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anti-Human NRF2 Anticorps:
anti-Mouse (Murine) NRF2 Anticorps:
anti-Rat (Rattus) NRF2 Anticorps:
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Human Polyclonal NRF2 Primary Antibody pour IF (p), IHC (p) - ABIN737271
Lee, Hsu, Chang, Kuo, Hsu, Pan: Ankaflavin: a natural novel PPAR? agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. dans Free radical biology & medicine 2012
Show all 22 Pubmed References
Human Polyclonal NRF2 Primary Antibody pour IHC (fro), IF (p) - ABIN676673
Lee, Hsu, Hsu, Pan: Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid. dans Free radical biology & medicine 2013
Show all 19 Pubmed References
Human Polyclonal NRF2 Primary Antibody pour ChIP, ICC - ABIN442777
Sullivan, Martinez-Garcia, Nguyen, Mullen, Dufour, Sudarshan, Licht, Deberardinis, Chandel: The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling. dans Molecular cell 2013
Show all 11 Pubmed References
Human Polyclonal NRF2 Primary Antibody pour IHC, WB - ABIN6711856
Xu, Gao, Niu, Li, Wang, Gao, Ding, Yao, Chai, Li: Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats. dans Acta pharmacologica Sinica 2014
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Human Polyclonal NRF2 Primary Antibody pour IF, WB - ABIN6714637
Park, Jeon, Kim, Roh, Shin, Sung, Han, Kang: Aged red garlic extract reduces lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages and acute pulmonary inflammation through haeme oxygenase-1 induction. dans Acta physiologica (Oxford, England) 2012
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Human Polyclonal NRF2 Primary Antibody pour IHC, IHC (p) - ABIN4340688
Suchocki, Misiewicz-Krzemińska, Skupińska, Niedźwiecka, Lubelska, Fijałek, Kasprzycka-Guttman: Selenitetriglicerydes affect CYP1A1 and QR activity by involvement of reactive oxygen species and Nrf2 transcription factor. dans Pharmacological reports : PR 2010
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Mouse (Murine) Polyclonal NRF2 Primary Antibody pour IHC, WB - ABIN3021832
Xu, Zhang, Lu, Deng, Zhao, Zhao, Zhao: Prevention of Hippocampal Neuronal Damage and Cognitive Function Deficits in Vascular Dementia by Dextromethorphan. dans Molecular neurobiology 2016
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Human Polyclonal NRF2 Primary Antibody pour IHC, WB - ABIN6672724
Meng, Song, Wang, Li, Liu, Cui: Propofol induces proliferation partially via downregulation of p53 protein and promotes migration via activation of the Nrf2 pathway in human breast cancer cell line MDA-MB-231. dans Oncology reports 2017
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Human Monoclonal NRF2 Primary Antibody pour IF, ELISA - ABIN518315
Lindl, Jordan-Sciutto: Examining the endogenous antioxidant response through immunofluorescent analysis of Nrf2 in tissue. dans Methods in molecular biology (Clifton, N.J.) 2008
Rat (Rattus) Polyclonal NRF2 Primary Antibody pour ICC, IHC - ABIN1869445
Baluchnejadmojarad, Zeinali, Roghani: Scutellarin alleviates lipopolysaccharide-induced cognitive deficits in the rat: Insights into underlying mechanisms. dans International immunopharmacology 2017
Nrf2a-deficient zebrafish showed higher susceptibility to oxidative stress, and higher vulnerability to acetaminophen- or doxorubicin-induced toxicity.
by performing protein profiling on isolated astrocytes we showed that an increase in astrocytic DJ-1 expression up-regulated a large group of proteins associated with redox regulation, inflammation and mitochondrial respiration. The majority of these proteins have also been shown to be regulated by Nrf2.
Nrf2 was activated in response to the ER stress via the PERK pathway.
Knockdown of Nrf2 paralogs perturbed glutathione redox state in zebrafish embryo. Nrf2 alone is not essential for the response and recovery of glutathione to oxidative insults.
nrf2a modulates the embryonic response to perfluorooctanesulfonic acid (PFOS), and that PPAR signaling may play a role in the embryonic adaptive response to PFOS.
These results suggest that alpha,beta-unsaturated carbonyl entity and catechol moiety of 6S derivatives may react with the cysteine residues of Keap1, disrupting the Keap1-Nrf2 complex, thereby liberating and activating Nrf2. Our findings of natural product-derived Nrf2 activators lead to design options of potent Nrf2 activators for further optimization.
These data suggest that EC from the Tripterygium wilfordii stem extract could diminish tau-GFP-induced neuronal death through the activation of Nrf2.
we concluded that Nrf2 plays a fundamental and conserved role in protection against acute sodium arsenite toxicity
Coptisine exerted its antioxidant activity against AAPH-induced toxicity involving in activating Akt and JNK/Nrf2/NQO1 pathway.
Bach1 regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
The expression of nrf genes varies temporally throughout development and nrf genes are induced following a pro-oxidant exposure and are potentially cross-regulated by gene family members Nrf2a and Nrf2b.
oxidative stress is an important mechanism of Cd-mediated injury in the zebrafish olfactory system; the Nrf2 pathway plays a protective role against cellular oxidative damage and is important in maintaining zebrafish olfactory function.
results revealed that nrf2 mutant zebrafish are viable and fertile but show an increased susceptibility to oxidative stress and electrophiles
compared the tissue-specific expression of several Nrf2 target genes in zebrafish larvae; Tissue-restricted induction was observed in the nose, gill, and/or liver for seven genes in response to Nrf2-activating compounds
Nrf2 is protective against PFOS-induced oxidative stress in zebrafish larvae.
mutation of either residual cysteine residue in Keap1a and Keap1b disrupted the ability of Keap1 to repress Nrf2, indicating that the presence of either Cys-273 or Cys-288 is sufficient for fish Keap1 molecules to fully function
study reports that the Keap1-Nrf2 system comprises discrete sensor sites, including the Keap1 cysteines Cys-151 and Cys-273, for a variety of Nrf2-activating compounds
findings demonstrate that antioxidant responses are a component of polycyclic aromatic hydrocarbon (PAH)synergistic developmental toxicity and that NRF2 is protective against prooxidant and PAH challenges during development
this study highlighted the involvement of miR-153, miR-28 and miR-708 in regulatory network of Nrf2 mediated antioxidant system in bovine granulosa cells function.
These findings suggest that bronchiolar epithelial cells and macrophages up-regulate Nrf2 expression early in the course of infection, which results in increased expression of HO-1 within these cells.
the survival and developmental competence of embryos cultured under oxidative stress are associated with activity of the NRF2-mediated oxidative stress response pathway during bovine pre-implantation embryo development.
expression of target genes in liver in transition period and stages of lactation
investigation of molecular mechanisms of microvascular complications in diabetes/hyperglycemia: Nrf2 is involved in regulation of HO-1 gene expression in aortic endothelial cells by advanced glycation end products
The results of the current study indicate that dioscin may protect against coronary heart disease by regulating oxidative stress and inflammation via Sirt1/Nrf2 and p38 MAPK pathways.
Lack of Nrf2 enhances susceptibility to mycotoxin-induced kidney disease.
The effects of ochratoxin A on the nuclear translocation and transactivation of the transcription factor Nrf2 as well as mRNA levels of Nrf2 target genes are reported.
Treatment with genistein significantly improved the altered cardiac function markers and oxidative stress markers. Genistein enhanced the Nrf2 and HO-1 expression, which showed protection against oxidative insult induced by doxorubicin.
These data demonstrated that external stimuli (eg, oxidative stress) may trigger autocrine HMGB1 translocation and release by melanocytes, suppressing the expression of Nrf2 and downstream antioxidant genes to induce melanocyte apoptosis, and thereby participate in the pathological process of vitiligo.
Nrf2 prevents inflammation caused by layer house PM2.5 stimulation, however, autophagy exerts a promotive role in TLR4 - NFkappaB p65 mediating inflammation in A549cell.
The HBXIP-mediated reduction in NRF2-KEAP1 complexes promotes NRF2 accumulation.
basal and inducible regulation of LAMP2A, and consequently Chaperone-mediated autophagy activity, by NFE2L2, is reported.
The Nrf2 is involved in other cellular processes, such as autophagy, intermediary metabolism, stem cell quiescence, and unfolded protein response.
The NRF2 plays during inflammation, the relationship between NRF2 and other transcription factors and mediators of inflammation still remains ambiguous.
The NRF2-KEAP1 signaling pathway is altered in cancer, how NRF2 is regulated by changes in cellular metabolism, and how NRF2 reprograms cellular metabolism to support proliferation.
The NRF2 activation and alterations to iron signaling in cancers may hinder efforts to induce the iron-dependent cell death process known as ferroptosis.
Nrf2-mediated metabolic reprogramming of tolerogenic dendritic cells is protective against aplastic anemia.
TRIM16 activates ubiquitin pathway genes and p62 via NRF2, leading to ubiquitination of misfolded proteins and formation of protein aggregates.
Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer.
study identifies Nrf2 plays a central role in skewing Th1 and Th2 dominance in the progression of diabetes.
Nrf2-IR was detected in the cytoplasm and nuclei of hair cells and supporting cells thorough the human cochlea and the vestibular sensory epithelia. Nrf2-IR decreases significantly the cochlea of older individuals, but no in disease specimens. Nrf2 expression may be a good candidate to prevent and or protect from hearing loss due to noise, exposure to ototoxic drugs and normal and pathological aging.
The ability of Nfr2 activation in preventing this effect.
Our results provide the first evidence that primary human mast cells (MCs) exhibit substantial Nrf2 activity, which can effectively suppress MC activation and degranulation induced by Substance P.
In vitro experiments in human bronchial epithelial cells demonstrated that Nrf2 activated by bixin contributes to tissue repair by alleviating oxidative stress, increasing proliferation and migration, decreasing apoptosis, which may be partially through modulating the expression of MMP9, TGFbeta1, and FN.
The Nrf2 signaling pathway in normal cells maintains the cellular environment, and genomic stability and acts a tumor suppressing gene.Nrf2 promotes tumor growth and enhances drug resistance in ovarian cancer.[review]
heat shock-generated ROS were involved in induction of cellular defense molecules Prxs, GSH and G6PD through Nrf2 activation.
These results highlight the critical role of Nrf2/antioxidant response elements in the maintenance of Down syndrome cell homeostasis.
NRF2 may be implicated in memory and activity functions and its deletion exacerbates deficits associated with aging.
DUSP14 up-regulation inhibits inflammation and oxidative stress in brain of cerebral ischemia/reperfusion mice. DUSP14 evokes Nrf-2-meditated anti-oxidative stress and inflammatory response.
Mice deficient in IL-17D or the transcription factor Nuclear factor (erythroid-derived 2)-like 2 (Nrf2), an inducer of IL-17D, featured an early decreased number of innate immune cells at the point of viral entry and were more susceptible to mouse cytomegalovirus infection.
data point to transcription factor NRF2 as a major mediator of oxidized palmitoyl-arachidonoyl-phosphatidylcholine -induced upregulation of SCF. This mechanism may represent one of the facets of pleiotropic action of NRF2 in vascular wall.
results confirmed a protective role for Nrf2 in late-stage carcinogenesis and, unexpectedly, suggest that activation of Nrf2 in immune cells may be advantageous for preventing or treating lung cancer
DC32 significantly suppressed rheumatoid arthritis (RA) via the Nrf2-p62-Keap1 feedback loop.
Oxidative Stress Induces an Interactive Decline in Wnt and Nrf2 Signaling in Degenerating Retinal Pigment Epithelium
The results from the in vivo study showed that bixin treatment attenuated the accumulation of inflammatory cells, decreased the levels of tissue apoptosis, and increase the ability of cell proliferation. Besides that, bixin also could regulate the expression of MMP9, TGFbeta1, and its downstream Fibronectin (FN), along with activation of Nrf2 signals
In mice, activation of the Nrf2 and SIRT1 signaling pathways ameliorated oxidative stress and mitochondrial dysfunction. Pharmacological targeting of Nrf2 signaling molecules may reduce the pathologic changes of aging in the kidney.
c-Src-mediated regulation of Nrf2 transcriptional activity, via PKCdelta activation.
Our results revealed a novel link between Mkp-1 and Nrf2 signaling pathways in protecting against colonic inflammation
NRF2 is required for both self-defense and sodium butyrate's protection against diabetes-induced aortic endothelial dysfunction. Other findings suggest that P300 mediates the transcriptional activation of Nrf2 by sodium butyrate
Collectively, Nrf2 dysfunction exacerbates the deleterious effects of obesity, compromising cerebromicrovascular and brain health by impairing neurovascular coupling mechanisms, BBB integrity and synaptic function and promoting neuroinflammation.
Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation.
camel whey protein supplemented heat stress (HS) mice exhibited complete restoration of Bcl2, P53, Nrf2, and PPAR-gamma expressions; testicular Leydig cell distribution; significant higher levels of testosterone levels; and hence higher percentages of progressively motile sperm and lower percentages of immotile sperm as compared to HS mice.
Silencing Keap1 was able to reverse the inhibitory effect of Axitinib and enhance the protein expressions of Nrf2, NAD(P)H dehydrogenase [quinone] 1 and heme oxygenase 1.
Study results suggest that Nrf2 is a critical regulator of innate, inflammatory, and disease-associated responses in the airways of mice infected with viruses that are members of the Pneumoviridae family. Nrf2-dependent genes, including those controlling the cellular antioxidant and H2S-generating enzymes and cytokines can affect several aspects of the antiviral response.
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters\; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been found for this gene.
, nuclear factor (erythroid-derived 2)-like 2
, nuclear factor erythroid 2-related factor 2
, NF-E2-related factor 2
, NFE2-related factor 2
, nuclear factor, erythroid derived 2, like 2
, nuclear factor erythroid-derived 2-like 2
, nuclear factor erythroid 2-like 2