonyms associated with Der1-Like Domain Family, Member 1 (DERL1)

Derlin-1 (Der-1) anticorps
derlin-1 (EDI_023440) anticorps
derlin-1.1 (PTRG_01331) anticorps
hypothetical protein (derl1) anticorps
Der1-like domain family, member 1 (DERL1) anticorps
derlin 1 (derl1) anticorps
derlin 1 L homeolog (derl1.L) anticorps
derlin 1 (DERL1) anticorps
Der1-like domain family, member 1 (Derl1) anticorps
derlin 1 (Derl1) anticorps
DERLIN-1 (DER1) anticorps

1110021N07Rik anticorps
AI195141 anticorps
AW551338 anticorps
CG10908 anticorps
DDBDRAFT_0188135 anticorps
DDBDRAFT_0266772 anticorps
DDB_0188135 anticorps
DDB_0266772 anticorps
DER-1 anticorps
DER1 anticorps
DERLIN-1 anticorps
Dmel\\CG10908 anticorps
F17A13.150 anticorps
F17A13_150 anticorps
MGC84200 anticorps
RGD1311835 anticorps
wu:fb09d07 anticorps
wu:fb94d05 anticorps
wu:fj92g12 anticorps
zgc:55637 anticorps

Protein level used designations for DERL1

CG10908-PA , CG10908-PB , Der-1-PA , Der-1-PB , Dm Derlin-1 , derlin-1 , derlin-1.1 , Der1-like domain family, member 1 , Der1-like protein 1 , degradation in endoplasmic reticulum protein 1 , der1-like protein 1 , DERtrin-1

GENE ID	SPECIES
33369	Drosophila melanogaster
5882626	Entamoeba dispar SAW760
6338400	Pyrenophora tritici-repentis Pt-1C-BFP
8626833	Dictyostelium discoideum AX4
100158198	Sus scrofa
100528714	Ictalurus punctatus
444811	Xenopus laevis
464364	Pan troglodytes
549477	Xenopus (Silurana) tropicalis
703803	Macaca mulatta
100355027	Oryctolagus cuniculus
406753	Danio rerio
67819	Mus musculus
420350	Gallus gallus
79139	Homo sapiens
475086	Canis lupus familiaris
404121	Bos taurus
362912	Rattus norvegicus
100172781	Pongo abelii
829054	Arabidopsis thaliana

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