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anti-Human FCER1G Anticorps:
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The structure of the adaptor protein fcer1g has been identified in the zebrafish genome.
FCER1G was identified and validated in association with ccRCC progression and prognosis, which might improve the prognosis by influencing immune-related pathways
mass spectrometry of WT human FcRgamma from receptor-stimulated cells shows consistent preferential phosphorylation of the serine residue at position 51.
FcgammaR-mediated Syk activation leads to NLRP3 inflammasome-dependent IL-1beta production in macrophages and suggests that an Nlrp3- and IL-1R-dependent process contributes to the IgA response important for protection against Francisella tularensis LVS.
Data indicate that the decreasing trend in the expression level of TCRzeta chain, ZAP-70 kinase and epsilon Fc Receptors FcvarepsilonRIgamma was significantly associated with disease progression.
Studies indicate that in response to stimulation with antigen, PHB1 translocated to plasma membrane lipid rafts to form a ternary complex with the high-affinity IgE receptor FcepsilonRIgamma and the nonreceptor tyrosine kinase Syk.
High expression of FCER1G is associated with chronic myeloid leukemia.
There was loss of the negative correlation in the expression levels of CD3eta and FcepsilonRIgamma genes in CLL patients.
CD2-associated adaptor protein (CD2AP) positively regulates blood dendritic cell antigen 2 (BDCA2)/FcepsilonR1gamma signaling by forming a complex with SH2 domain-containing inositol 5'-phosphatase (SHIP)1 to inhibit the E3 ubiquitin ligase Cbl.
Altered expression of the TCR signaling related genes CD3 and FcepsilonRIgamma in patients with aplastic anemia.
Demethylation of specific regulatory elements within the FCER1G locus contributes to FcepsilonRI overexpression on monocytes from patients with atopic dermatitis.
No associations with total and specific IgE levels as well as allergic sensitization were seen for FCER1B and FCER1G
Data suggest a contribution of Fc epsilonRI alpha and gamma chains either to immunosurveillance or pathophysiology of the intestinal epithelium.
Conservation of FcepsilonRI gamma chain coding region in normals and in SLE patients.
FCGR3B quantification confirms the idea of the HNA-1c antigen to be inherited not only linked to HNA-1a, but also to be passed down on its own.
Overexpression of the Fc epsilon RI gamma chain in normal T cells associates with TCR/CD3 complex, contributes to altered T cell signaling, and down-regulates the endogenous TCR zeta-chain expression in human T cells.
evidence that FcepsilonRI-gamma (gamma) associates with 2DL4 to promote surface expression and provide signal transducing function.
Data suggest that by associating with Fc epsilon RI gamma, BDCA2 activates a novel BCR-like signaling pathway to regulate the immune functions of plasmacytoid dendritic cells.
The activating functions of KIR2DL4 killer receptor in natural killer (NK) cells are compartmentalized into distinct structural modules through transmembrane association with the Fc epsilon RI-gamma (FCERIG) receptor.
Elf-1 in combination with Sp1 and GABP reduced FcRgamma promoter activity.
reduced expression in histamin non-releaser basophils
this study shows the CD23-induced signaling pathways and their roles in antifungal immunity, specifically for Candida albicans and Aspergillus fumigatus
FC epsilon RI receptor role in the mast cell activation and anaphylaxis.Sirt1 negatively regulates Fc epsilon RI-stimulated mast cell activation and anaphylaxis through two mutually regulated pathways involving AMP-activated protein kinase (AMPK) and protein tyrosine phosphatase 1B.
Data (including data from studies conducted with cells from knockout mice) suggest that Cd300e on the surface of monocytes or mast cells recognizes the ligand sphingomyelin and thereby regulates non-classical and intermediate immunologic functions through FcRgamma and DAP12. (Cd300e = CD300 antigen like family member E; FcRgamma = Fc receptor subunit gamma; DAP12 = DNAX-activation protein-12)
CD23 deficiency impacts the early cellular event of B-cell receptor (BCR) activation.
Dock10 negatively regulates membrane CD23 expression; negative regulation of CD23 expression by Dock10 could play a role in B cell maturation and function
data are significant in uncovering a latent, but potent, negative-regulatory role for Myd88 and Fcer1g in the late stages of B cell responses; such roles could limit acute responses; however, they could be particularly significant in chronic responses, such as autoimmunity and chronic infection
this study reveal an autonomous membrane IgE signaling mechanism that normally prevents IgE(+) memory B cells and long-lived plasma cells formation, providing insights into the molecular pathogenesis of allergic diseases.
Galectin-3 regulates IgE receptor signaling in mast cells.
these results identify a previously unproven mechanism in which epithelial CD23 plays a central role in the development of allergic inflammation
In mast cells, ORMDL3 functions predominantly as a negative regulator of FcepsilonRI-mediated signaling events leading to the expression of proinflammatory mediators and chemotaxis.
Data show that although phospholipase D PLD1 deficiency impaired Fc epsilon receptor FcepsilonRI-mediated signaling and mast cell function, phospholipase D PLD2 deficiency actually enhanced these pathways.
Glomerulonephritis in FcRgamma-/- chimeras was no different from wild type.
Acidic pH augments Fc-epsilon-RI-mediated production of IL-6 and IL-13 in mast cells.
Data indicate that absence of complement C3, complement C5 and Fc receptor subunit gamma (FcRgamma) does not impact autoantibody production in K/BxN mice.
Canonical tyrosine residues mutation in FceRIg ITAM (Y65 and Y76) reveals that these two tyrosine residues in gamma subunit are required for its interaction with type II PtdIns 4-kinases.
Data indicate that phosphorylation of Tyr114 and Tyr259 of prohibitin (PHB) is critical for the association of PHB with FcRI and Syk.
critical for TGFbeta2-treated macrophage-induced tolerance
plays role in beta2 adrenergic receptor-induced increase in IgE on B cells
the CD23 surface level and serum IgE level are uncoupled and that neither is directly regulated by the mutations within the CD23 coding region.
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors.
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
, high affinity IgE receptor gamma subunit
, Fc fragment of IgE, high affinity I, receptor for, gamma polypeptide
, Fc receptor, IgE, high affinity I, gamma polypeptide
, high affinity IgE Fc receptor gamma-subunit
, Fc receptor gamma-chain
, fc-epsilon RI-gamma
, fceRI gamma
, high affinity immunoglobulin epsilon receptor subunit gamma
, immunoglobulin E receptor, high affinity, gamma chain
, gamma polypeptide
, igE Fc receptor subunit gamma
, Fc epsilon receptor gamma chain
, high-affinity IgE receptor gamma-chain