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Human Polyclonal PDGFRB Primary Antibody pour CyTOF, FACS - ABIN4900243
Campbell, Allen, Silversides, Trimble et al.: Glucose-induced phosphatidylinositol 3-kinase and mitogen-activated protein kinase-dependent upregulation of the platelet-derived growth factor-beta receptor potentiates vascular smooth muscle cell ... dans Diabetes 2003
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Human Monoclonal PDGFRB Primary Antibody pour FACS, IHC - ABIN4900877
Nagineni, Kutty, Detrick, Hooks: Expression of PDGF and their receptors in human retinal pigment epithelial cells and fibroblasts: regulation by TGF-beta. dans Journal of cellular physiology 2005
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Human Monoclonal PDGFRB Primary Antibody pour FACS - ABIN4898828
Frassanito, Rao, Moschetta, Ria, Di Marzo, De Luisi, Racanelli, Catacchio, Berardi, Basile, Menu, Ruggieri, Nico, Ribatti, Fumarulo, Dammacco, Vanderkerken, Vacca: Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies. dans Leukemia 2014
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Human Monoclonal PDGFRB Primary Antibody pour ELISA, WB - ABIN966814
Hansen, Rönnstrand, Rorsman, Hellman, Heldin: Association of coatomer proteins with the beta-receptor for platelet-derived growth factor. dans Biochemical and biophysical research communications 1997
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Human Monoclonal PDGFRB Primary Antibody pour ELISA, WB - ABIN969346
Wilczynski, Chen, Chen, Howell, Shively, Alberts: Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers. dans Human pathology 2005
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Human Monoclonal PDGFRB Primary Antibody pour FACS - ABIN2688973
Ebert, Kasper, Hernberg, Friess, Büchler, Roessner, Korc, Malfertheiner: Overexpression of platelet-derived growth factor (PDGF) B chain and type beta PDGF receptor in human chronic pancreatitis. dans Digestive diseases and sciences 1998
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Human Monoclonal PDGFRB Primary Antibody pour ICS - ABIN1177131
Claesson-Welsh: Platelet-derived growth factor receptor signals. dans The Journal of biological chemistry 1995
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Human Monoclonal PDGFRB Primary Antibody pour ICS - ABIN1177133
Liu, Oh, Horner, Rogers, Schnitzer: Organized endothelial cell surface signal transduction in caveolae distinct from glycosylphosphatidylinositol-anchored protein microdomains. dans The Journal of biological chemistry 1997
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Human Monoclonal PDGFRB Primary Antibody pour FACS - ABIN4898826
Guijarro-Muñoz, Cuesta, Alvarez-Cienfuegos, Geng, Alvarez-Vallina, Sanz: The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. dans Experimental cell research 2012
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Human Polyclonal PDGFRB Primary Antibody pour IF, IHC - ABIN1532980
Yu, Zeidel, Hill: Cellular expression profile for interstitial cells of cajal in bladder - a cell often misidentified as myocyte or myofibroblast. dans PLoS ONE 2012
PDGFRbeta was activated around the injury site after experimental traumatic brain injury (TBI), and primarily expressed in astrocytes, microglia, OPC and leukocytes in the boundary of the lesion site, suggesting PDGFRbeta was involved in glial scar formation. Then the PDGFR inhibitor (AG1296) was administered following TBI. Reactive astrocytes were significantly inhibited in AG1296-treated mice.
Increasing the adipogenic capacity of Pdgfrbeta(+) precursors through Pparg overexpression results in healthy visceral white adipose tissue expansion in obesity and adiponectin-dependent improvements in glucose homeostasis.
PDGFRalpha/PDGFRbeta signaling balance determines progenitor commitment to beige (Montrer LYST Anticorps) (PDGFRalpha) or white (PDGFRbeta) adipogenesis.
The data of this study revealed an acute accumulation of PDGFRbeta+ BBB (Montrer ALMS1 Anticorps)-related cells in degenerating brain areas, which can be long lasting, suggesting an active role for PDGFRbeta-signaling in blood vessel and post-injury tissue recovery.
Ltbp4 (Montrer LTBP4 Anticorps) regulates Pdgfrb expression via TGFbeta (Montrer TGFB1 Anticorps)-dependent modulation of Nrf2 (Montrer NFE2L2 Anticorps) transcription factor function.
The results provide functional evidence that elevated PDGFRbeta signaling causes tissue wasting or overgrowth reminiscent of human genetic syndromes and that the STAT1 (Montrer STAT1 Anticorps) pathway is a crucial modulator of this phenotypic spectrum.
Identify PDGFRbeta as a driver in activating Akt (Montrer AKT1 Anticorps)/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.
Data show that three platelet-derived growth factor receptor beta (PDGFRB) mutants (R561C, P660T and N666K) were able to transform NIH3T3 and Ba/F3 cells to different extents.
data therefore collectively suggest that upon TGFbeta (Montrer TGFB1 Anticorps) stimulation, SP1 (Montrer SP1 Anticorps) recruits SMAD2 (Montrer SMAD2 Anticorps) to the promoter of Pdgfrb to up-regulate its expression and thus Pdgfrb is a direct downstream target of the TGFbeta (Montrer TGFB1 Anticorps)/SMAD2 (Montrer SMAD2 Anticorps) signaling
PdgfrbetaF7/F7 mice between 4-6 and 36-48 weeks of age developed a region-dependent loss in pericyte coverage (22-46, 24-44 and 4-31%) and cell numbers (36-49, 34-64 and 11-36%), reduction in capillary length (20-39, 13-46 and 1-30%), and an increase in extravascular fibrinogen-derived deposits (3.4-5.2, 2.8-4.1 and 0-3.6-fold) demonstrating BBB (Montrer ALMS1 Anticorps) breakdown in the cortex, hippocampus and thalamus, respectively.
describes three unique PDGFRB fusions in childhood B- or T-ALL. All three PDGFRB fusion partners have previously been reported to be implicated in hematopoiesis and immune responses
These findings indicated that miR (Montrer MLXIP Anticorps)-518b may function as a tumor suppressor by targeting PDGFRB in the occurrence and development of GBM.
Data show that an equilibrium mixture of two unusual end-insertion G-quadruplexes forms in a native promoter sequence and appears to be the molecular recognition for platelet derived growth factor receptor beta (PDGFR-beta) downregulation.
Case Report: heterozygous PDGFRB mutation in a family presenting with multicentric autosomal dominant infantile myofibromatosis.
anlotinib inhibits the activation of VEGFR2 (Montrer KDR Anticorps), PDGFRbeta and FGFR1 (Montrer FGFR1 Anticorps) as well their common downstream ERK (Montrer EPHB2 Anticorps) signaling
PDGFRB is not a major causative gene of primary familial brain calcification in Chinese population.
overview of primary cilia-mediated regulation of receptor tyrosine kinase (Montrer RET Anticorps) (RTK- PDGFRa (Montrer PDGFRA Anticorps) and PDGFRb) and transforming growth factor beta (TGF-beta) signaling [review]
These findings indicate that the levels of phosphorylated PDGFR-beta are decreased in endothelial progenitor cells with the in vitro expansion process, which impairs their angiogenic potential by inhibiting PI3K (Montrer PIK3CA Anticorps)/Akt (Montrer AKT1 Anticorps) signaling.
This review showed that PDGFRB was one of the common gene involved included with brain calcification
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor\; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
CD140 antigen-like family member B
, PDGF beta chain
, beta platelet-derived growth factor receptor
, beta-type platelet-derived growth factor receptor
, platelet-derived growth factor receptor 1
, platelet-derived growth factor receptor beta
, platelet-derived growth factor receptor beta variant 1
, Platelet-derived growth factor receptor, beta
, protein tyrosin kinase