anti-Humain AKT1 Substrate 1 (Proline-Rich) anticorps pour Immunocytochemistry

Recommended AKT1 Substrate 1 (Proline-Rich) Antibody (fourni par: Connectez-vous pour afficher )

Antigène
AKT1 Substrate 1 (Proline-Rich) (AKT1S1) Anticorps
  • MGC81452
  • lobe
  • pras40
  • fb34a04
  • wu:fb34a04
  • Lobe
  • PRAS40
  • 1110012J22Rik
  • AI227026
  • Lobel
  • AKT1 substrate 1 (proline rich) S homeolog
  • AKT1 substrate 1
  • AKT1 substrate 1 (proline rich)
  • AKT1 substrate 1 (proline-rich)
  • akt1s1.S
  • AKT1S1
  • akt1s1
  • Akt1s1
Reactivité
Humain
109
51
44
13
6
6
5
5
3
2
2
1
1
Hôte
Lapin
90
22
Clonalité
Polyclonal
Conjugué
Inconjugué
5
5
4
3
3
3
1
Application
ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
105
54
47
14
9
6
2
2
Fournisseur
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N° du produit (Fournisseur)
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N° du produit ABIN6259870
$ 390.77
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
1 ABIN4347194 ELISA ICC IF IHC WB Rabbit C-Term Connectez-vous pour afficher Polyclonal 0
1 ABIN5078999 ICC IF Rabbit IgG Connectez-vous pour afficher Polyclonal 0

General

Antigène AKT1 Substrate 1 (Proline-Rich) (AKT1S1) Anticorps
Reactivité Humain
(109), (51), (44), (13), (6), (6), (5), (5), (3), (2), (2), (1), (1)
Hôte Lapin
(90), (22)
Clonalité
Polyclonal
Conjugué Inconjugué
(5), (5), (4), (3), (3), (3), (1)
Application ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
(105), (54), (47), (14), (9), (6), (2), (2)
Fournisseur Connectez-vous pour afficher

Détail du produit

Détail du antigène Information d'application Stockage Images
Specificité AKT1S1 Antibody detects endogenous levels of total AKT1S1
 Réactivité croisée Humain
Purification The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
Immunogène A synthesized peptide derived from human AKT1S1
Isotype IgG

Détail du antigène

Détail du produit Information d'application Stockage Images Haut de la page
Antigène
Autre désignation AKT1S1 (AKT1S1 Antibody Extrait)
Sujet

Description: Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.

Gene: AKT1S1

Poids moléculaire 27 kDa
ID gène 84335
UniProt Q96B36
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Autophagy

Information d'application

Détail du produit Détail du antigène Stockage Images Haut de la page
Indications d'application WB 1:1000-3000, IF/ICC 1:100-1:500
Restrictions For Research Use only

Stockage

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Format Liquid
Concentration 1 mg/mL
Buffer Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20 °C.Stable for 12 months from date of receipt
Date de péremption 12 months