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anti-Human CNR1 Anticorps:
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Human Polyclonal CNR1 Primary Antibody pour ELISA, WB - ABIN250833
Porcella, Maxia, Gessa, Pani: The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein. dans The European journal of neuroscience 2000
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Dog (Canine) Polyclonal CNR1 Primary Antibody pour ELISA, WB - ABIN547528
Ledent, Valverde, Cossu, Petitet, Aubert, Beslot, Böhme, Imperato, Pedrazzini, Roques, Vassart, Fratta, Parmentier: Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. dans Science (New York, N.Y.) 1999
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Human Polyclonal CNR1 Primary Antibody pour ICC, IHC (fro) - ABIN152711
Mulhern, Madson, Danford, Ikesugi, Kador, Shinohara: The unfolded protein response in lens epithelial cells from galactosemic rat lenses. dans Investigative ophthalmology & visual science 2006
our findings further support that blocking peripheral CB1Rs would be beneficial to b-cell function in type 2 diabetes.
Tobacco-smoking healthy men have a widespread reduction of CB1 receptor density in brain. Reduction of CB1 receptors appears to be a common feature of substance use disorders.
subjects with mutant polymorphism (GA/AA) of CNR1, compared to the wild-type group (GG), had lower body mass index [Meta-Analysis; systematic review]
Genetic Susceptibility to Posttraumatic Stress Disorder: Analyses of the Oxytocin Receptor, Retinoic Acid Receptor-Related Orphan Receptor A and Cannabinoid Receptor 1 Genes
The association between two CNR1 gene polymorphisms and pain perception.
Our findings suggest that the expression levels of the clas-sical cannabinoid receptors, CB1 and CB2, are altered in both estrogen-dependent and the estrogen-independent endo-metrial cancers
Report alterations in the expression of cannabinoid receptors, apelin and S100A6 in the hearts of women over 50.
Happiness accompanied with being surrounded by happy people was the highest among Japanese individuals with the CC genotype, whereas among Canadian individuals, it was the highest in TT genotype carriers. These findings suggest that culture and CNR1 polymorphism interact to influence the perception of happiness.
These findings underline the modulatory role of the endocannabinoid system in stress effects on emotion and cognition and provide insights into the neural mechanisms that may contribute to the suggested protective effect of the AA/AG genotype of the CB1 receptor polymorphism against stress-related psychopathologies
miR-29a plays a pivotal role in the pathogenesis of diabetic glomerulosclerosis. We propose that overexpression of miR-29a may effectively repress CB1R-mediated inflammation, ECM accumulation, and reduction of PPAR-gamma signaling
Together, the data presented here indicate a close interaction between ageing and sex on the distribution and levels of cannabinoid receptors (CB1, CB2), S100A6 and CacyBP/SIP in the human heart.
Study showed that CB1 receptor gene expression was unchanged in the substantia nigra (SN) but significantly higher in the putamen (PUT) of patients with Parkinson's disease. CB2 receptor gene expression was significantly increased (4-fold) in the SN but decreased in the PUT, whereas monoacylglycerol Lipase gene expression was decreased in the SN and increased in the PUT.
cannabis consumption regulates the formation of CB1R-5HT2AR heteromers, and may have a key role in cognitive processing.
findings may open a new conceptual framework to understand the role of coordinated adenosine-endocannabinoid signaling in the indirect striatal pathway, which may be relevant in motor function and neurodegenerative diseases.
Study showed that relative to females, the cannabinoid CB1 receptor availability was on average 41% higher in males with a regionally specific effect larger in the posterior cingulate and retrosplenial cortices.
We focused on rs2180619 (A > G) polymorphism. We found, genotype-related differences in the impact of affective information in working memory(WM). carriers of at least one major allele focused on positive information in WM representations to a greater extent than negative and neutral information. carriers of two minor allele (GG) did not show a stronger preference for positive items, but a more general enhancement effect.
This study uncovers a PAX7-CB1 cross talk potentially exacerbating Duchenne muscular dystrophy.
The cannabinoid receptor 1 (CNR1) was identified as a direct target gene of miR1273g3pand knockdown of CNR1 restored the phenotypes of LoVo cells transfected with miR1273g3p inhibitor.
The Arg82 and Cys126 of CRIP1b are involved in the majority of hydrogen bond interactions with the CB1 receptor and are possible key residues required for interactions between the CB1 receptor and CRIP1b
The CB1 pathway is involved in the pathogenesis of shoulder stiffness. It may be a promising target for the treatment of rotator cuff lesions with shoulder stiffness.
Cnr1-/-Cnr2-/- mice are subfertile as a result of compromised implantation. Upon implantation, the epithelium is smooth and adhered to the blastocyst trophectoderm within the implantation chamber in wild-type mice, whereas the epithelium in Cnr1-/-Cnr2-/- mice is ruffled, which compromises appropriate blastocyst-uterine interactions. The suboptimal implantation leads to higher incidence of pregnancy failure in knockouts.
Study in rat and CD1R-/- mice show that spinal astrocytes co-express CB1-Rs and the 2-arachidonoylglycerol synthesizing enzyme, diacylglycerol lipase-alpha in close vicinity to each other. Evoked Ca2+ transients lead to the production of 2-arachidonoylglycerol in cultured astrocytes. The results provide evidence for a novel cannabinoid induced endocannabinoid release mechanism in astrocytes.
Results demonstrate that CB1 expressed in neural stem cells (NSCs) and their progeny controls neurogenesis in adult mice to regulate the NSC stem cell pool, dendritic morphology, activity-dependent plasticity, and behavior.
Studied role of cannabinoid receptor 1 (CB1R) in mitochondria of renal proximal tubular cells; found CB1R modulates mitochondrial physiology by regulating phosphorylation levels of dynamin-related protein 1.
Mutant mice lacking CB1 receptors from astroglial cells (GFAP-CB1-KO) displayed impaired object recognition memory and decreased in vivo and in vitro long-term potentiation (LTP) at CA3-CA1 hippocampal synapses. Activation of CB1 receptors increased intracellular astroglial Ca(2+) levels and extracellular levels of D-serine in hippocampal slices.
Delta(9)-tetrahydrocannabinol, the major psychoactive component of cannabis, produced dose-dependent conditioned place aversion and a reduction in intracranial self-stimulation behavior in VgluT2-cre control mice, but not in VgluT2-CB1 (-/-) mice. This suggests that activation of CB1Rs in VgluT2-expressing glutamate neurons produces aversive effects and might explain why cannabinoid is not rewarding in rodents.
Results suggest a crucial role for CB1 receptor in the progression of Alzheimer's disease-related pathological events.
This study shows, for the first time, that CB1R in RPTCs regulates GLUT2 expression and its dynamics and therefore, may affect the reabsorption of glucose during hyperglycemia.
Knockdown of CB1R in the CCK-D2 medium spiny neurons circuit elevated synaptic activity and promoted stress susceptibility.
constitutive genetic inactivation of sympathetic CB1 receptor disrupts the negative feedback loop between endocannabinoid and norepinephrine signaling in bone.
astrocytic TNFalpha levels were higher in GABA-Cnr1-/- mice, indicating that these morphological changes were accompanied by a more pro-inflammatory function. These findings demonstrate that the disruption of endocannabinoid signaling on GABAergic neurons is accompanied by functional changes in astrocyte activity, which are relevant to brain ageing
These findings suggest that CB1R expressed in KCs plays a critical role in obesity-related hepatic insulin resistance via a pro-inflammatory mechanism.
CB1R is a negative regulator of beta cell function and a mediator of islet inflammation under conditions of metabolic stress
Taste bud cells from CBR(-/-) mice also exhibited decreased Proglucagon and Glp-1r mRNA and a low GLP-1 basal level. We report that CBR is involved in fat taste perception via calcium signaling and GLP-1 secretion.
CNR1 deficiency attenuates insulin resistance and endoplasmic reticulum stress in heart of mice fed with high fat diet.
Results show that the subcellular CB1 receptor distribution in astrocytes in mice expressing CB1 receptors only in astrocytes completely matches the endogenous CB1 receptor expression and localization in astrocytes of the wild-type mouse hippocampus. Moreover, findings illustrate localization of CB1 receptors in astroglial mitochondria.
Results suggest that CB1R located on corticostriatal projections, by inhibiting glutamatergic transmission, protects dopamine D1 recpetor-medium spiny neurons not only from cortical mutant tHtt-evoked damage, as shown above, but also from astroglial mutant tHtt-evoked damage.
Results showed sensitivity of activated microglial cells to cannabinoids, increased CB1-CB2Het expression in activated microglia and in microglia from the hippocampus of an Alzheimer's model, and a correlation between levodopa-induced dyskinesia and striatal microglial activation in a Parkinson's disease model.
Cnr1 activation modulates both basal and challenged-induced locomotor activity.
genetic or chemical inhibition of cannabinoid receptor (Cnr) activity disrupts liver development and metabolic function in zebrafish.
The type 1 cannabinoid receptor lies upstream of CART and signals the appetite through the down-regulation of CART expression.
CB1 function is required in the early embryo for axonal growth and fasciculation.
The downregulation of cannabinoid receptor 1 and upregulation of monoglycerol lipase and fatty acid amide hydrolase in PVN was involved in the pathogenesis of type 2 diabetes.
This study provides unique evidence that the CB1R is dynamically and progressively involved from the start of mesial temporal lobe epileptogenesis
The result of this study provided a potential substrate for discrete, age-dependent effects of cannabinoid 1 receptor expression on the maturation of primate DLPFC circuitry.
The endocannabinoid system in renal cells: regulation of sodium transport by CB1 receptors through distinct cell signaling pathways
This study showed that FAAH gene expression was similar among high, medium and low fertile bulls and that CB1 expression was positively and significantly related to bull fertility.
Anandamide, through CB1 and TRPV1 activation, is involved in sperm release from the oviductal reservoir.
A novel mechanism has been identified underlying a CB1R-mediated increase in retinal ganglion cell intrinsic excitability acting through AMPK-dependent inhibition of NKCC1 activity.
CB1 functionality increased with development at both central and peripheral level.
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene.
cannabinoid receptor 1
, central cannabinoid receptor
, brain-type cannabinoid receptor
, striatal cannabinoid receptor type 1 protein
, CB1 cannabinoid receptor
, cannabinoid receptor CB-1
, cannabinoid receptor 1 (brain)
, cannabinoid receptor 1-like
, cannabinoid 1 receptor
, cannabinoid receptor 1/CB1